PLCD1 Gene

HGNC Family	EF-hand domain containing, Phospholipases, C2 domain containing
Name	phospholipase C, delta 1
Description	This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPLCD1, which maps to chromosome 3p22, functions as a potent tumor suppressor in a variety of solid tumors. In esophageal squamous cell carcinoma, its loss through DNA copy number reduction and promoter hypermethylation is associated with impaired cell‐cycle regulation, while in gastric and breast cancers epigenetic inactivation of PLCD1 correlates with enhanced cell migration and metastatic potential. In colorectal cancer, reduced PLCD1 expression—often linked with KRAS and TP53 mutations—disrupts β‐catenin signaling and autophagy regulation, and similar tumor‐suppressive effects have been observed in renal cell carcinoma. Collectively, these studies demonstrate that re‐establishment of PLCD1 function can induce cell cycle arrest (via p21, p27, and p53 upregulation), decrease phosphorylated Akt and matrix metalloprotease activities, and ultimately inhibit tumorigenicity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its tumor‐suppressive functions, PLCD1 is a central regulator of phosphoinositide signaling. By catalyzing the hydrolysis of phosphatidylinositol 4,5‐bisphosphate, it generates second messengers that are essential for calcium homeostasis, energy metabolism, and intracellular movement. PLCD1 exhibits dynamic subcellular distribution—for instance, it accumulates in the nucleus at the G1/S boundary and in quiescent cells, a process dependent on its pleckstrin homology domain."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Its catalytic activity and membrane association are tightly regulated by intramolecular allosteric interactions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and the properties of its PH domain confer high-affinity binding to PI(4,5)P2 as well as sensitivity to displacement by inositol 1,4,5‐trisphosphate."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Moreover, studies have shown that factors such as PLCβ2 can bind and inhibit PLCD1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", whereas direct interactions with the small GTPase Ral and calmodulin relieve such inhibition to activate PLCD1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " This intricate regulation extends to its role in receptor‐mediated signaling; for example, PLCD1 is necessary for TRPC4 channel activation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and participates in angiotensin II receptor–stimulated inositol phosphate production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " In the context of airway smooth muscle, PLCD1 is transcriptionally regulated by factors such as KLF15 and contributes to maintaining normal calcium and chloride transport."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in tumorigenesis and signal transduction, germline mutations in PLCD1 are linked to developmental disorders of the skin and its appendages. Pathogenic variants underlie hereditary leukonychia—an autosomal dominant nail dystrophy characterized by porcelain white nails—and have been identified in multiple populations, expanding the mutational spectrum observed in affected families."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": " Furthermore, a gain-of-function mutation in PLCD1 has been associated with the development of multiple pilomatricomas, and variants with increased enzymatic activity have been implicated in coronary spasm, underscoring the enzyme’s critical dosage-sensitive role in epithelial and vascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Fu, Yan-Ru Qin, Dan Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of a novel tumor-suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-2411"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-2411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18006814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18006814"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "X-T Hu, F-B Zhang, Y-C Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.92"}], "href": "https://doi.org/10.1038/onc.2009.92"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19448674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19448674"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tingxiu Xiang, Lili Li, Yichao Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLCD1 is a functional tumor suppressor inducing G(2)/M arrest and frequently methylated in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.10.5.12726"}], "href": "https://doi.org/10.4161/cbt.10.5.12726"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20657189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20657189"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Haixi Mu, Na Wang, Lijuan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of PLCD1 and adenovirus-mediated PLCD1 overexpression elicits a gene therapy effect on human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2015.01.017"}], "href": "https://doi.org/10.1016/j.yexcr.2015.01.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25655282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25655282"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stine A Danielsen, Lina Cekaite, Trude H Ågesen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0024419"}], "href": "https://doi.org/10.1371/journal.pone.0024419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21909432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21909432"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Makoto Shimozawa, Sakiho Anzai, Reiko Satow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C δ1 negatively regulates autophagy in colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.05.098"}], "href": "https://doi.org/10.1016/j.bbrc.2017.05.098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28528980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28528980"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jianlian Xie, Jun Zhou, Jiliang Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C delta 1 inhibits WNT/β-catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-023-01448-2"}], "href": "https://doi.org/10.1186/s13148-023-01448-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36849889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36849889"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jonathan D Stallings, Edward G Tall, Srinivas Pentyala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413813200"}], "href": "https://doi.org/10.1074/jbc.M413813200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15809301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15809301"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Michikazu Tanio, Katsuyuki Nishimura "}, {"type": "b", "children": [{"type": "t", "text": "Intramolecular allosteric interaction in the phospholipase C-δ1 pleckstrin homology domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbapap.2013.01.034"}], "href": "https://doi.org/10.1016/j.bbapap.2013.01.