{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPINX1 is a multifunctional protein best known for its role as a critical telomerase inhibitor and regulator of telomere homeostasis. It exerts its telomerase‐inhibitory function by binding directly to components of the telomerase complex, such as the human telomerase reverse transcriptase (hTERT) and the RNA moiety (hTR), and by interacting with telomere‐binding proteins like TRF1. Domain‐mapping studies have revealed that its C-terminal region is responsible for the telomerase inhibitory activity, while distinct portions mediate binding to TRF1 and proper telomeric localization. In addition, PINX1 influences the recruitment of telomerase to telomeres and stabilizes telomeric protein complexes, thereby ensuring proper telomere length maintenance and genome integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its function in telomere regulation, PINX1 is involved in maintaining chromosomal stability during cell division. It localizes dynamically during the cell cycle—from the nucleolus and telomeres in interphase to the kinetochores and chromosome periphery during mitosis—where it contributes to proper spindle formation and accurate chromosome segregation. Moreover, studies using the yeast homolog Gno1p, which shares significant features with human PINX1, have implicated this protein in pre‐ribosomal RNA processing and ribosome biogenesis. Additionally, PINX1 undergoes post‐translational modifications (for example, phosphorylation by Polo-like kinase 1) that regulate its protein turnover and activity during mitosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various human cancers, deregulation of PINX1 expression has been linked to tumor progression and patient prognosis. Reduced or loss of PINX1 expression has been reported in ovarian, gastric, colorectal, cervical, non-small cell lung, and papillary thyroid carcinomas, where it usually correlates with high telomerase activity, enhanced metastatic potential, and poor clinical outcome. Conversely, in certain contexts such as nasopharyngeal carcinoma and gliomas, altered expression of PINX1 affects telomere dynamics and cell growth, while in prostate cancer, atypical upregulation and its action as an androgen receptor coactivator point to oncogenic properties. Furthermore, studies have demonstrated that PINX1 expression can be modulated by key regulatory factors including p53 and viral oncoproteins, as well as by genetic polymorphisms that may contribute to cancer susceptibility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional layers of PINX1 function include its roles in transcriptional regulation and interplay with other signaling pathways that impact cell proliferation and apoptosis. The promoter region of the PINX1 gene has been characterized as GC-rich with multiple potential transcription factor binding sites, indicating tight regulation at the transcriptional level. PINX1 also interacts with key regulators such as p53 and estrogen receptor α, functioning as a corepressor in some contexts while its stability is maintained by hTERT in the nucleolus. These diverse functions underscore PINX1’s status as an integrative hub that connects telomere maintenance with broader aspects of cell cycle control and gene expression, making it a promising candidate for both prognostic assessment and therapeutic targeting in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "27"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_fs", "start_ref": "28", "end_ref": "33"}, {"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marina Kriajevska, Margrethe Fischer-Larsen, Ejvind Moertz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110976200"}], "href": "https://doi.org/10.1074/jbc.M110976200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11836260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11836260"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Benjamin Guglielmi, Michel Werner "}, {"type": "b", "children": [{"type": "t", "text": "The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205526200"}], "href": "https://doi.org/10.1074/jbc.M205526200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12107183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12107183"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Soma S R Banik, Christopher M Counter "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408131200"}], "href": "https://doi.org/10.1074/jbc.M408131200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15381700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15381700"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bin Zhang, Yun Xiu Bai, Hang Hang Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-1393"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-1393"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19117989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19117989"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chong Wang, Jian Yu, Kai Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plk1-mediated mitotic phosphorylation of PinX1 regulates its stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2010.05.005"}], "href": "https://doi.org/10.1016/j.ejcb.2010.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20573420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20573420"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guoyuan Chen, Liang Da, Ying Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.06.136"}], "href": "https://doi.org/10.1016/j.bbrc.2010.06.136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20620128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20620128"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ponnarath Keo, Joong Sub Choi, Jaeman Bae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Stability of Nucleolar PinX1 in the Presence of TERT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2015.0144"}], "href": "https://doi.org/10.14348/molcells.2015.0144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26194824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26194824"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Na Li, Kai Yuan, Feng Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.04.077"}], "href": "https://doi.org/10.1016/j.bbrc.2009.04.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19393617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19393617"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kai Yuan, Na Li, Kai Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.001990"}], "href": "https://doi.org/10.1074/jbc.M109.001990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19553660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19553660"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jing Shen, Marilie D Gammon, Hui-Chen Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple genetic variants in telomere pathway genes and breast cancer risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-09-0771"}], "href": "https://doi.org/10.1158/1055-9965.EPI-09-0771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20056641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20056641"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yan-Ling Chen, Régine Capeyrou, Odile Humbert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gku357"}], "href": "https://doi.org/10.1093/nar/gku357"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24823796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24823796"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hong-bin Wang, Xing-wei Wang, Gang Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PinX1 inhibits telomerase activity in gastric cancer cells through Mad1/c-Myc pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastrointest Surg (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11605-010-1253-4"}], "href": "https://doi.org/10.1007/s11605-010-1253-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20544396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20544396"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mu-Yan Cai, Bin Zhang, Wei-Peng He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2010.01560.