POLR2J4 Gene

Name	polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMEIOC is a meiosis‐specific factor that plays a pivotal role in extending the duration of meiotic prophase I, ensuring that critical chromosomal events – including homolog pairing, synapsis, and recombination – occur correctly. In mouse germ cells, MEIOC is up‐regulated upon the initiation of meiosis and is essential for maintaining a prolonged meiotic prophase by preventing premature chromosomal condensation and spindle assembly that would otherwise trigger a mitosis‐like cell cycle transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDis primis, MEIOC functions through a post‐transcriptional mechanism by interacting with RNA helicases such as YTHDC2. This interaction facilitates the stabilization of a subset of meiotic transcripts that would normally be degraded in a mitotic setting, thereby ensuring that the germ cells programmatically commit to a bona fide meiotic cell cycle rather than reverting to a mitotic program marked by proteins like CYCLIN A2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nFusce class, the role of MEIOC transcends mere transcript stabilization; its timely induction at the onset of meiosis—independent of retinoic acid and STRA8 signalling—represents an evolutionarily conserved mechanism. This dual-layer control, integrating both transcriptional and post-transcriptional regulatory pathways, is necessary to safeguard fertility by ensuring the proper execution of meiotic events in both male and female germ cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Emilie Abby, Sophie Tourpin, Jonathan Ribeiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10324"}], "href": "https://doi.org/10.1038/ncomms10324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26742488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26742488"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y Q Shirleen Soh, Maria M Mikedis, Mina Kojima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meioc maintains an extended meiotic prophase I in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006704"}], "href": "https://doi.org/10.1371/journal.pgen.1006704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28380054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28380054"}]}]}]}
Synonyms	RPB11-PHI
NCBI Gene ID	84820
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

POLR2J4 has 2,967 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 39 datasets.

Click the + buttons to view associations for POLR2J4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

POLR2J4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by POLR2J4 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of POLR2J4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of POLR2J4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of POLR2J4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of POLR2J4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of POLR2J4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of POLR2J4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of POLR2J4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with POLR2J4 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of POLR2J4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of POLR2J4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of POLR2J4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of POLR2J4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at POLR2J4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of POLR2J4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of POLR2J4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing POLR2J4 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of POLR2J4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of POLR2J4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of POLR2J4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of POLR2J4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of POLR2J4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of POLR2J4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of POLR2J4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of POLR2J4 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GWASdb SNP-Disease Associations	diseases associated with POLR2J4 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
	GWASdb SNP-Phenotype Associations	phenotypes associated with POLR2J4 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of POLR2J4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of POLR2J4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	cell lines with high or low expression of POLR2J4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	transcription factor perturbations changing expression of POLR2J4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	small molecule perturbations changing expression of POLR2J4 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	gene perturbations changing expression of POLR2J4 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain POLR2J4 protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of POLR2J4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	gene perturbations changing expression of POLR2J4 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at POLR2J4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of POLR2J4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores	tissues with high expression of POLR2J4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.