PIBF1 Gene

Name	progesterone immunomodulatory binding factor 1
Description	This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPIBF1 is a progesterone‐regulated protein that plays a central role in pregnancy maintenance by modulating maternal immune responses. Early studies established that PIBF1 is produced by lymphocytes and trophoblast cells in response to progesterone, with alternative splicing generating distinct isoforms – a full‐length form that localizes to the nucleus and centrosomes, and shorter secreted forms that inhibit natural killer cell activity. PIBF1 shifts cytokine production toward a Th2 bias by upregulating anti‐inflammatory mediators and downregulating pro‐inflammatory signals, thereby creating a tolerogenic environment critical for a successful pregnancy. Moreover, circulating PIBF1 levels gradually increase with gestation, and lower levels are predictive of complications such as threatened abortion, preterm labor, and even graft rejection in non‐pregnant settings, highlighting its diagnostic potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its immunomodulatory role in pregnancy, PIBF1 is increasingly recognized for its function in cell proliferation, cycle regulation, and tumor progression. In several malignancies – including astrocytomas, glioblastomas, ovarian cancers, and triple‐negative breast cancer – PIBF1 is overexpressed and may contribute to enhanced cell growth, invasion, and immune evasion. Mechanistically, the full‐length PIBF1 localizes to the centrosomes where it participates in safeguarding spindle integrity during mitosis, while the alternatively spliced, smaller isoforms serve as paracrine modulators that can influence the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent findings have further expanded the functional portfolio of PIBF1 to include the regulation of placental development and embryogenesis. In the early placenta, PIBF1 is crucial for the differentiation and fusion of trophoblasts into syncytiotrophoblasts—a process essential not only for establishing the materno‐fetal barrier but also for mediating paracrine signals that promote vascular network formation and support embryonic cardiovascular development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Beata Polgar, Gyula Kispal, Margit Lachmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.171.11.5956"}], "href": "https://doi.org/10.4049/jimmunol.171.11.5956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14634107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14634107"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Beáta Polgár, Eszter Nagy, Eva Mikó, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urinary progesterone-induced blocking factor concentration is related to pregnancy outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.104.030437"}], "href": "https://doi.org/10.1095/biolreprod.104.030437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15269099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15269099"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Margit Lachmann, Dieter Gelbmann, Endre Kálmán, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.20326"}], "href": "https://doi.org/10.1002/ijc.20326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15305375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15305375"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Noemi Kozma, Melinda Halasz, Tamas Palkovics, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The progesterone-induced blocking factor modulates the balance of PKC and intracellular Ca."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Reprod Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0897.2005.00337.x"}], "href": "https://doi.org/10.1111/j.1600-0897.2005.00337.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16433831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16433831"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Igor Hudić, Zlatan Fatusić "}, {"type": "b", "children": [{"type": "t", "text": "Progesterone - induced blocking factor (PIBF) and Th(1)/Th(2) cytokine in women with threatened spontaneous abortion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Perinat Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/JPM.2009.061"}], "href": "https://doi.org/10.1515/JPM.2009.061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19290853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19290853"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Julia Szekeres-Bartho, Beata Polgar "}, {"type": "b", "children": [{"type": "t", "text": "PIBF: the double edged sword. Pregnancy and tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Reprod Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0897.2010.00833.x"}], "href": "https://doi.org/10.1111/j.1600-0897.2010.00833.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20367622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20367622"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "T Fekecs, K Kalmár-Nagy, P Szakály, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changes of progesterone-induced blocking factor in patients after kidney transplantation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transplant Proc (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.transproceed.2011.08.087"}], "href": "https://doi.org/10.1016/j.transproceed.2011.08.087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22172828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22172828"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shaohua Wu, Hong Zhang, Jiwen Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of kisspeptin/GPR54 and PIBF/PR in the first trimester trophoblast and decidua of women with recurrent spontaneous abortion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2013.09.017"}], "href": "https://doi.org/10.1016/j.prp.2013.09.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24225150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24225150"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Igor Hudić, Babill Stray-Pedersen, Julia Szekeres-Bartho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Reprod Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jri.2015.02.006"}], "href": "https://doi.org/10.1016/j.jri.2015.02.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25818991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25818991"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rachael A Cohen, Jerome H Check, Michael P Dougherty "}, {"type": "b", "children": [{"type": "t", "text": "Evidence that exposure to progesterone alone is a sufficient stimulus to cause a precipitous rise in the immunomodulatory protein the progesterone induced blocking factor (PIBF)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assist Reprod Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10815-015-0619-7"}], "href": "https://doi.org/10.1007/s10815-015-0619-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26634256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26634256"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Diptika Tiwari, Purabi Deka Bose, Rizwana Sultana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preterm delivery and associated negative pregnancy outcome - A tale of faulty progesterone receptor signalling pathway and linked derailed immunomodulation: A study from Northeast India."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Reprod Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jri.2016.10.001"}], "href": "https://doi.org/10.1016/j.jri.2016.