PHOX2A Gene

HGNC Family	Homeoboxes
Name	paired-like homeobox 2a
Description	The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPHOX2A (also known as Arix) is a paired‐like homeodomain transcription factor that plays a central role in the development and maintenance of the autonomic nervous system. It has been shown to induce the transcription of key noradrenergic genes such as dopamine β‐hydroxylase (DBH) and, in association with other regulators, contributes to the specification of noradrenergic neurons. In addition, PHOX2A regulates the activity of additional targets—for example, modulating transcription of the gene encoding the α3 nicotinic acetylcholine receptor subunit—and its DNA–binding activity can be fine‐tuned by post‐translational modifications (e.g. phosphorylation by PKA or ERK1/2) that affect its functional interactions with target promoters. These molecular functions highlight its integral role in orchestrating the noradrenergic phenotype."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in noradrenergic differentiation, PHOX2A contributes to proper autonomic and neural crest cell development. It is expressed during early embryogenesis of autonomic ganglia and has been investigated as a candidate gene in conditions such as sudden infant death syndrome (SIDS) and neuroblastoma. Studies have linked altered PHOX2A expression or polymorphic regulatory variants to abnormalities in blood pressure regulation and neural crest‐derived tumors. Moreover, retinoic acid–mediated regulation of PHOX2A (in contrast to PHOX2B) further supports its value as a potential biomarker for tumor progression in neuroblastoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPHOX2A mutations or polymorphisms have also been implicated in congenital disorders affecting eye movements, such as congenital fibrosis of the extraocular muscles (CFEOM) and superior oblique muscle palsy. Several studies have identified novel variants in the PHOX2A (ARIX) gene that are associated with these strabismic anomalies, suggesting that its altered function may disrupt normal extraocular muscle development and differentiation. This expanding spectrum of PHOX2A–related phenotypes underscores its pleiotropic influence during both central nervous system and cranial nerve development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Megumi Adachi, Elaine J Lewis "}, {"type": "b", "children": [{"type": "t", "text": "The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201695200"}], "href": "https://doi.org/10.1074/jbc.M201695200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11943777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11943777"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marlene M Hsieh, George Lupas, Jennifer Rychlik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ERK1/2 is a negative regulator of homeodomain protein Arix/Phox2a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2005.03333.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2005.03333.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16156742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16156742"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jennifer L Rychlik, Marlene Hsieh, Lee E Eiden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1385/JMN:27:3:281"}], "href": "https://doi.org/10.1385/JMN:27:3:281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16280598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16280598"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Roberta Benfante, Adriano Flora, Simona Di Lascio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor PHOX2A regulates the human alpha3 nicotinic receptor subunit gene promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M608616200"}], "href": "https://doi.org/10.1074/jbc.M608616200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17344216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17344216"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Silvia Borghini, Marco Di Duca, Giuseppe Santamaria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.ejhg.5201852"}], "href": "https://doi.org/10.1038/sj.ejhg.5201852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17505528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17505528"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Debra E Weese-Mayer, Elizabeth M Berry-Kravis, Lili Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1203/01.PDR.0000136285.91048.4A"}], "href": "https://doi.org/10.1203/01.PDR.0000136285.91048.4A"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15240857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15240857"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tiziana Bachetti, Silvia Borghini, Roberto Ravazzolo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An in vitro approach to test the possible role of candidate factors in the transcriptional regulation of the RET proto-oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/000000005783992106"}], "href": "https://doi.org/10.3727/000000005783992106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16127999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16127999"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gen Wen, Jennifer Wessel, Weidong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddm123"}], "href": "https://doi.org/10.1093/hmg/ddm123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17584765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17584765"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "L Longo, S Borghini, F Schena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18949361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18949361"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Annica Wilzén, Staffan Nilsson, Rose-Marie Sjöberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Phox2 pathway is differentially expressed in neuroblastoma tumors, but no mutations were found in the candidate tumor suppressor gene PHOX2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo_00000196"}], "href": "https://doi.org/10.3892/ijo_00000196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19212675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19212675"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Simona Di Lascio, Elena Saba, Debora Belperio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2016.02.014"}], "href": "https://doi.org/10.1016/j.yexcr.2016.02.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26902400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26902400"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ahmad Yazdani, Daniel C Chung, Mohammad R Abbaszadegan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel PHOX2A/ARIX mutation in an Iranian family with congenital fibrosis of extraocular muscles type 2 (CFEOM2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Ophthalmol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0002-9394(03)00891-2"}], "href": "https://doi.org/10.1016/s0002-9394(03"}, {"type": "t", "text": "00891-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14597037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14597037"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yan Jiang, Toshihiko Matsuo, Hirotake Fujiwara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARIX and PHOX2B polymorphisms in patients with congenital superior oblique muscle palsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Med Okayama (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18926/AMO/31966"}], "href": "https://doi.org/10.18926/AMO/31966"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16049556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16049556"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sayuri Imai, Toshihiko Matsuo, Emi Itoshima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Med Okayama (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18926/AMO/30985"}], "href": "https://doi.org/10.18926/AMO/30985"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18323871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18323871"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sayuri Imai Ohkubo, Toshihiko Matsuo, Kayoko Hasebe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotype-phenotype and genotype-phenotype correlations in patients with idiopathic superior oblique muscle palsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2011.138"}], "href": "https://doi.org/10.1038/jhg.2011.138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22170461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22170461"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jia-mei Dong, Qin Shen, Jing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Identification of a novel PHOX2A gene mutation in a Chinese family with congenital fibrosis of extraocular muscles type 2]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2012.01.002"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2012.01.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22311481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22311481"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Gena Heidary, Sarah Mackinnon, Alexandra Elliott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J AAPOS (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaapos.2019.05.018"}], "href": "https://doi.org/10.1016/j.jaapos.2019.05.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31541710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31541710"}]}]}]}
Synonyms	CFEOM2, NCAM2, PMX2A, ARIX, FEOM2
Proteins	PHX2A_HUMAN
NCBI Gene ID	401
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PHOX2A has 4,530 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 111 datasets.

Click the + buttons to view associations for PHOX2A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PHOX2A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PHOX2A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHOX2A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHOX2A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PHOX2A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PHOX2A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PHOX2A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PHOX2A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PHOX2A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PHOX2A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PHOX2A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PHOX2A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PHOX2A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PHOX2A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PHOX2A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PHOX2A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PHOX2A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with PHOX2A gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PHOX2A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PHOX2A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PHOX2A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PHOX2A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PHOX2A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PHOX2A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PHOX2A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PHOX2A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PHOX2A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PHOX2A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PHOX2A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PHOX2A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving PHOX2A gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PHOX2A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PHOX2A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PHOX2A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PHOX2A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PHOX2A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PHOX2A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PHOX2A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PHOX2A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PHOX2A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PHOX2A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.