PLXNB1 Gene

HGNC Family Plexins (PLXN)
Name plexin B1
Description Enables semaphorin receptor activity. Involved in several processes, including negative regulation of cell adhesion; regulation of cell shape; and semaphorin-plexin signaling pathway. Located in plasma membrane. Part of semaphorin receptor complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPlexin‐B1 (PLXNB1) acts as a transmembrane receptor for several semaphorins—most notably Semaphorin 4D—and is a key mediator of diverse signaling events. In both developing neural tissues and endothelial cells, PLXNB1 transduces semaphorin cues to regulate axon guidance as well as angiogenesis. Its activation by semaphorins triggers repulsive responses in neuronal growth cones while simultaneously promoting proangiogenic events in vascular endothelium."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, PLXNB1 orchestrates intracellular signaling through direct interactions with small GTPases and Rho guanine nucleotide exchange factors. Binding of active Rac, Rho, R-Ras, and M-Ras to distinct regions of its cytoplasmic domain drives cytoskeletal reorganization, integrin‐dependent adhesion, and growth cone collapse. Moreover, coupling with receptor tyrosine kinases—such as Met, Ron, and ErbB‐2—further modulates downstream cascades including the PI3K–Akt and MAPK pathways, ultimately balancing bidirectional signals that can promote or inhibit cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of PLXNB1 signaling has been widely implicated in tumor biology. In several cancer types—including melanoma, prostate, pancreatic, and glioma—alterations in PLXNB1 expression, mutational status, or its association with partner proteins (for example, through proteolytic processing or microRNA regulation) contribute to either oncogenic or tumor‐suppressive outcomes. Depending on the cellular context, PLXNB1 can inhibit oncogenic receptor activation (such as c‐Met) and reduce integrin–FAK signaling, thereby suppressing proliferation and invasion, or it can facilitate tumor cell migration, invasion and angiogenesis by activating RhoA and other downstream effectors. Thus, PLXNB1 plays a pivotal role in mediating invasive growth, metastasis and the tumor microenvironment, with its expression levels correlating with clinical prognosis in various cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPLXNB1 function is further refined by post‐translational mechanisms—including proteolytic conversion and interactions with specific Rho proteins—and by its integration within broader tissue-specific signaling networks. Mutation in PLXNB1’s regulatory domains can alter its binding to Rac and Rnd family proteins, impacting the assembly of signaling complexes that control cell motility, differentiation, endometrial adhesiveness, and even stem cell conversion. Additionally, PLXNB1 signaling has been implicated in non‐neoplastic settings such as trophoblast invasion in placentation and dental pulp stem cell differentiation toward endothelial lineages, underscoring its diverse physiologic and pathophysiologic roles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paolo Conrotto, Donatella Valdembri, Simona Corso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4D induces angiogenesis through Met recruitment by Plexin B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-07-2885"}], "href": "https://doi.org/10.1182/blood-2004-07-2885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15632204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15632204"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "John R Basile, Talayeh Afkhami, J Silvio Gutkind "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.16.6889-6898.2005"}], "href": "https://doi.org/10.1128/MCB.25.16.6889-6898.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16055703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16055703"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "John R Basile, Julie Gavard, J Silvio Gutkind "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M705467200"}], "href": "https://doi.org/10.1074/jbc.M705467200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17855350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17855350"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bert J C Janssen, Ross A Robinson, Francesc Pérez-Brangulí, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of semaphorin-plexin signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09468"}], "href": "https://doi.org/10.1038/nature09468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20877282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20877282"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Haris G Vikis, Weiquan Li, Kun-Liang Guan "}, {"type": "b", "children": [{"type": "t", "text": "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.966402"}], "href": "https://doi.org/10.1101/gad.966402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11937491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11937491"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mutsumi Hirotani, Yoshiharu Ohoka, Takahiro Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(02)02122-8"}], "href": "https://doi.org/10.1016/s0006-291x(02"}, {"type": "t", "text": "02122-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12220504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12220504"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yufeng Tong, Preeti Chugha, Prasanta K Hota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M703800200"}], "href": "https://doi.org/10.1074/jbc.M703800200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17916560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17916560"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Oscar Gee-Wan Wong, Tharani Nitkunan, Izumi Oinuma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1 mutations in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0702544104"}], "href": "https://doi.org/10.1073/pnas.0702544104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18024597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18024597"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jakub M Swiercz, Thomas Worzfeld, Stefan Offermanns "}, {"type": "b", "children": [{"type": "t", "text": "ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706822200"}], "href": "https://doi.org/10.1074/jbc.M706822200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18025083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18025083"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "S Bouguet-Bonnet, M