{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPhospholipid phosphatase 4 (PLPP4), also known as PPAPDC1A, has been implicated in cancer malignancy, where its aberrant expression appears to contribute to tumor progression. In lung carcinoma, PLPP4 has been demonstrated to be involved in the malignant process, suggesting that it may serve as a biomarker of disease aggressiveness and could represent a potential therapeutic target by influencing lipid‐signaling pathways that drive lung cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn diffuse gastric cancer, recurrent gene fusions involving PLPP4—most notably the TACC2–PPAPDC1A in‐frame fusion—have been identified as being associated with a particularly aggressive tumor subset and poor prognosis. These fusion events point to a role for PLPP4 alterations in enhancing tumor invasiveness and migratory capacity, thereby defining a distinct molecular subgroup independent of other genomic instability events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin Zhang, Lan Zhang, Bihua Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-permeable Cationic Channel in lung carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-017-0717-5"}], "href": "https://doi.org/10.1186/s12943-017-0717-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28851360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28851360"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hanna Yang, Dongwan Hong, Soo Young Cho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-06747-4"}], "href": "https://doi.org/10.1038/s41467-018-06747-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30361512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30361512"}]}]}]}