{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPLAC1 is a placenta‐specific gene that is normally expressed exclusively in trophoblast cells of the placenta, where it localizes predominantly to the differentiated syncytiotrophoblast and its apical membrane. Multiple studies have shown that PLAC1 plays a pivotal role in placental development by regulating trophoblast differentiation, fusion (syncytialization), migration, and invasion—processes that are essential for establishing and maintaining the maternal–fetal interface. Its expression is modulated by growth factors such as keratinocyte growth factor and appears sensitive to the physiological status of pregnancy, with altered PLAC1 mRNA levels in maternal blood being associated with pregnancy complications like preeclampsia and fetal growth restriction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to its tightly regulated, tissue‐restricted expression in normal placental development, PLAC1 is aberrantly activated in a wide range of human cancers—including breast, ovarian, lung, colorectal, hepatocellular, gastric, and nasopharyngeal carcinomas—where it functions as an oncoprotein. In tumor cells, PLAC1 promotes malignant behaviors by enhancing cell proliferation, motility, invasion, and metastasis. Mechanistically, its activity has been linked to the regulation of cell cycle mediators (such as cyclin D1), activation of the AKT signaling cascade, and interactions with proteins like Furin that modulate Notch and PTEN pathways. Furthermore, transcription factors such as SP1, C/EBPβ, and estrogen receptor α contribute to its cancer‐specific expression through nonclassical signaling, while its cell surface localization renders PLAC1 a promising target for immunotherapeutic interventions. Indeed, peptide epitopes derived from PLAC1 have been shown to trigger both cytotoxic and helper T‐cell responses, and elevated PLAC1 levels in tumors correlate with poorer clinical outcomes—underscoring its potential as both a prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "42"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael Fant, David L Weisoly, Massimo Cocchia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.10200"}], "href": "https://doi.org/10.1002/mrd.10200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12412044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12412044"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Manuela Concu, Irina Banzola, Antonio Farina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fetal Diagn Ther (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000081365"}], "href": "https://doi.org/10.1159/000081365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15608456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15608456"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eltayab Massabbal, Shanaz Parveen, D L Weisoly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.20272"}], "href": "https://doi.org/10.1002/mrd.20272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15803460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15803460"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Naoya Fujito, Osamu Samura, Norio Miharu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hiroshima J Med Sci (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16594548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16594548"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nicola Rizzo, Irina Banzola, Manuela Concu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1 mRNA levels in maternal blood at induction of labor correlate negatively with induction-delivery interval."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Obstet Gynecol Reprod Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejogrb.2006.05.039"}], "href": "https://doi.org/10.1016/j.ejogrb.2006.05.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16860456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16860456"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Michael Fant, Hugo Barerra-Saldana, William Dubinsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.20673"}], "href": "https://doi.org/10.1002/mrd.20673"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17186554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17186554"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yuditiya Purwosunu, Akihiko Sekizawa, Antonio Farina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell-free mRNA concentrations of CRH, PLAC1, and selectin-P are increased in the plasma of pregnant women with preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prenat Diagn (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pd.1780"}], "href": "https://doi.org/10.1002/pd.1780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17554801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17554801"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dandan Sun, Hanbing Wu, Zepeng Ping, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1 Regulates the Occurrence of Fetal Growth Restriction by Inhibiting the Apoptosis of Trophoblast Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Lab Sci (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33941557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33941557"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yaohui Chen, Carole Stagg, David Schlessinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1 affects cell to cell communication by interacting with the desmosome complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2021.06.001"}], "href": "https://doi.org/10.1016/j.placenta.2021.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34118612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34118612"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Massimo Conese, Ottavio Napolitano, Onofrio Laselva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Oncogenic Theory of Preeclampsia: Is Amniotic Mesenchymal Stem Cells-Derived PLAC1 Involved?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24043612"}], "href": "https://doi.org/10.3390/ijms24043612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36835024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36835024"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Michael Koslowski, Ugur Sahin, Rita Mitnacht-Kraus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-1350"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-1350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17909063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17909063"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wilson A Silva, Sacha Gnjatic, Erika Ritter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1, a trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Immun (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17983203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17983203"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xue-Yuan Dong, Ji-Run Peng, Ying-Jiang Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.23341"}], "href": "https://doi.org/10.1002/ijc.23341"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18183594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18183594"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nana E Tchabo, Paulette Mhawech-Fauceglia, Otavia L Caballero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and serum immunoreactivity of developmentally restricted differentiation antigens in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Immun (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19705800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19705800"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Michael Fant, Antonio Farina, Ramaiah Nagaraja, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1 (Placenta-specific 1): a novel, X-linked gene with roles in reproductive and cancer biology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prenat Diagn (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pd.2506"}], "href": "https://doi.org/10.1002/pd.2506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20509147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20509147"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Fang-Fang Liu, Dan-Hua Shen, Shan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of PLAC1/CP1 genes in primary colorectal carcinoma and its clinical significance]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Bing Li Xue Za Zhi (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21215095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21215095"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wei Liu, Mingxia Zhai, Zongyin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-011-0966-3"}], "href": "https://doi.org/10.1007/s00726-011-0966-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21710262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21710262"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Y Chen, A Moradin, D Schlessinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RXRα and LXR activate two promoters in placenta- and tumor-specific expression of PLAC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2011.08.011"}], "href": "https://doi.org/10.1016/j.placenta.2011.08.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21937108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21937108"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "M Matteo, P Greco, P E Levi Setti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary evidence for high anti-PLAC1 antibody levels in infertile patients with repeated unexplained implantation failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2013.01.006"}], "href": "https://doi.org/10.1016/j.placenta.2013.