Buck "}, {"type": "b", "children": [{"type": "t", "text": "Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2008.01.081"}], "href": "https://doi.org/10.1016/j.jmb.2008.01.081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18321527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18321527"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Izumi Oinuma, Yuri Ito, Hironori Katoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.147546"}], "href": "https://doi.org/10.1074/jbc.M110.147546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20610402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20610402"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Luisa Granziero, Paola Circosta, Cristina Scielzo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-05-1339"}], "href": "https://doi.org/10.1182/blood-2002-05-1339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12406905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12406905"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Paolo Conrotto, Simona Corso, Sara Gamberini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interplay between scatter factor receptors and B plexins controls invasive growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207650"}], "href": "https://doi.org/10.1038/sj.onc.1207650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15184888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15184888"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "A Rody, T Karn, U Holtrich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "\"Stem cell like\" breast cancers-a model for the identification of new prognostic/predictive markers in endocrine responsive breast cancer exemplified by Plexin B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Obstet Gynecol Reprod Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejogrb.2008.02.015"}], "href": "https://doi.org/10.1016/j.ejogrb.2008.02.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18417270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18417270"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yasuhiro Saito, Izumi Oinuma, Satoshi Fujimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2009.63"}], "href": "https://doi.org/10.1038/embor.2009.63"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19444311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19444311"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "G M Argast, C H Croy, K L Couts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.133"}], "href": "https://doi.org/10.1038/onc.2009.133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19483722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19483722"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Guido Valente, Giuseppina Nicotra, Marisa Arrondini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CLO-2009-0504"}], "href": "https://doi.org/10.3233/CLO-2009-0504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19940359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19940359"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Lindy McClelland, Yulin Chen, Joanne Soong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin B1 inhibits integrin-dependent pp125FAK and Rho activity in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pigment Cell Melanoma Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1755-148X.2010.00797.x"}], "href": "https://doi.org/10.1111/j.1755-148X.2010.00797.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21029396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21029396"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ran Qiang, Fang Wang, Li-Ying Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2011.01.002"}], "href": "https://doi.org/10.1016/j.biocel.2011.01.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21216304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21216304"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Shingo Kato, Kensuke Kubota, Takeshi Shimamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Semaphorin 4D, a lymphocyte semaphorin, enhances tumor cell motility through binding its receptor, plexinB1, in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2011.02053.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2011.02053.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21812859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21812859"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Chun Zhou, Oscar Gee-Wan Wong, John R Masters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of cancer-associated mutations in the PlexinB1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-11-11"}], "href": "https://doi.org/10.1186/1476-4598-11-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22404908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22404908"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "M Williamson, P de Winter, J R Masters "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1 signalling promotes androgen receptor translocation to the nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2015.160"}], "href": "https://doi.org/10.1038/onc.2015.160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25982277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25982277"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Bide Liu, Xiao Gu, Tianbao Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of TMPRSS2-ERG mechanisms in prostate cancer invasiveness: Involvement of MMP-9 and plexin B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5277"}], "href": "https://doi.org/10.3892/or.2016.5277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28004109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28004109"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Guanlin Li, Liyang Ma, Huifen Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hypertens (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/HJH.0000000000001808"}], "href": "https://doi.org/10.1097/HJH.0000000000001808"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29939944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29939944"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Magali Williamson, Ritu Garg, Claire M Wells "}, {"type": "b", "children": [{"type": "t", "text": "PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9010003"}], "href": "https://doi.org/10.3390/cells9010003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31861264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31861264"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Stefania Artigiani, Davide Barberis, Pietro