| Name | prolactin-induced protein |
| Description | Enables IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of T cell apoptotic process; and proteolysis. Located in extracellular space and nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nProlactin‐induced protein (PIP), also known as gross cystic disease fluid protein‐15, is a secreted glycoprotein with multifaceted biochemical activities. Early studies revealed that PIP functions as an aspartyl protease capable of specifically cleaving fibronectin, and its structure shows similarities to retroviral aspartyl proteinases. In addition, PIP directly interacts with cell surface molecules such as CD4, thereby modulating T‐cell apoptosis, which may contribute to immune regulation in both normal and tumor microenvironments."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer cells, PIP expression is tightly regulated by hormonal cues – notably by androgens and prolactin through transcription factors such as Runx2 – and plays a critical role in promoting cell proliferation, invasion, and adhesion. Functional studies in T47D and other cell models have demonstrated that PIP supports cell cycle progression and invasion by modulating receptor tyrosine kinase signaling (affecting such kinases as FAK, AKT, ERK, and JNK), facilitating microtubule polymerization by interacting with β‑tubulin, and enabling efficient integrin-mediated adhesion via actin and its associated proteins. Furthermore, reduced levels of PIP in invasive breast tissue and its association with altered gene expression networks have been linked to disease aggressiveness, while its high expression also sensitizes cancer cells to chemotherapeutic agents by upregulating pro‑apoptotic genes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in tumor biology, PIP is implicated in several physiological processes. Structural investigations have uncovered its ability to form stable complexes with proteins such as zinc‐α2‐glycoprotein and human serum albumin, linking it to functions in fertility and reproductive physiology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " Recent work has also illustrated a role for PIP in non‐breast tissues: in salivary glands, it interacts with aquaporin‑5 to regulate water channel trafficking and, in pulmonary tissue, PIP produced by macrophages under transcriptional control of Slug promotes vascular smooth muscle cell proliferation, contributing to pulmonary hypertension in the setting of fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In the context of dermatologic and immunologic disorders, PIP has emerged as a sensitive biomarker in keratoconus and influences cell adhesion by regulating podosome formation, while studies using invariant natural killer T cells demonstrated that secreted PIP can trigger dendritic cell maturation through TLR2‐mediated pathways, thereby shaping adaptive immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "E Caputo, G Manco, L Mandrich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel aspartyl proteinase from apocrine epithelia and breast tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2000)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.275.11.7935"}], "href": "https://doi.org/10.1074/jbc.275.11.7935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10713110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10713110"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Emilia Caputo, Alessandra Camarca, Ramy Moharram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural study of GCDFP-15/gp17 in disease versus physiological conditions using a proteomic approach."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi034038a"}], "href": "https://doi.org/10.1021/bi034038a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12755619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12755619"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Toshima Z Parris, Anikó Kovács, Luaay Aziz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.28497"}], "href": "https://doi.org/10.1002/ijc.28497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24114735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24114735"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sanjeev K Baniwal, Gillian H Little, Nyam-Osor Chimge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.22966"}], "href": "https://doi.org/10.1002/jcp.22966"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21809344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21809344"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sanjeev K Baniwal, Nyam-Osor Chimge, V Craig Jordan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0062361"}], "href": "https://doi.org/10.1371/journal.pone.0062361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23755096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23755096"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ali Naderi, Marion Vanneste "}, {"type": "b", "children": [{"type": "t", "text": "Prolactin-induced protein is required for cell cycle progression in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2014.04.001"}], "href": "https://doi.org/10.1016/j.neo.2014.04.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24862759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24862759"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anna Urbaniak, Karolina Jablonska, Jaroslaw Suchanski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolactin-induced protein (PIP) increases the sensitivity of breast cancer cells to drug-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-33707-w"}], "href": "https://doi.org/10.1038/s41598-023-33707-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37085653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37085653"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Md Imtaiyaz Hassan, Sameeta Bilgrami, Vijay Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2008.09.072"}], "href": "https://doi.org/10.1016/j.jmb.2008.09.072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18930737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18930737"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sanjay Kumar, Anil Kumar Tomar, Sudhuman Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human serum albumin as a new interacting partner of prolactin inducible protein in human seminal plasma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2011.12.015"}], "href": "https://doi.org/10.1016/j.ijbiomac.2011.12.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22209935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22209935"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Anil Kumar Tomar, Balwinder Singh Sooch, Isha Raj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction analysis identifies semenogelin I fragments as new binding partners of PIP in human seminal plasma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Macromol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijbiomac.2012.10.011"}], "href": "https://doi.org/10.1016/j.ijbiomac.2012.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23085372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23085372"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Clara Chivasso, Veronika Nesverova, Michael Järvå, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10082108"}], "href": "https://doi.org/10.3390/cells10082108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34440877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34440877"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Gregoire Ruffenach, Soban Umar, Mylene Vaillancourt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histological hallmarks and role of Slug/PIP axis in pulmonary hypertension secondary to pulmonary fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201810061"}], "href": "https://doi.org/10.15252/emmm.201810061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31468711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31468711"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shrestha Priyadarsini, Jesper Hjortdal, Akhee Sarker-Nag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gross cystic disease fluid protein-15/prolactin-inducible protein as a biomarker for keratoconus disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0113310"}], "href": "https://doi.org/10.1371/journal.pone.0113310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25405607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25405607"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Marion Vanneste, Ali Naderi "}, {"type": "b", "children": [{"type": "t", "text": "Prolactin-Induced Protein regulates cell adhesion in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.11.043"}], "href": "https://doi.org/10.1016/j.bbrc.2015.11.