{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPLXNB2, a member of the plexin receptor family, transduces semaphorin‐mediated guidance cues that are essential for axon pathfinding, cell migration, and cytoskeletal reorganization. Its extracellular domain undergoes regulated proteolytic processing to yield a mature, heterodimeric receptor with enhanced ligand-binding affinity. Moreover, structural studies have demonstrated that PLXNB2 forms specific interaction interfaces with PDZ‐domain–containing effectors (such as PDZ‑RhoGEF) and atypical Rho GTPases including Rnd proteins, thereby fine‑tuning downstream RhoA signaling and modulating cell morphology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPLXNB2 has emerged as a critical mediator in diverse malignancies. In malignant gliomas and glioblastomas, its upregulation drives actin cytoskeletal remodeling, invasive migration, and tumor vascularization, correlating with poor patient survival. In breast and ovarian carcinomas, PLXNB2 signaling—often in conjunction with semaphorin ligands such as Sema4C—promotes cell proliferation, epithelial–mesenchymal transitions, and metastatic progression, while aberrant expression in acute myeloid leukemia implicates it as a potential prognostic biomarker. Recent in vivo investigations even identify PLXNB2 as a host‐derived regulator that facilitates liver colonization during metastatic seeding."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in tumor biology, PLXNB2 plays multifaceted functions in immune regulation, apoptotic clearance, and tissue development. Interactions between PLXNB2 and its ligands (for example, CD100) promote leukocyte–endothelial adhesion and amplify inflammatory cascades in vascular and skin disorders such as psoriasis. In apoptotic monocytes, PLXNB2 is enriched in membrane‐bound vesicles and is required for the formation of beaded apoptopodia that facilitate efficient phagocytic clearance. In reproductive and respiratory epithelia, PLXNB2 contributes to cellular adhesion and barrier integrity (as seen in the endometrium and in exosome‐mediated airway inflammation). Furthermore, emerging evidence illustrates that PLXNB2 orchestrates actomyosin contractility and cell–matrix adhesion in stem and progenitor cells, thereby influencing neuroepithelial morphogenesis, osteogenic differentiation, and gastrointestinal barrier regeneration—functions that are also linked to its activity as the receptor for angiogenin, which modulates intracellular RNA processing to support cell survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "23"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Valerie Perrot, Jose Vazquez-Prado, J Silvio Gutkind "}, {"type": "b", "children": [{"type": "t", "text": "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206005200"}], "href": "https://doi.org/10.1074/jbc.M206005200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12183458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12183458"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stefania Artigiani, Davide Barberis, Pietro Fazzari, et al. 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