PIP4K2A Gene

Name	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Description	Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPIP4K2A functions as a key regulator of phosphoinositide metabolism by catalyzing the conversion of phosphatidylinositol‑5‑phosphate (PtdIns5P) to phosphatidylinositol‑4,5‑bisphosphate [PI(4,5)P2]. This activity modulates diverse signaling cascades that govern cellular energy homeostasis, membrane trafficking, and insulin‐dependent signaling. For example, loss of PIP4K enzymes causes a paradoxical increase in PI(4,5)P2 by unleashing PIP5K activity, leading to enhanced PI3K pathway activation in insulin‑stimulated cells, while knockdown of PIP4K2A reduces peroxisomal PI(4,5)P2 levels and disturbs cholesterol transport from lysosomes to peroxisomes. Such studies highlight an allosteric role for PIP4K2A in setting the threshold for phosphoinositide synthesis and integrating metabolic signaling responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various cancers and hematologic malignancies, PIP4K2A has emerged as a critical modulator of cell proliferation and survival. In p53‐deficient breast cancers, downregulation of PIP4K2 isoforms results in oxidative stress and senescence, whereas in glioblastoma PIP4K2A overexpression curbs PI3K signaling via targeted degradation of PI3K subunits, thereby suppressing tumor growth. In acute myeloid leukemia, PIP4K2A is essential for maintaining clonogenic and leukemia‑initiating potential, and its knockdown leads to cell cycle arrest with accumulation of cyclin‑dependent kinase inhibitors. Genetic association studies in childhood and hyperdiploid acute lymphoblastic leukemia further implicate risk variants in PIP4K2A. Moreover, proteomic investigations have identified PIP4K2A as an off‑target of anticancer agents such as volasertib, underscoring its biological relevance in tumor cell survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the nervous system, genetic and expression studies have implicated PIP4K2A in the modulation of neuronal activity and psychiatric disease susceptibility. Variants in this gene are associated with schizophrenia and bipolar disorder, and experimental evidence suggests that PIP4K2A can regulate neurotransmission by modulating the levels of phosphoinositide messengers that affect the function of ion channels and neurotransmitter transporters such as EAAT3 and KCNQ channels. In addition, detailed immunolocalization studies reveal that PI5P4Kα (the protein product of PIP4K2A) is distributed in specific brain regions, including areas involved in higher cognitive processing, thus supporting a role for phosphoinositide signaling dysregulation in neuropsychiatric pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "18"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in signaling and oncogenesis, PIP4K2A is implicated in immune recognition and even in host–pathogen interactions. Processing of PIP4K2A can generate immunogenic peptides that function as minor histocompatibility antigens, which may influence graft‐versus‐leukemia effects in the transplantation setting. In addition, emerging data indicate that PIP4K2A can bind specific RNA elements, as observed in Plasmodium falciparum where host PIP4K2A is imported and associates with RNA regulatory regions, hinting at a non‑canonical role in mRNA translation. Finally, association studies have linked PIP4K2A polymorphisms with other complex conditions such as alcohol use disorder and susceptibility to childhood acute lymphoblastic leukemia, suggesting that its functional spectrum extends to the regulation of transcriptional programs in diverse cell types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "23"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ao Hu, Xue-Tong Zhao, Heng Tu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2013.09.057"}], "href": "https://doi.org/10.1016/j.cell.2013.09.057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24209622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24209622"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Julian G Jude, Gary J Spencer, Xu Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.77"}], "href": "https://doi.org/10.1038/onc.2014.77"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24681948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24681948"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yong Jae Shin, Jason K Sa, Yeri Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIP4K2A as a negative regulator of PI3K in PTEN"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "-"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "deficient glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20172170"}], "href": "https://doi.org/10.1084/jem.20172170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30898893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30898893"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dan Nie, Xin Tang, Haijun Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre-mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202305374"}], "href": "https://doi.org/10.1002/advs.202305374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38059827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38059827"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gabriele Migliorini, Bettina Fiege, Fay J Hosking, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-03-491316"}], "href": "https://doi.org/10.1182/blood-2013-03-491316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23996088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23996088"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Vânia Peretti de Albuquerque Wobeto, João Agostinho Machado-Neto, Tânia Regina Zaccariotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIPKIIα is widely expressed in hematopoietic-derived cells and may play a role in the expression of alpha- and gamma-globins in K562 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-014-2054-y"}], "href": "https://doi.org/10.1007/s11010-014-2054-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24788727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24788727"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Oksana Goroshchuk, Iryna Kolosenko, Elena Kunold, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202100457RR"}], "href": "https://doi.org/10.1096/fj.202100457RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34143546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34143546"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "S C Bakker, M L C Hoogendoorn, J Hendriks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Brain Behav (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1601-183x.2006.00234.x"}], "href": "https://doi.org/10.1111/j.1601-183x.2006.00234.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17410640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17410640"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "S G Schwab, M Knapp, P Sklar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIalpha gene (PIP5K2A) with schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.mp.4001864"}], "href": "https://doi.org/10.1038/sj.mp.4001864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16801950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16801950"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "János M Réthelyi, Steven C Bakker, Patrícia Polgár, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.31049"}], "href": "https://doi.org/10.1002/ajmg.b.31049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19937977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19937977"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Olga Fedorenko, Cai Tang, Mentor Sopjani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychopharmacology (Berl) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00213-009-1621-5"}], "href": "https://doi.org/10.1007/s00213-009-1621-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19644675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19644675"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Harpreet Kaur, Ajay Jajodia, Sandeep Grover, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Contributions of ARID5B, IKZF1, PIP4K2A, and GATA3 Gene Polymorphisms to Childhood Acute Lymphoblastic Leukemia in a Chinese Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Hematol Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MPH.0000000000002646"}], "href": "https://doi.org/10.1097/MPH.0000000000002646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36952466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36952466"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Olga Yu Fedorenko, Ekaterina V Mikhalitskaya, Valentina A Toshchakova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PIP4K2A"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Polymorphisms with Alcohol Use Disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes12101642"}], "href": "https://doi.org/10.3390/genes12101642"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34681036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34681036"}]}]}]}
Synonyms	PIP5K2A, PIP5KIIA, PIP5KII-ALPHA, PI5P4KA, PIPK
Proteins	PI42A_HUMAN
NCBI Gene ID	5305
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PIP4K2A has 8,818 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 137 datasets.

Click the + buttons to view associations for PIP4K2A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PIP4K2A Gene

Functional Associations

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	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIP4K2A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIP4K2A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PIP4K2A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PIP4K2A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PIP4K2A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PIP4K2A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PIP4K2A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIP4K2A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PIP4K2A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PIP4K2A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIP4K2A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PIP4K2A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PIP4K2A gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PIP4K2A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PIP4K2A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PIP4K2A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PIP4K2A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PIP4K2A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PIP4K2A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PIP4K2A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PIP4K2A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PIP4K2A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PIP4K2A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PIP4K2A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PIP4K2A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PIP4K2A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PIP4K2A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PIP4K2A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PIP4K2A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PIP4K2A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PIP4K2A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PIP4K2A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for PIP4K2A protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PIP4K2A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PIP4K2A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PIP4K2A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PIP4K2A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PIP4K2A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PIP4K2A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PIP4K2A gene from the ENCODE Histone Modification Site Profiles dataset.