PHLDA2 Gene

HGNC Family	Pleckstrin homology domain containing (PLEKH)
Name	pleckstrin homology-like domain, family A, member 2
Description	This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPHLDA2 is a maternally expressed, imprinted gene that plays a pivotal role in placental development and fetal growth. Multiple studies have demonstrated that elevated placental PHLDA2 expression is associated with intrauterine growth restriction, lower birth weight, impaired skeletal growth, and even spontaneous pregnancy loss. Genetic variation within its promoter region can modulate expression levels and impact fetal growth trajectories, while environmental challenges such as hypoxia or conditions like preeclampsia further influence its expression. In trophoblast cells, increased PHLDA2 impairs proliferation, migration, and invasion, often triggering mitochondrial-dependent apoptosis and altering placental hormone production—factors that are thought to contribute to placental insufficiency and adverse perinatal outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in fetal development, aberrant PHLDA2 expression has been implicated in cancer progression. In several malignancies—including colorectal cancer, breast cancer, gastric cancer, glioma, and hepatocellular carcinoma—PHLDA2 is frequently upregulated. Functional studies indicate that elevated PHLDA2 levels enhance tumor cell proliferation, migration, invasion, and epithelial–mesenchymal transition while suppressing apoptotic and autophagic processes, with many of these effects mediated, at least in part, through the PI3K/AKT/mTOR pathway. These observations suggest that PHLDA2 may serve not only as an oncogenic driver but also as a potential prognostic marker in diverse tumor types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the mechanistic level, PHLDA2 expression is subject to regulation by epigenetic and post‐transcriptional mechanisms. For instance, disruptions in the RNAi machinery (such as Dicer knockdown) lead to chromatin changes and de‐repression of PHLDA2, while genetic polymorphisms and interactions with proteins like RhoGDI1 further modulate its stability and function. Such regulatory modifications not only influence placental growth and trophoblast behavior but may also impact tumor biology, making PHLDA2 a compelling target for both perinatal research and cancer therapeutics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wen-jie Shen, Fu-qi Xing, Ling-hong Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of imprinted genes related to Beckwith-Wiedemann syndrome in human oocytes and preimplantation embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15952111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15952111"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "H-S Kim, C-R Roh, B Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia regulates the expression of PHLDA2 in primary term human trophoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2006.01.025"}], "href": "https://doi.org/10.1016/j.placenta.2006.01.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16584773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16584773"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "S Apostolidou, S Abu-Amero, K O'Donoghue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated placental expression of the imprinted PHLDA2 gene is associated with low birth weight."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-006-0131-8"}], "href": "https://doi.org/10.1007/s00109-006-0131-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17180344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17180344"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sofia Dória, Mário Sousa, Susana Fernandes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression pattern of IGF2, PHLDA2, PEG10 and CDKN1C imprinted genes in spontaneous miscarriages or fetal deaths."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.5.5.12118"}], "href": "https://doi.org/10.4161/epi.5.5.12118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20484977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20484977"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "R M Lewis, J K Cleal, G Ntani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2011.11.003"}], "href": "https://doi.org/10.1016/j.bone.2011.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22100507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22100507"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Miho Ishida, David Monk, Andrew J Duncan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2012.02.021"}], "href": "https://doi.org/10.1016/j.ajhg.2012.02.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22444668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22444668"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "X Shi, Z He, Y Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental expression of PHLDA2 in selective intrauterine growth restriction in monozygotic twins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2014.03.006"}], "href": "https://doi.org/10.1016/j.placenta.2014.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24703004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24703004"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "A B Jensen, S J Tunster, R M John "}, {"type": "b", "children": [{"type": "t", "text": "The significance of elevated placental PHLDA2 in human growth restricted pregnancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2014.04.018"}], "href": "https://doi.org/10.1016/j.placenta.2014.04.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24953163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24953163"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Amilcar Cordeiro, Ana Paula Neto, Filipa Carvalho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relevance of genomic imprinting in intrauterine human growth expression of CDKN1C, H19, IGF2, KCNQ1 and PHLDA2 imprinted genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assist Reprod Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10815-014-0278-0"}], "href": "https://doi.org/10.1007/s10815-014-0278-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24986528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24986528"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Anna Bugge Janssen, Simon J Tunster, Alexander E P Heazell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12881-016-0279-1"}], "href": "https://doi.org/10.1186/s12881-016-0279-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26944942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26944942"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Feng Jin, Chong Qiao, Nannan Luan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of the imprinted gene pleckstrin homology-like domain family A member 2 in placental tissues of preeclampsia and its effects on the proliferation, migration and invasion of trophoblast cells JEG-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1440-1681.12468"}], "href": "https://doi.org/10.1111/1440-1681.12468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26218012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26218012"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yan Xing, Huiqiang Liu, Yunpu Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abundances of placental imprinted genes CDKN1C, PHLDA2 and IGF-2 are related to low birth weight and early catch-up growth in full-term infants born small for gestational age."