PIK3C2B Gene

HGNC Family	C2 domain containing
Name	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Description	The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPIK3C2B, a class II phosphoinositide 3‐kinase, plays a multifaceted role in receptor‐mediated signaling in diverse cell types. In certain cancer models, such as small cell lung carcinoma, the enzyme is recruited by the stem cell factor receptor to contribute to protein kinase B (Akt) activation and cell growth, while in differentiating myeloid cells its activity increases in both the nucleus and nuclear envelope. Furthermore, PIK3C2B translocates to the nucleus in response to epidermal growth factor stimulation via a unique nuclear localization motif, revealing an important duality in its spatial regulation and suggesting distinct cytoplasmic and nuclear functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in signal propagation, PIK3C2B is a critical regulator of cytoskeletal dynamics and cellular motility. Overexpression of the enzyme has been shown to promote the formation of actin‐rich lamellipodia and filopodia, decrease integrin‐mediated adhesion, and consequently enhance cell migration. These features are integral not only to normal endothelial cell pinocytosis but also contribute to diverse aspects of tumor biology, as evidenced by its associations with esophageal cancer cell resistance to cisplatin, increased prostate cancer risk, and genomic alterations in oligodendroglial tumors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its contribution to cancer cell behavior, PIK3C2B has emerged as an important modulator in immune and neuronal contexts. In T lymphocytes, it operates upstream of nucleoside diphosphate kinase‐B to regulate the activity of the Ca²⁺‐activated K⁺ channel KCa3.1, a process further fine‐tuned by ubiquitination through TRIM27. Its aberrant expression in B cells has been linked to diminished vaccine responses in perinatally HIV‐infected children, while in neuroblastoma cells, PIK3C2B supports tumorigenesis through Akt activation downstream of intersectin 1. Notably, in contrast to these oncogenic roles, kinase domain mutations in non‐small cell lung carcinoma appear not to alter downstream signaling. Moreover, loss‐of‐function variants in PIK3C2B, which impair the production of rare phosphoinositide lipids, lead to mTORC1 hyperactivation and neuronal hyperexcitability underlying focal epilepsy. Additional post‐translational modifications such as nitrotyrosylation can enhance its activity in platelets, and although its expression in suprabasal epidermal cells suggested a potential role in differentiation, functional studies indicate that class II PI3K enzymes are non‐essential for this process. These diverse findings, including insights into cell cycle regulatory pathways, underscore the complex and context‐dependent functions of PIK3C2B in normal physiology and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexandre Arcaro, Umme K Khanzada, Bart Vanhaesebroeck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdf512"}], "href": "https://doi.org/10.1093/emboj/cdf512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12356726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12356726"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dora Visnjić, Vladiana Crljen, Josip Curić, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(02)03357-4"}], "href": "https://doi.org/10.1016/s0014-5793(02"}, {"type": "t", "text": "03357-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12372612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12372612"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Khin Thuzar Aung, Kazuaki Yoshioka, Sho Aki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12576-018-0644-2"}], "href": "https://doi.org/10.1007/s12576-018-0644-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30374841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30374841"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jan Domin, Lisa Harper, Deborah Aubyn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The class II phosphoinositide 3-kinase PI3K-C2beta regulates cell migration by a PtdIns3P dependent mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.20478"}], "href": "https://doi.org/10.1002/jcp.20478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16113997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16113997"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Roy M Katso, Olivier E Pardo, Andrea Palamidessi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e05-11-1083"}], "href": "https://doi.org/10.1091/mbc.e05-11-1083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16775008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16775008"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Stella Koutros, Fredrick R Schumacher, Richard B Hayes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3575"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20197460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20197460"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Z Liu, C Sun, Y Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol 3-kinase-C2β inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/147323001103900419"}], "href": "https://doi.org/10.1177/147323001103900419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21986133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21986133"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Matthieu Talagas, Pascale Marcorelles, Arnaud Uguen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel population in high-grade oligodendroglial tumors not deleted on 1p/19q using array CGH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-012-0909-1"}], "href": "https://doi.org/10.1007/s11060-012-0909-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22825724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22825724"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gianpaolo Tibolla, Roberto Piñeiro, Daniela Chiozzotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0053808"}], "href": "https://doi.org/10.1371/journal.pone.0053808"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23320105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23320105"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Thomas M Chiang, Arnold E Postlethwaite "}, {"type": "b", "children": [{"type": "t", "text": "Increase in phosphotidylinositide-3 kinase activity by nitrotyrosylation of lysates of platelets from patients with systemic sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagen.2005.09.001"}], "href": "https://doi.org/10.1016/j.bbagen.2005.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16271833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16271833"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kazutoshi Harada, Amy B Truong, Ti Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.24.11122-11130.2005"}], "href": "https://doi.org/10.1128/MCB.25.24.11122-11130.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314532"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shekhar Srivastava, Lie Di, Olga Zhdanova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-05-0390"}], "href": "https://doi.org/10.1091/mbc.e09-05-0390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19587117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19587117"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xinjiang Cai, Shekhar Srivastava, Yi Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1111233109"}], "href": "https://doi.org/10.1073/pnas.1111233109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22128329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22128329"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Angela Russo, Mustafa Nazir Okur, Maarten Bosland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2β) isoform contributes to neuroblastoma tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.01.026"}], "href": "https://doi.org/10.1016/j.canlet.2015.01.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25622909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25622909"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Marcus Kind, Jolanta Klukowska-Rötzler, Sabina Berezowska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Questioning the role of selected somatic PIK3C2B mutations in squamous non-small cell lung cancer oncogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0187308"}], "href": "https://doi.org/10.1371/journal.pone.0187308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29088297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29088297"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ouma Cisse, Muzthahid Quraishi, Federico Gulluni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1472-9"}], "href": "https://doi.org/10.1186/s13046-019-1472-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31752944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31752944"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Nicola Cotugno, Sonia Zicari, Elena Morrocchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Higher PIK3C2B gene expression of H1N1+ specific B-cells is associated with lower H1N1 immunogenicity after trivalent influenza vaccination in HIV infected children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clim.2020.108440"}], "href": "https://doi.org/10.1016/j.clim.2020.108440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32330555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32330555"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Philipp Alexander Koch, Gillian Leigh Dornan, Manuel Hessenberger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The molecular mechanisms mediating class II PI 3-kinase function in cell physiology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.15692"}], "href": "https://doi.org/10.1111/febs.15692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33387369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33387369"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Luca Gozzelino, Gaga Kochlamazashvili, Sara Baldassari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awac082"}], "href": "https://doi.org/10.1093/brain/awac082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35786744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35786744"}]}]}]}
Synonyms	C2-PI3K
Proteins	P3C2B_HUMAN
NCBI Gene ID	5287
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PIK3C2B has 7,610 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for PIK3C2B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PIK3C2B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIK3C2B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIK3C2B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PIK3C2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PIK3C2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIK3C2B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PIK3C2B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIK3C2B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIK3C2B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIK3C2B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PIK3C2B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PIK3C2B gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PIK3C2B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PIK3C2B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIK3C2B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PIK3C2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PIK3C2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PIK3C2B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PIK3C2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PIK3C2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PIK3C2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PIK3C2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PIK3C2B protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIK3C2B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PIK3C2B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PIK3C2B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PIK3C2B gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PIK3C2B gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PIK3C2B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PIK3C2B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PIK3C2B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PIK3C2B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PIK3C2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PIK3C2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PIK3C2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PIK3C2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PIK3C2B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIK3C2B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PIK3C2B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PIK3C2B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PIK3C2B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.