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23388389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23388389"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sang Bong Lee, Péter Várnai, Andras Balla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312772200"}], "href": "https://doi.org/10.1074/jbc.M312772200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15037625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15037625"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yoko Naito, Masashi Okada, Hitoshi Yagisawa "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C isoforms are localized at the cleavage furrow during cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvj209"}], "href": "https://doi.org/10.1093/jb/mvj209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17041247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17041247"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yuanjian Guo, Mario Rebecchi, Suzanne Scarlata "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase Cbeta2 binds to and inhibits phospholipase Cdelta1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M407593200"}], "href": "https://doi.org/10.1074/jbc.M407593200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15509571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15509571"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ranjinder S Sidhu, Richard R Clough, Rajinder P Bhullar "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M412966200"}], "href": "https://doi.org/10.1074/jbc.M412966200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15817490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15817490"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dhananjay P Thakur, Jin-bin Tian, Jaepyo Jeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1522294113"}], "href": "https://doi.org/10.1073/pnas.1522294113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26755577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26755577"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Christina M Godin, Lucimar T Ferreira, Lianne B Dale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The small GTPase Ral couples the angiotensin II type 1 receptor to the activation of phospholipase C-delta 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.109.061069"}], "href": "https://doi.org/10.1124/mol.109.061069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20018811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20018811"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sarah K Sasse, Vineela Kadiyala, Thomas Danhorn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2016-0357OC"}], "href": "https://doi.org/10.1165/rcmb.2016-0357OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28375666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28375666"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Chloé Grebert, Frédéric Becq, Clarisse Vandebrouck "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00437.2019"}], "href": "https://doi.org/10.1152/ajplung.00437.2019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33236921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33236921"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Maija Kiuru, Mazen Kurban, Munenari Itoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hereditary leukonychia, or porcelain nails, resulting from mutations in PLCD1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.05.014"}], "href": "https://doi.org/10.1016/j.ajhg.2011.05.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21665001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21665001"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shuzhan Shen, Minhua Shao, Uma Keyal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of two novel mutations in the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PLCD1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene in Chinese patients with hereditary leukonychia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12052"}], "href": "https://doi.org/10.3892/mmr.2021.12052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33786625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33786625"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ke Xue, Yajie Zheng, Changbing Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel PLCD1 mutation in Chinese Han pedigree with hereditary leukonychia and koilonychia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cosmet Dermatol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jocd.12707"}], "href": "https://doi.org/10.1111/jocd.12707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30003652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30003652"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Zekun Wang, Wenzhao Guan, Yufeng Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-023-11113-9"}], "href": "https://doi.org/10.1186/s12885-023-11113-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37460940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37460940"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yufu Wu, Qing Mao, Xiulin Liang "}, {"type": "b", "children": [{"type": "t", "text": "Targeting the MicroRNA-490-3p-ATG4B-Autophagy Axis Relieves Myocardial Injury in Ischemia Reperfusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cardiovasc Transl Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12265-020-09972-9"}], "href": "https://doi.org/10.1007/s12265-020-09972-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32474761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32474761"}]}]}]}
Synonyms	PLC-III, NDNC3
Proteins	PLCD1_HUMAN
NCBI Gene ID	5333
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PLCD1 has 8,714 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 131 datasets.

Click the + buttons to view associations for PLCD1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PLCD1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLCD1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLCD1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PLCD1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PLCD1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PLCD1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLCD1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving PLCD1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PLCD1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PLCD1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PLCD1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PLCD1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PLCD1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PLCD1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PLCD1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PLCD1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLCD1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PLCD1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PLCD1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with PLCD1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PLCD1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PLCD1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PLCD1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PLCD1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PLCD1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PLCD1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PLCD1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PLCD1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PLCD1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PLCD1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PLCD1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PLCD1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PLCD1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PLCD1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PLCD1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PLCD1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PLCD1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PLCD1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PLCD1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PLCD1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PLCD1 gene from the ENCODE Histone Modification Site Profiles dataset.