Fazzari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional regulation of semaphorin receptors by proprotein convertases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M210156200"}], "href": "https://doi.org/10.1074/jbc.M210156200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12533544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12533544"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jakub M Swiercz, Rohini Kuner, Stefan Offermanns "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200312094"}], "href": "https://doi.org/10.1083/jcb.200312094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15210733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15210733"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Haggar Harduf, Shlomit Goldman, Eliezer Shalev "}, {"type": "b", "children": [{"type": "t", "text": "Human uterine epithelial RL95-2 and HEC-1A cell-line adhesiveness: the role of plexin B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fertil Steril (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fertnstert.2006.11.141"}], "href": "https://doi.org/10.1016/j.fertnstert.2006.11.141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17383649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17383649"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Michal Amir, Shabtai Romano, Shlomit Goldman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1, glycodelin and MMP7 expression in the human fallopian tube and in the endometrium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1477-7827-7-152"}], "href": "https://doi.org/10.1186/1477-7827-7-152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20040080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20040080"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Eyad Kalawy Fansa, Radovan Dvorsky, Si-Cai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction characteristics of Plexin-B1 with Rho family proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.04.012"}], "href": "https://doi.org/10.1016/j.bbrc.2013.04.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23603360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23603360"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Adebiyi Damola, Anne Legendre, Stephen Ball, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function of mutant and wild-type plexinb1 in prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.22678"}], "href": "https://doi.org/10.1002/pros.22678"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23775445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23775445"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Muhammad Faraz Arshad Malik, Lin Ye, Wen G Jiang "}, {"type": "b", "children": [{"type": "t", "text": "Reduced expression of semaphorin 4D and plexin-B in breast cancer is associated with poorer prognosis and the potential linkage with oestrogen receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4015"}], "href": "https://doi.org/10.3892/or.2015.4015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26035216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26035216"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jiao Cao, Chen Zhang, Ting Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1 and semaphorin 4D cooperate to promote cutaneous squamous cell carcinoma cell proliferation, migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dermatol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jdermsci.2015.05.002"}], "href": "https://doi.org/10.1016/j.jdermsci.2015.05.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26051877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26051877"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "R Joseph Bender, Feilim Mac Gabhann "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulation of the vascular endothelial growth factor and semaphorin ligand-receptor families in prostate cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Syst Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12918-015-0201-z"}], "href": "https://doi.org/10.1186/s12918-015-0201-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26341082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26341082"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Yingwei Chang, Li Li, Luping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plexin-B1 indirectly affects glioma invasiveness and angiogenesis by regulating the RhoA/αvβ3 signaling pathway and SRPK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-4849-9"}], "href": "https://doi.org/10.1007/s13277-016-4849-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26944058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26944058"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Tetsuro Ikeya, Kiyoshi Maeda, Hisashi Nagahara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The combined expression of Semaphorin4D and PlexinB1 predicts disease recurrence in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-016-2577-6"}], "href": "https://doi.org/10.1186/s12885-016-2577-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27456345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27456345"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Thomas Wylie, Ritu Garg, Anne J Ridley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0185899"}], "href": "https://doi.org/10.1371/journal.pone.0185899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29040270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29040270"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Ting Zou, Shan Jiang, Waruna Lakmal Dissanayaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4D/PlexinB1 promotes endothelial differentiation of dental pulp stem cells via activation of AKT and ERK1/2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28635"}], "href": "https://doi.org/10.1002/jcb.28635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30937968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30937968"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Changhui Li, Lei Wan, Peng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sema4D/Plexin-B1 promotes the progression of osteosarcoma cells by activating Pyk2-PI3K-AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Musculoskelet Neuronal Interact (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34854398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34854398"}]}]}]}
Synonyms PLEXIN-B1, PLXN5, SEP
Proteins PLXB1_HUMAN
NCBI Gene ID 5364
API
Download Associations
Predicted Functions View PLXNB1's ARCHS4 Predicted Functions.