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0218278"}], "href": "https://doi.org/10.1371/journal.pone.0218278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31194812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31194812"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Li Ding, Matthew J Blitz, Deborah A Wing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHLDA2 gene polymorphisms and risk of HELLP syndrome and severe preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pregnancy Hypertens (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.preghy.2020.01.013"}], "href": "https://doi.org/10.1016/j.preghy.2020.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32062476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32062476"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Guiyu Song, Feng Jin "}, {"type": "b", "children": [{"type": "t", "text": "RhoGDI1 interacts with PHLDA2, suppresses the proliferation, migration, and invasion of trophoblast cells, and participates in the pathogenesis of preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-022-00746-w"}], "href": "https://doi.org/10.1007/s13577-022-00746-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35841528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35841528"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhan Ma, Shuping Lou, Zheng Jiang "}, {"type": "b", "children": [{"type": "t", "text": "PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103117"}], "href": "https://doi.org/10.18632/aging.103117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32385195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32385195"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Flavia R Mangone, Maira Av Valoyes, Renan G do Nascimento, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/bmm-2020-0417"}], "href": "https://doi.org/10.2217/bmm-2020-0417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33179538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33179538"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Fei Xiao, Xinghong Liu, Yan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-Suppressing STF cDNA 3 Overexpression Suppresses Renal Fibrosis by Alleviating Anoikis Resistance and Inhibiting the PI3K/Akt Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Blood Press Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000517318"}], "href": "https://doi.org/10.1159/000517318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34284400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34284400"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Chengyong Guo, Shuo Liu, Tao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of PHLDA2 promotes apoptosis and autophagy of glioma cells through the AKT/mTOR pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurogenet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/01677063.2022.2096023"}], "href": "https://doi.org/10.1080/01677063.2022.2096023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35894264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35894264"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kun Feng, Hao Peng, Qingpeng Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHLDA2 reshapes the immune microenvironment and induces drug resistance in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.32604/or.2024.047078"}], "href": "https://doi.org/10.32604/or.2024.047078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38827322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38827322"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kai-Fu Tang, Yan Wang, Pengfei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of PHLDA2 in Dicer knockdown HEK293 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagen.2007.01.004"}], "href": "https://doi.org/10.1016/j.bbagen.2007.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17303335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17303335"}]}]}]}
Synonyms	HLDA2, TSSC3, BWR1C, BRW1C, IPL
Proteins	PHLA2_HUMAN
NCBI Gene ID	7262
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PHLDA2 has 12,172 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for PHLDA2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PHLDA2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHLDA2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHLDA2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PHLDA2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PHLDA2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHLDA2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PHLDA2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PHLDA2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PHLDA2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PHLDA2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PHLDA2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PHLDA2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PHLDA2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PHLDA2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PHLDA2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PHLDA2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PHLDA2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PHLDA2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PHLDA2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PHLDA2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PHLDA2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PHLDA2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PHLDA2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PHLDA2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PHLDA2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PHLDA2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PHLDA2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PHLDA2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PHLDA2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PHLDA2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PHLDA2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PHLDA2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PHLDA2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PHLDA2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PHLDA2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PHLDA2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PHLDA2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PHLDA2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PHLDA2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PHLDA2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PHLDA2 from the GeneSigDB Published Gene Signatures dataset.