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23434395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23434395"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Fangfang Liu, Henghui Zhang, Danhua Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of two new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from colorectal carcinoma-associated antigen PLAC1/CP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00535-013-0811-4"}], "href": "https://doi.org/10.1007/s00535-013-0811-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23604623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23604623"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Meike Wagner, Michael Koslowski, Claudia Paret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-570"}], "href": "https://doi.org/10.1186/1471-2407-13-570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24304549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24304549"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xia Wang, Melody C Baddoo, Qinyan Yin "}, {"type": "b", "children": [{"type": "t", "text": "The placental specific gene, PLAC1, is induced by the Epstein-Barr virus and is expressed in human tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virol J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1743-422X-11-107"}], "href": "https://doi.org/10.1186/1743-422X-11-107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24912876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24912876"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Wen-Lin Chang, Qing Yang, Hui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of placenta-specific protein 1 in trophoblast invasion and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reproduction (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/REP-14-0052"}], "href": "https://doi.org/10.1530/REP-14-0052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24989904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24989904"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Margherita Zanello, Akihiko Sekizawa, Yuditiya Purwosunu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating mRNA for the PLAC1 gene as a second trimester marker (14-18 weeks' gestation) in the screening for late preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fetal Diagn Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000360854"}], "href": "https://doi.org/10.1159/000360854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25138310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25138310"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Fangfang Liu, Danhua Shen, Xiaoping Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New tumour antigen PLAC1/CP1, a potentially useful prognostic marker and immunotherapy target for gastric adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jclinpath-2015-202978"}], "href": "https://doi.org/10.1136/jclinpath-2015-202978"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26157147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26157147"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yuan Wu, Xiaocong Lin, Xiaoqing Di, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic function of Plac1 on the proliferation and metastasis in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5272"}], "href": "https://doi.org/10.3892/or.2016.5272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27878289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27878289"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Mahboobeh Nazari, Amir-Hassan Zarnani, Roya Ghods, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Optimized protocol for soluble prokaryotic expression, purification and structural analysis of human placenta specific-1(PLAC1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Expr Purif (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pep.2017.03.011"}], "href": "https://doi.org/10.1016/j.pep.2017.03.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28315746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28315746"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Eric J Devor, Jesus Gonzalez-Bosquet, Akshaya Warrier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2017.3931"}], "href": "https://doi.org/10.3892/ijo.2017.3931"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28339050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28339050"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Arcangelo Liso, Francesca Massenzio, Fabrizio Stracci "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1 immunization does not induce infertility in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunotherapy (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/imt-2017-0019"}], "href": "https://doi.org/10.2217/imt-2017-0019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28351180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28351180"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Limin Guo, Donghai Xu, Yan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of circulating tumor cells by reverse transcription‑quantitative polymerase chain reaction and magnetic activated cell sorting in the peripheral blood of patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7372"}], "href": "https://doi.org/10.3892/mmr.2017.7372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849093"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Li Yang, Tian-Qi Zha, Xiang He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.6086"}], "href": "https://doi.org/10.3892/or.2017.6086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29138842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29138842"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Hongyan Yuan, Vincent Chen, Marc Boisvert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1 as a serum biomarker for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0192106"}], "href": "https://doi.org/10.1371/journal.pone.0192106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29432428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29432428"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Yongfei Li, Jiahui Chu, Jun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer/testis antigen-Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12311"}], "href": "https://doi.org/10.1002/1878-0261.12311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29704427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29704427"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Jiachi Ma, Lei Li, Jun Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placenta-specific protein 1 enhances liver metastatic potential and is associated with the PI3K/AKT/NF-κB signaling pathway in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer Prev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CEJ.0000000000000611"}], "href": "https://doi.org/10.1097/CEJ.0000000000000611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32701605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32701605"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Yu Ren, Yunxia Lv, Taiyuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of PLAC1 in colon cancer as a predictor of poor prognosis: A study based on TCGA data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2020.145072"}], "href": "https://doi.org/10.1016/j.gene.2020.145072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32827679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32827679"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Chuanbao Lin, Pengfei Qian, Yan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2020.101480"}], "href": "https://doi.org/10.1016/j.tice.2020.101480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33418237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33418237"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Ryusuke Hayashi, Toshihiro Nagato, Takumi Kumai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncoimmunology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/2162402X.2020.1856545"}], "href": "https://doi.org/10.1080/2162402X.2020.1856545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33457076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33457076"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Yifan Yu, Yong Xu, Wei Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression level of PLAC1 in osteosarcoma patients and its regulatory effect on the development of osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34077010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34077010"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Dongyang Liu, Ke Shi, Mingshi Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placenta-specific protein 1 promotes cell proliferation via the AKT/GSK-3β/cyclin D1 signaling pathway in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2514"}], "href": "https://doi.org/10.1002/iub.2514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34110086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34110086"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Rujun Chen, Chan Sheng, Ruyue Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAC1 is an independent predictor of poor survival, and promotes cell proliferation and invasion in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12440"}], "href": "https://doi.org/10.3892/mmr.2021.12440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34523695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34523695"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Eric J Devor, Donna A Santillan, Akshaya Warrier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placenta-specific protein 1 (PLAC1) expression is significantly down-regulated in preeclampsia "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " a hypoxia-mediated mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Matern Fetal Neonatal Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/14767058.2021.1977792"}], "href": "https://doi.org/10.1080/14767058.2021.1977792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34565269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34565269"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Zhijun Wang, Lei Deng, Xiwen Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer and its predictive value."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Gastroenterol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12876-023-02908-y"}], "href": "https://doi.org/10.1186/s12876-023-02908-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37568074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37568074"}]}]}]}