Co-expressed Genes View PLXNB1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PLXNB1's ARCHS4 Predicted Functions.

Functional Associations

PLXNB1 has 6,462 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for PLXNB1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by PLXNB1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of PLXNB1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of PLXNB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of PLXNB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of PLXNB1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of PLXNB1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PLXNB1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PLXNB1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of PLXNB1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of PLXNB1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with PLXNB1 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with PLXNB1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLXNB1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of PLXNB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of PLXNB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PLXNB1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing PLXNB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing PLXNB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with PLXNB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with PLXNB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
CORUM Protein Complexes protein complexs containing PLXNB1 protein from the CORUM Protein Complexes dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of PLXNB1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with PLXNB1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Disease Associations diseases associated with PLXNB1 gene/protein from the curated CTD Gene-Disease Associations dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of PLXNB1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by PLXNB1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving PLXNB1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with PLXNB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with PLXNB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with PLXNB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with PLXNB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PLXNB1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PLXNB1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of PLXNB1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing PLXNB1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with PLXNB1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with PLXNB1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of PLXNB1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with PLXNB1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing PLXNB1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of PLXNB1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PLXNB1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of PLXNB1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PLXNB1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of PLXNB1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of PLXNB1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GlyGen Glycosylated Proteins ligands (chemical) binding PLXNB1 protein from the GlyGen Glycosylated Proteins dataset.
GO Biological Process Annotations 2015 biological processes involving PLXNB1 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving PLXNB1 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving PLXNB1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing PLXNB1 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by PLXNB1 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by PLXNB1 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by PLXNB1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of PLXNB1 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of PLXNB1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of PLXNB1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PLXNB1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of PLXNB1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWASdb SNP-Disease Associations diseases associated with PLXNB1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with PLXNB1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of PLXNB1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for PLXNB1 protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of PLXNB1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of PLXNB1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of PLXNB1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PLXNB1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for PLXNB1 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with PLXNB1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by PLXNB1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for PLXNB1 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of PLXNB1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate PLXNB1 protein from the curated KEA Substrates of Kinases dataset.
KEGG Pathways pathways involving PLXNB1 protein from the KEGG Pathways dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate PLXNB1 protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of PLXNB1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of PLXNB1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with PLXNB1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of PLXNB1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of PLXNB1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of PLXNB1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PLXNB1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing PLXNB1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain PLXNB1 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by PLXNB1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting PLXNB1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of PLXNB1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of PLXNB1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by PLXNB1 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of PLXNB1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of PLXNB1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing PLXNB1 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
PANTHER Pathways pathways involving PLXNB1 protein from the PANTHER Pathways dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for PLXNB1 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PLXNB1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of PLXNB1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving PLXNB1 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving PLXNB1 protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with PLXNB1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate PLXNB1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
Reactome Pathways 2014 pathways involving PLXNB1 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving PLXNB1 protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of PLXNB1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PLXNB1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PLXNB1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of PLXNB1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of PLXNB1 gene from the RummaGEO Gene Perturbation Signatures dataset.
SynGO Synaptic Gene Annotations synaptic terms associated with PLXNB1 gene from the SynGO Synaptic Gene Annotations dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of PLXNB1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of PLXNB1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of PLXNB1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of PLXNB1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of PLXNB1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of PLXNB1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of PLXNB1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of PLXNB1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with PLXNB1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with PLXNB1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving PLXNB1 protein from the Wikipathways Pathways 2014 dataset.