PLP2 Gene

Name	proteolipid protein 2 (colonic epithelium-enriched)
Description	This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPannexin proteins were first identified as a novel family of gap junction–related proteins that, unlike classical connexins, predominantly form single‐membrane channels rather than intercellular junctions. Early investigations demonstrated that these molecules—most notably Panx1 together with its paralogs Panx2 and Panx3—exhibit a broad expression pattern in the central nervous system and other tissues, and possess structural features reminiscent of invertebrate innexins. Their expression is dynamically regulated during development so that, for example, Panx1 is abundant in embryonic brain while Panx2 expression increases in postnatal maturation. These findings established the framework for understanding pannexins as versatile channel proteins."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA growing body of work has revealed that pannexin channels function as conduits for the release of signaling molecules—most prominently, adenosine triphosphate (ATP). Activation of these channels in diverse cell types leads to robust ATP efflux that is critical for paracrine communication. For instance, pannexin‐mediated ATP release has been shown to trigger caspase‐1 activation within the inflammasome complex, to mediate transmitter secretion in taste receptor cells, and to facilitate astrocytic calcium wave propagation. In neural tissue, pannexin activation contributes to pathological processes such as cortical spreading depression linked to migraine and to the modulation of neuronal excitability during seizures, while in epithelial cells their opening under mechanical stress enhances ATP release that coordinates mucociliary clearance. Collectively, these studies underscore the central role of pannexins in converting diverse extracellular or cytosolic signals into ATP‐based intercellular cues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond their role in ATP release and paracrine signaling, pannexin channels also participate in diverse cellular processes including the regulation of inflammation, apoptosis, and excitability. In various experimental models, pannexin activity has been implicated in mediating cell death through mechanisms such as pyroptosis and apoptotic ‘find‐me’ signaling, and in modulating vascular tone by promoting vasoconstriction in smooth muscle cells. Biochemical analyses have further revealed that post‐translational modifications, such as glycosylation and phosphorylation, regulate pannexin trafficking, channel gating, and interactions with other membrane proteins. These multifaceted functions highlight pannexins as pivotal integrators of extracellular signals that regulate both physiological and pathological cellular responses across multiple systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "25"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Roberto Bruzzone, Sheriar G Hormuzdi, Michael T Barbe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexins, a family of gap junction proteins expressed in brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2233464100"}], "href": "https://doi.org/10.1073/pnas.2233464100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14597722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14597722"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Arundhati Ray, Georg Zoidl, Svenja Weickert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Site-specific and developmental expression of pannexin1 in the mouse nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2005.04139.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2005.04139.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16026466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16026466"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Angelika Vogt, Sheriar G Hormuzdi, Hannah Monyer "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin1 and Pannexin2 expression in the developing and mature rat brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Mol Brain Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molbrainres.2005.08.002"}], "href": "https://doi.org/10.1016/j.molbrainres.2005.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16143426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16143426"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan Huang, Judith B Grinspan, Charles K Abrams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin1 is expressed by neurons and glia but does not form functional gap junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.20435"}], "href": "https://doi.org/10.1002/glia.20435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17009242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17009242"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "G Zoidl, E Petrasch-Parwez, A Ray, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2007.01.061"}], "href": "https://doi.org/10.1016/j.neuroscience.2007.01.061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17379420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17379420"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yi-Jen Huang, Yutaka Maruyama, Gennady Dvoryanchikov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0611280104"}], "href": "https://doi.org/10.1073/pnas.0611280104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17389364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17389364"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Thirumala-Devi Kanneganti, Mohamed Lamkanfi, Yun-Gi Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2007.03.008"}], "href": "https://doi.org/10.1016/j.immuni.2007.03.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17433728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17433728"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "George A Ransford, Nevis Fregien, Feng Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin 1 contributes to ATP release in airway epithelia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2008-0367OC"}], "href": "https://doi.org/10.1165/rcmb.2008-0367OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19213873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19213873"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Rodolfo Iglesias, Gerhard Dahl, Feng Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin 1: the molecular substrate of astrocyte \"hemichannels\"."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.6062-08.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.6062-08.