PLTP Gene

HGNC Family	BPI fold containing (BPIF)
Name	phospholipid transfer protein
Description	The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPhospholipid transfer protein (PLTP) is increasingly recognized as a key regulator of lipoprotein metabolism. Genome‐wide association studies have linked common variants near PLTP with HDL cholesterol levels, suggesting its fundamental role in modulating circulating lipoproteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, PLTP expression is controlled by nuclear receptors such as the liver X receptors (LXRs), which, upon binding oxysterols or synthetic ligands, robustly induce PLTP transcription in hepatic cells and even in macrophages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " A comprehensive review of PLTP has further established its central role in plasma lipid and lipoprotein remodeling as well as its potential contribution to various human pathologies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cardiovascular disease, PLTP influences reverse cholesterol transport, HDL remodeling and the generation of pre–β-HDL particles that serve as efficient acceptors of cellular cholesterol. Genetic studies indicate that variants at the PLTP locus affect HDL particle concentration and may mediate cardiovascular risk"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while other investigations demonstrate that PLTP may directly participate in atherosclerotic lesion development by modulating the hepatic secretion of apoB-containing lipoproteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Expression of PLTP in macrophages has been detected in human atherosclerotic plaques, and cholesterol loading in these cells upregulates both PLTP mRNA and protein."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In aortic stenosis, elevated levels of PLTP—as induced by matrix proteins such as biglycan via Toll-like receptor 2—further underscore its link with pathological lipid retention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Comparative studies on PLTP and the related cholesteryl ester transfer protein have shown that high PLTP activity (despite being associated with increased HDL cholesterol) does not necessarily protect against cardiovascular disease"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and experimental data in animal models illustrate that enhanced PLTP activity facilitates cholesterol clearance as well as plasma lipoprotein conversion processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Furthermore, hepatic cell models have demonstrated that secreted PLTP, which coelutes with apoE-containing complexes, exists in a high–activity form that is critical for transferring phospholipids between lipoproteins"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while mechanistic studies reveal that PLTP plays a major role in recycling pre–β-HDL and in mediating cholesterol efflux from macrophages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Structural analyses further indicate that a specific PLTP α-helical segment is critical for interactions with ABCA1 and for stabilizing the lipid domains necessary for cholesterol mobilization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its systemic roles, PLTP expression and activity have been described in other tissues, suggesting additional layers of physiological relevance. Recent reviews highlight exciting advances in the understanding of PLTP in lipoprotein remodeling and its connection with reverse cholesterol transport."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In the central nervous system, PLTP is abundantly expressed and altered PLTP activity in cerebrospinal fluid correlates with changes in apolipoprotein E levels, providing a potential link to neurodegenerative processes such as Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " In transgenic animal models, forced expression of human PLTP leads to marked reductions in HDL and increased atherosclerosis, implying that heightened PLTP activity may adversely affect cardiovascular health."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " In a novel context, PLTP is also present in human tear fluid, where its phospholipid transfer activity—comparable or even higher than that found in plasma—suggests a role in maintaining ocular surface lipid homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sekar Kathiresan, Cristen J Willer, Gina M Peloso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants at 30 loci contribute to polygenic dyslipidemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.291"}], "href": "https://doi.org/10.1038/ng.291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19060906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19060906"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bryan A Laffitte, Sean B Joseph, Mingyi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.6.2182-2191.2003"}], "href": "https://doi.org/10.1128/MCB.23.6.2182-2191.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12612088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12612088"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "John J Albers, Simona Vuletic, Marian C Cheung "}, {"type": "b", "children": [{"type": "t", "text": "Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2011.06.013"}], "href": "https://doi.org/10.1016/j.bbalip.2011.06.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21736953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21736953"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Menno Vergeer, S Matthijs Boekholdt, Manjinder S Sandhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.109.912519"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.109.912519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20644014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20644014"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kevin D O'Brien, Simona Vuletic, Thomas O McDonald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000079163.97653.CD"}], "href": "https://doi.org/10.1161/01.CIR.0000079163.97653.CD"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12835223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12835223"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Catherine M Desrumaux, Puiying A Mak, William A Boisvert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M200281-JLR200"}], "href": "https://doi.org/10.1194/jlr.M200281-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12730304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12730304"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Habib Derbali, Yohan Bossé, Nancy Côté, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2010.090541"}], "href": "https://doi.org/10.2353/ajpath.2010.090541"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20382708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20382708"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sander J Robins, Asya Lyass, Robert W Brocia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma lipid transfer proteins and cardiovascular disease. The Framingham Heart Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2013.01.046"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2013.01.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23477743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23477743"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sabine M Post, Rini de Crom, Rien van Haperen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased fecal bile acid excretion in transgenic mice with elevated expression of human phospholipid transfer protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.ATV.0000067702.22390.20"}], "href": "https://doi.org/10.1161/01.ATV.0000067702.22390.20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12649089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12649089"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sarah Siggins, Matti Jauhiainen, Vesa M Olkkonen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M300059-JLR200"}], "href": "https://doi.org/10.1194/jlr.M300059-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12810820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12810820"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yasushi Nakamura, Leila Kotite, Yonghong Gan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi0485629"}], "href": "https://doi.org/10.1021/bi0485629"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15544352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15544352"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Riikka Vikstedt, Jari Metso, Jukka Hakala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi700833h"}], "href": "https://doi.org/10.1021/bi700833h"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17900150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17900150"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "John F Oram, Gertrud Wolfbauer, Chongren Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M800117200"}], "href": "https://doi.org/10.1074/jbc.M800117200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18287097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18287097"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "John J Albers, Marian C Cheung "}, {"type": "b", "children": [{"type": "t", "text": "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Opin Lipidol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00041433-200406000-00004"}], "href": "https://doi.org/10.1097/00041433-200406000-00004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15166780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15166780"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Simona Vuletic, Elaine R Peskind, Santica M Marcovina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.20458"}], "href": "https://doi.org/10.1002/jnr.20458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15795933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15795933"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jessica Lie, Rini de Crom, Teus van Gent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M300487-JLR200"}], "href": "https://doi.org/10.1194/jlr.M300487-JLR200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14993244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14993244"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hannelore Samyn, Matthijs Moerland, Teus van Gent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevation of systemic PLTP, but not macrophage-PLTP, impairs macrophage reverse cholesterol transport in transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2008.10.020"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2008.10.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19100548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19100548"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Matti Jauhiainen, Niko L Setälä, Christian Ehnholm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipid transfer protein is present in human tear fluid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi050151k"}], "href": "https://doi.org/10.1021/bi050151k"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15924430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15924430"}]}]}]}
Synonyms	BPIFE, HDLCQ9
Proteins	PLTP_HUMAN
NCBI Gene ID	5360
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PLTP has 11,964 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for PLTP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PLTP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLTP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLTP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PLTP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PLTP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PLTP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PLTP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PLTP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PLTP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PLTP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PLTP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PLTP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PLTP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PLTP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PLTP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLTP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PLTP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PLTP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PLTP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PLTP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PLTP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PLTP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PLTP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PLTP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PLTP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PLTP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PLTP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PLTP gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PLTP gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PLTP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PLTP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PLTP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PLTP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PLTP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PLTP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PLTP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLTP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PLTP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PLTP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PLTP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PLTP gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.