PIF1 Gene

Name	PIF1 5'-to-3' DNA helicase
Description	This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe evolutionarily conserved PIF1 family of DNA helicases plays a central role in maintaining genome integrity by targeting unusual nucleic acid structures. In particular, PIF1 enzymes efficiently bind and unwind G-quadruplex (G4) structures that can otherwise stall replication and trigger DNA damage, while simultaneously regulating telomere homeostasis through direct interactions with telomeric DNA and inhibition of telomerase activity. These activities protect chromosomes from deleterious genetic and epigenetic alterations and help preserve proper telomere length."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPIF1 also contributes critically to DNA replication and repair processes. It facilitates the unwinding of duplex DNA and the resolution of stalled replication forks—functions essential for break-induced replication (BIR) and DNA resection at complex sites, including those with embedded G4 motifs. Detailed kinetic and structural analyses reveal that PIF1 translocates along DNA in discrete steps powered by ATP hydrolysis and displays a unique channel for single-stranded DNA binding, ensuring timely replication restart and maintaining S-phase progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its catalytic functions, PIF1 is emerging as a critical player in cellular regulation and cancer biology. Alternative splicing generates isoforms that direct the protein to both the nucleus and mitochondria, aligning its activity with S-phase entry and genomic as well as mitochondrial DNA maintenance. Variants such as the cancer-associated L319P mutation compromise its helicase functions, thereby predisposing cells to genomic instability and tumorigenesis. Moreover, PIF1 is embedded in regulatory networks involving noncoding RNAs and post-translational modifications that modulate apoptotic responses, autophagy, and cell cycle progression in stressed or transformed cells, underscoring its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Deng-Hong Zhang, Bo Zhou, Yu Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkl029"}], "href": "https://doi.org/10.1093/nar/gkl029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16522649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16522649"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maria K Mateyak, Virginia A Zakian "}, {"type": "b", "children": [{"type": "t", "text": "Human PIF helicase is cell cycle regulated and associates with telomerase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.5.23.3524"}], "href": "https://doi.org/10.4161/cc.5.23.3524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17172855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17172855"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cyril M Sanders "}, {"type": "b", "children": [{"type": "t", "text": "Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20100612"}], "href": "https://doi.org/10.1042/BJ20100612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20524933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20524933"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Katrin Paeschke, Matthew L Bochman, P Daniela Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pif1 family helicases suppress genome instability at G-quadruplex motifs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature12149"}], "href": "https://doi.org/10.1038/nature12149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23657261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23657261"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alicia K Byrd, Kevin D Raney "}, {"type": "b", "children": [{"type": "t", "text": "A parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.630749"}], "href": "https://doi.org/10.1074/jbc.M114.630749"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25589786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25589786"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Thomas J Butler, Katrina N Estep, Joshua A Sommers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddaa043"}], "href": "https://doi.org/10.1093/hmg/ddaa043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32191790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32191790"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yongqing Gu, Yuji Masuda, Kenji Kamiya "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical analysis of human PIF1 helicase and functions of its N-terminal domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkn609"}], "href": "https://doi.org/10.1093/nar/gkn609"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18835853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18835853"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tresa George, Qin Wen, Richard Griffiths, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkp671"}], "href": "https://doi.org/10.1093/nar/gkp671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19700773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19700773"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mary E Gagou, Anil Ganesh, Ruth Thompson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of apoptosis by PIF1 helicase in human tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-4404"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-4404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21616935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21616935"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ramanagouda Ramanagoudr-Bhojappa, Shubeena Chib, Alicia K Byrd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.470013"}], "href": "https://doi.org/10.1074/jbc.M113.470013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23596008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23596008"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yongqing Gu, Jianxiao Wang, Shanshan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Determination of the biochemical properties of full-length human PIF1 ATPase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prion (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/pri.26022"}], "href": "https://doi.org/10.4161/pri.26022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23924759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23924759"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mary E Gagou, Anil Ganesh, Geraldine Phear, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2501"}], "href": "https://doi.org/10.18632/oncotarget.2501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25359767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25359767"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sonia Jimeno, Rosa Camarillo, Fernando Mejías-Navarro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.08.047"}], "href": "https://doi.org/10.1016/j.celrep.2018.08.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30232007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30232007"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Saba Dehghani-Tafti, Vladimir Levdikov, Alfred A Antson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz028"}], "href": "https://doi.org/10.1093/nar/gkz028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30698796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30698796"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kazunobu Futami, Akira Shimamoto, Yasuhiro Furuichi "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial and nuclear localization of human Pif1 helicase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Pharm Bull (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1248/bpb.30.1685"}], "href": "https://doi.org/10.1248/bpb.30.1685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17827721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17827721"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Karen M Chisholm, Sarah D Aubert, Krister P Freese, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0030748"}], "href": "https://doi.org/10.1371/journal.pone.0030748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22347400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22347400"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xianglian Zhou, Wendan Ren, Sakshibeedu R Bharath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and Functional Insights into the Unwinding Mechanism of Bacteroides sp Pif1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.02.008"}], "href": "https://doi.org/10.1016/j.celrep.2016.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26904952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26904952"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Bo Chen, Zhongyan Hua, Baocheng Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of PIF1, a potential new target of MYCN, induces apoptosis and inhibits cell migration in neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.117820"}], "href": "https://doi.org/10.1016/j.lfs.2020.117820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32512012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32512012"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Onyekachi E Ononye, Christopher W Sausen, Matthew L Bochman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic regulation of Pif1 acetylation is crucial to the maintenance of genome stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00294-020-01116-5"}], "href": "https://doi.org/10.1007/s00294-020-01116-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33079209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33079209"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Shibo Li, Hailong Wang, Sanaa Jehi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIF1 helicase promotes break-induced replication in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2020104509"}], "href": "https://doi.org/10.15252/embj.2020104509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33470420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33470420"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ting Zhang, Dong-Ming Wu, Peng-Wei Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-04561-x"}], "href": "https://doi.org/10.1038/s41419-022-04561-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35190532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35190532"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yujing Zhao, Juan Wu, Shuai Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Chron Obstruct Pulmon Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/COPD.S406453"}], "href": "https://doi.org/10.2147/COPD.S406453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37396201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37396201"}]}]}]}
Synonyms	PIF, C15ORF20
Proteins	PIF1_HUMAN
NCBI Gene ID	80119
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PIF1 has 6,333 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 106 datasets.

Click the + buttons to view associations for PIF1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PIF1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIF1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIF1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PIF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PIF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PIF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIF1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIF1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIF1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIF1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PIF1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PIF1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PIF1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIF1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PIF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PIF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PIF1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PIF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PIF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PIF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PIF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PIF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PIF1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PIF1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PIF1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PIF1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PIF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PIF1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PIF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PIF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PIF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PIF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PIF1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIF1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PIF1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PIF1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PIF1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PIF1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PIF1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of PIF1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of PIF1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.