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19474335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19474335"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ji-Eun Kim, Tae-Cheon Kang "}, {"type": "b", "children": [{"type": "t", "text": "The P2X7 receptor-pannexin-1 complex decreases muscarinic acetylcholine receptor-mediated seizure susceptibility in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI44818"}], "href": "https://doi.org/10.1172/JCI44818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21505260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21505260"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yan Qu, Shahram Misaghi, Kim Newton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1100478"}], "href": "https://doi.org/10.4049/jimmunol.1100478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21508259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21508259"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lucia Seminario-Vidal, Seiko F Okada, Juliana I Sesma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.260562"}], "href": "https://doi.org/10.1074/jbc.M111.260562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21606493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21606493"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Marcelo F Santiago, Jana Veliskova, Naman K Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting pannexin1 improves seizure outcome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0025178"}], "href": "https://doi.org/10.1371/journal.pone.0025178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21949881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21949881"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Joanna K Sandilos, Yu-Hsin Chiu, Faraaz B Chekeni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.323378"}], "href": "https://doi.org/10.1074/jbc.M111.323378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22311983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22311983"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hulya Karatas, Sefik Evren Erdener, Yasemin Gursoy-Ozdemir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spreading depression triggers headache by activating neuronal Panx1 channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1231897"}], "href": "https://doi.org/10.1126/science.1231897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23449592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23449592"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Alexander W Lohman, Igor L Leskov, Joshua T Butcher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8965"}], "href": "https://doi.org/10.1038/ncomms8965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26242575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26242575"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2019101638"}], "href": "https://doi.org/10.15252/embj.2019101638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30902848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30902848"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Silvia Penuela, Ruchi Bhalla, Xiang-Qun Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.009514"}], "href": "https://doi.org/10.1242/jcs.009514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17925379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17925379"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "R Iglesias, S Locovei, A Roque, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P2X7 receptor-Pannexin1 complex: pharmacology and signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00228.2008"}], "href": "https://doi.org/10.1152/ajpcell.00228.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18596211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18596211"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Roger J Thompson, Michael F Jackson, Michelle E Olah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1165209"}], "href": "https://doi.org/10.1126/science.1165209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19056988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19056988"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Silvia Penuela, Ruchi Bhalla, Kakon Nag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glycosylation regulates pannexin intermixing and cellular localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-01-0067"}], "href": "https://doi.org/10.1091/mbc.e09-01-0067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19692571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19692571"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Marie Billaud, Alexander W Lohman, Adam C Straub, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.110.237594"}], "href": "https://doi.org/10.1161/CIRCRESAHA.110.237594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21546608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21546608"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Panagiotis Bargiotas, Antje Krenz, Sheriar G Hormuzdi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pannexins in ischemia-induced neurodegeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1018262108"}], "href": "https://doi.org/10.1073/pnas.1018262108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22147915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22147915"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Sylvia O Suadicani, Rodolfo Iglesias, Junjie Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.22338"}], "href": "https://doi.org/10.1002/glia.22338"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22499153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22499153"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Kanchan Bisht, Kenneth A Okojie, Kaushik Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-25590-8"}], "href": "https://doi.org/10.1038/s41467-021-25590-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34489419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34489419"}]}]}]}
Synonyms	A4, A4LSB
Proteins	PLP2_HUMAN
NCBI Gene ID	5355
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PLP2 has 7,667 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for PLP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PLP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PLP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PLP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PLP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PLP2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PLP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PLP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PLP2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PLP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PLP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PLP2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PLP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PLP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PLP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PLP2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PLP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PLP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PLP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PLP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PLP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PLP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PLP2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PLP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PLP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PLP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PLP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PLP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PLP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PLP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PLP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PLP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PLP2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PLP2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PLP2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PLP2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of PLP2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.