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27728856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27728856"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Bihui Huang, Azure N Faucette, Michael D Pawlitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4244"}], "href": "https://doi.org/10.1038/nm.4244"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27918564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27918564"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mark Kit Lim, Chee Wai Ku, Thiam Chye Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-59452-y"}], "href": "https://doi.org/10.1038/s41598-020-59452-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32123187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32123187"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Mitra Rafiee, Abbas Rezaei, Razieh Alipour, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Progesterone-induced blocking factor (PIBF) influences the expression of membrane progesterone receptors (mPRs) on peripheral CD4"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " T lymphocyte cells in normal fertile females."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hormones (Athens) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s42000-021-00291-5"}], "href": "https://doi.org/10.1007/s42000-021-00291-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33914290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33914290"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Julia Szekeres-Bartho, Timea Csabai, Eva Gorgey "}, {"type": "b", "children": [{"type": "t", "text": "Biologia futura: embryo-maternal communication via progesterone-induced blocking factor (PIBF) positive embryo-derived extracellular vesicles. Their role in maternal immunomodulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Futur (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s42977-020-00060-2"}], "href": "https://doi.org/10.1007/s42977-020-00060-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34554496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34554496"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dobroslav Kyurkchiev, Emanuil Naydenov, Kalina Tumangelova-Yuzeir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cells isolated from human glioblastoma multiforme express progesterone-induced blocking factor (PIBF)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Neurobiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10571-014-0031-3"}], "href": "https://doi.org/10.1007/s10571-014-0031-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24474429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24474429"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Aliesha González-Arenas, Paulina Valadez-Cosmes, Carolina Jiménez-Arellano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Progesterone-induced blocking factor is hormonally regulated in human astrocytoma cells, and increases their growth through the IL-4R/JAK1/STAT6 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2014.09.007"}], "href": "https://doi.org/10.1016/j.jsbmb.2014.09.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25218441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25218441"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Tímea Balassa, Gergely Berta, László Jakab, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of the Progesterone-Induced Blocking Factor (PIBF) on E-cadherin expression, cell motility and invasion of primary tumour cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Reprod Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jri.2017.10.047"}], "href": "https://doi.org/10.1016/j.jri.2017.10.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29107859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29107859"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yusuf Madendag, Erdem Sahin, Ilknur Col Madendag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High Immune Expression of Progesterone-Induced Blocking Factor in Epithelial Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033818783911"}], "href": "https://doi.org/10.1177/1533033818783911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29962287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29962287"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Eun Ji Ro, Seung-Hee Ryu, Eun-Young Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIBF1 suppresses the ATR/CHK1 signaling pathway and promotes proliferation and motility of triple-negative breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-020-05732-0"}], "href": "https://doi.org/10.1007/s10549-020-05732-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32529408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32529408"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jong Geol Lee, Jung-Min Yon, Globinna Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-45647-8"}], "href": "https://doi.org/10.1038/s41467-024-45647-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38374152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38374152"}]}]}]}
Synonyms	PIBF, CEP90, C13ORF24, JBTS33
Proteins	PIBF1_HUMAN
NCBI Gene ID	10464
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PIBF1 has 6,595 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for PIBF1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PIBF1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIBF1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIBF1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PIBF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PIBF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PIBF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIBF1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PIBF1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIBF1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PIBF1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIBF1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PIBF1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PIBF1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PIBF1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIBF1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PIBF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PIBF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PIBF1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PIBF1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PIBF1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PIBF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PIBF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PIBF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PIBF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PIBF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIBF1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PIBF1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PIBF1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PIBF1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PIBF1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PIBF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PIBF1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PIBF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PIBF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PIBF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PIBF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PIBF1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIBF1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PIBF1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PIBF1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PIBF1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.