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26585492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26585492"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Alena Wiegandt, Henning N Behnken, Bernd Meyer "}, {"type": "b", "children": [{"type": "t", "text": "Unusual N-type glycosylation of salivary prolactin-inducible protein (PIP): multiple Lewis"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "Y"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " epitopes generate highly-fucosylated glycan structures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycoconj J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10719-018-9826-7"}], "href": "https://doi.org/10.1007/s10719-018-9826-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29858715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29858715"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Koji Kamiya, Jun-Ichi Sakabe, Hayato Yamaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gross cystic disease fluid protein 15 in stratum corneum is a potential marker of decreased eccrine sweating for atopic dermatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0125082"}], "href": "https://doi.org/10.1371/journal.pone.0125082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25919462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25919462"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hyeong-Woo Lee, Juhyun Shin, Brian S Wilson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1875664"}], "href": "https://doi.org/10.1080/21655979.2021.1875664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33509033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33509033"}]}]}]}
|
| Synonyms | GPIP4, GCDFP15, GCDFP-15 |
| Proteins | PIP_HUMAN |
| NCBI Gene ID | 5304 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
PIP has 7,452 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 87 datasets.
Click the + buttons to view associations for PIP from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PIP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PIP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PIP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of PIP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PIP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PIP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PIP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PIP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with PIP gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIP gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of PIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of PIP gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PIP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PIP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with PIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PIP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with PIP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with PIP gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with PIP gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of PIP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by PIP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DGIdb Drug Targets 2026 | interacting drugs for PIP protein from the DGIdb Drug Targets 2026 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with PIP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with PIP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with PIP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PIP gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIP gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of PIP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with PIP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with PIP gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of PIP gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with PIP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PIP from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of PIP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PIP gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PIP gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PIP gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PIP gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PIP gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding PIP protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving PIP gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving PIP gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing PIP protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing PIP protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by PIP gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by PIP gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PIP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PIP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PIP gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of PIP gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of PIP gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of PIP protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of PIP protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for PIP from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with PIP gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with PIP gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with PIP gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PIP gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for PIP protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PIP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PIP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with PIP gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PIP gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of PIP gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of PIP gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PIP gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PIP protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by PIP gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PIP gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by PIP gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of PIP gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NURSA Protein Complexes | protein complexs containing PIP protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for PIP from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PIP gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving PIP protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| Reactome Pathways 2024 | pathways involving PIP protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PIP gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of PIP gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with PIP protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PIP gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PIP gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of PIP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of PIP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PIP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
