PIAS2 Gene

HGNC Family	Zinc fingers
Name	protein inhibitor of activated STAT, 2
Description	This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPIAS2, a member of the protein inhibitor of activated STAT family and a SUMO E3 ligase, plays a multifaceted role in the regulation of transcription factor activity and signaling pathways. By directly interacting with transcription factors such as STAT4, FLI‐1, and Elk‐1—as well as coregulators like UXT—PIAS2 modulates their transcriptional programs through SUMOylation. In several cellular contexts, it can function either as a co‐repressor or as a co‐activator without impairing DNA binding, thereby fine‐tuning pathway responses to diverse stimuli including cytokines and cellular stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of innate immunity and viral infection, PIAS2 enhances the SUMOylation of key viral RNA sensors such as MDA5, thereby potentiating type I interferon responses and restricting viral replication. Moreover, PIAS2 has been shown to control the stability and modification of viral proteins, as evidenced by its capacity to reduce the levels of hepatitis C virus core, NS3, and NS5A proteins via a SUMOylation-dependent proteasomal pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPIAS2 also contributes to tumor suppression and oncogenesis by regulating the SUMOylation status of critical tumor suppressors and oncogenic factors. For example, as a SUMO E3 ligase for PTEN, PIAS2 enhances PTEN protein stability by reducing its ubiquitination, thereby attenuating the PI3K-Akt survival pathway. In addition, PIAS2-mediated SUMO modification of transcription factors such as ZFHX3 has been linked to enhanced stability and oncogenic transcription in breast cancer models. Its expression levels are altered in thyroid cancer, with diminished levels noted in a significant subset of papillary thyroid carcinomas and specific isoforms (e.g., PIAS2β) acting as dosage-sensitive regulators in aggressive anaplastic thyroid cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in transcription regulation and viral defense, PIAS2 is implicated in the pathogenesis of several systemic and neurological disorders. Altered PIAS2 expression has been associated with inflammatory and autoimmune conditions such as multiple sclerosis and bipolar disorder, and specific genetic variants correlate with the severity of renal allograft fibrosis. Furthermore, dysregulated expression of PIAS2 is linked to neurodegenerative processes observed in sporadic Parkinson’s disease with dementia and to pathologies in migraine and diabetic nephropathy, underscoring its importance as a potential prognostic biomarker and therapeutic target across diverse diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Taruna Arora, Bin Liu, Hongchin He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C300119200"}], "href": "https://doi.org/10.1074/jbc.C300119200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12716907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12716907"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Emile van den Akker, Sabine Ano, Hsiu-Ming Shih, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M502938200"}], "href": "https://doi.org/10.1074/jbc.M502938200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16148010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16148010"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shen-Hsi Yang, Andrew D Sharrocks "}, {"type": "b", "children": [{"type": "t", "text": "PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.03.037"}], "href": "https://doi.org/10.1016/j.molcel.2006.03.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16713578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16713578"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiang Kong, Shikun Ma, Jiaqian Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2014.3023"}], "href": "https://doi.org/10.3892/mmr.2014.3023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25434787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25434787"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daipayan Chowdhury, Ajeet Singh, Avinash Gupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stress Chaperones (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12192-019-00974-4"}], "href": "https://doi.org/10.1007/s12192-019-00974-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30783905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30783905"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jihuan Fu, Yanbao Xiong, Youli Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2010.09.003"}], "href": "https://doi.org/10.1016/j.molimm.2010.09.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21156324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21156324"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jing Guo, Dan Chen, Xiaoxiao Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Viruses (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/v9100285"}], "href": "https://doi.org/10.3390/v9100285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28973998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28973998"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Weibin Wang, Yifan Chen, Shuya Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.508515"}], "href": "https://doi.org/10.1074/jbc.M113.508515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24344134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24344134"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "C Tuccilli, E Baldini, S Sorrenti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Regul Homeost Agents (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26403403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26403403"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rui Wu, Jiali Fang, Mingcheng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.012338"}], "href": "https://doi.org/10.1074/jbc.RA119.012338"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32249212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32249212"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Joana S Rodrigues, Miguel Chenlo, Susana B Bravo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-47751-1"}], "href": "https://doi.org/10.1038/s41467-024-47751-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38744818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38744818"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Arezou Sayad, Mohammad Taheri, Iman Azari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIAS genes as disease markers in bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28564"}], "href": "https://doi.org/10.1002/jcb.28564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30861611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30861611"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ebrahim Kouchaki, Hassan Nikoueinejad, Hossein Akbari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The investigation of relevancy between "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PIAS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PIAS2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene expression and disease severity of multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunoassay Immunochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15321819.2019.1613244"}], "href": "https://doi.org/10.1080/15321819.2019.1613244"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31084243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31084243"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zeping Gui, Wencheng Li, Shuang Fei, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41380-021-01207-w"}], "href": "https://doi.org/10.1038/s41380-021-01207-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34234281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34234281"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yuanqing Li, Hongchun Lin, Shuangshuang Shu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202200740RR"}], "href": "https://doi.org/10.1096/fj.202200740RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36251411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36251411"}]}]}]}
Synonyms	PIASX-ALPHA, SIZ2, ZMIZ4, PIASX, ARIP3, PIASX-BETA, MIZ1
Proteins	PIAS2_HUMAN
NCBI Gene ID	9063
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PIAS2 has 6,554 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for PIAS2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PIAS2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIAS2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIAS2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PIAS2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PIAS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PIAS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIAS2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving PIAS2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PIAS2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIAS2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIAS2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PIAS2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIAS2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PIAS2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PIAS2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PIAS2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIAS2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PIAS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PIAS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PIAS2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PIAS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PIAS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PIAS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PIAS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIAS2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PIAS2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PIAS2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PIAS2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PIAS2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PIAS2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PIAS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PIAS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PIAS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PIAS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PIAS2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIAS2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PIAS2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PIAS2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PIAS2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PIAS2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PIAS2 from the GeneSigDB Published Gene Signatures dataset.