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2010.01560.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20367640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20367640"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Meilin Shi, Menghan Cao, Jun Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-015-0332-2"}], "href": "https://doi.org/10.1186/s12943-015-0332-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25888829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25888829"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Tomohiro Kondo, Naohide Oue, Yoshitsugu Mitani, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4163"}], "href": "https://doi.org/10.1002/path.4163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23341363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23341363"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hai-Long Li, Li Han, Hai-Rong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4011"}], "href": "https://doi.org/10.18632/oncotarget.4011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26033551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26033551"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiao-Peng Tian, Dong Qian, Li-Ru He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.07.012"}], "href": "https://doi.org/10.1016/j.canlet.2014.07.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25045845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25045845"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Xiao-Peng Tian, Xiao-Han Jin, Mei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The depletion of PinX1 involved in the tumorigenesis of non-small cell lung cancer promotes cell proliferation via p15/cyclin D1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-017-0637-4"}], "href": "https://doi.org/10.1186/s12943-017-0637-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28372542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28372542"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Gengze Wu, Dongbo Liu, Ke Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PinX1, a novel target gene of p53, is suppressed by HPV16 E6 in cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2014.01.004"}], "href": "https://doi.org/10.1016/j.bbagrm.2014.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24412852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24412852"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "JiHoon Kang, Kanghee Han, Hyeon Jin Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinical significance of PINX1 expression in papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2018.07.004"}], "href": "https://doi.org/10.1016/j.humpath.2018.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30026037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30026037"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yunyi Liu, Pinggui Gong, Ni Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insufficient PINX1 expression stimulates telomerase activation by direct inhibition of EBV LMP1-NF-κB axis during nasopharyngeal carcinoma development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.04.104"}], "href": "https://doi.org/10.1016/j.bbrc.2019.04.104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31027734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31027734"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Iván Flores-Ramírez, Miguel Ángel Rivas-Torres, Mauricio Rodríguez-Dorantes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2021.105858"}], "href": "https://doi.org/10.1016/j.jsbmb.2021.105858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33647521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33647521"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Methee Sriprapun, Natthaya Chuaypen, Apichaya Khlaiphuengsin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of PINX1 but not TEP1 Polymorphisms with Progression to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2016.17.4.2019"}], "href": "https://doi.org/10.7314/apjcp.2016.17.4.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27221889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27221889"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Cheng Liao, Mu-Jun Zhao, Jing Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expression of LPTS-L in hepatocellular carcinoma cell line SMMC-7721 induces crisis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v8.i6.1050"}], "href": "https://doi.org/10.3748/wjg.v8.i6.1050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12439923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12439923"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Cheng Liao, Mu-Jun Zhao, Jing Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v9.i1.89"}], "href": "https://doi.org/10.3748/wjg.v9.i1.89"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12508358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12508358"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Suiquan Wang, Cheng Liao, Tsaiping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and characterization of the promoter region of human LPTS/PinX1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbaexp.2003.12.002"}], "href": "https://doi.org/10.1016/j.bbaexp.2003.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14984932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14984932"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Maria Yamilet Noriega-Reyes, Miguel Angel Rivas-Torres, Luis Fernando Oñate-Ocaña, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role for PINX1 as a coregulator of nuclear hormone receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2015.07.011"}], "href": "https://doi.org/10.1016/j.mce.2015.07.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26187699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26187699"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jeong Eun Yoo, Young Nyun Park, Bong-Kyeong Oh "}, {"type": "b", "children": [{"type": "t", "text": "PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.506006"}], "href": "https://doi.org/10.1074/jbc.M113.506006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24415760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24415760"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Wenying Deng, Nanlin Jiao, Ning Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Efficient expression of recombinant human telomerase inhibitor 1 (hPinX1) in Pichia pastoris."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prep Biochem Biotechnol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10826068.2018.1466160"}], "href": "https://doi.org/10.1080/10826068.2018.1466160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29958061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29958061"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Congxiang Shen, Fang Chen, Huigang Wang, et al. 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