POLR3B Gene

HGNC Family	RNA polymerase subunits (POLR)
Name	polymerase (RNA) III (DNA directed) polypeptide B
Description	This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPOLR3B encodes the second‐largest subunit of RNA polymerase III, an essential enzyme that transcribes a variety of small noncoding RNAs—including 5S ribosomal RNA, transfer RNAs, and U6 small nuclear RNA—that are critical for ribosome biogenesis, RNA processing, and overall cellular protein synthesis. In complex with the largest subunit POLR3A, POLR3B helps form the catalytic core of Pol III, thereby ensuring efficient and accurate transcription of its target genes. This fundamental role in basic RNA metabolism underlies the enzyme’s impact on cell growth and proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations in POLR3B disrupt Pol III activity and have been strongly implicated in a spectrum of neurodegenerative disorders, most notably the hypomyelinating leukodystrophy syndromes—including 4H leukodystrophy—which are characterized by diffuse hypomyelination, cerebellar atrophy, oligodontia, and hypogonadotropic hypogonadism. Both recessive and de novo mutations in POLR3B have been associated with diverse clinical phenotypes ranging from relatively mild forms of 4H leukodystrophy to severe presentations with ataxia, spasticity, intellectual disability, epilepsy, and peripheral demyelinating neuropathies. Detailed genotype–phenotype studies have revealed that deleterious changes in POLR3B, including missense mutations, splice‐site alterations, and even large exonic deletions, all lead to disruption of the core transcriptional functions of Pol III and thereby compromise the biosynthesis of essential small RNAs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "19"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in RNA transcription, alternative products and derived fragments from the POLR3B gene—such as the protein INMAP, which represents a truncated version of POLR3B—have been shown to play critical roles in mitotic spindle formation, centromere regulation, and maintenance of genomic stability. Studies demonstrate that abnormal expression or mutation of these POLR3B‐related proteins can lead to defective spindle assembly, cell‐cycle arrest, chromosomal aberrations, and apoptosis—linking disturbances in Pol III function not only to neurodegenerative and developmental disorders but also to broader disruptions in cell proliferation and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "24"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ping Hu, Si Wu, Yuling Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.22.8044-8055.2002"}], "href": "https://doi.org/10.1128/MCB.22.22.8044-8055.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12391170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12391170"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hirotomo Saitsu, Hitoshi Osaka, Masayuki Sasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.10.003"}], "href": "https://doi.org/10.1016/j.ajhg.2011.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22036171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22036171"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Richa Ahuja, Vijay Kumar "}, {"type": "b", "children": [{"type": "t", "text": "Stimulation of Pol III-dependent 5S rRNA and U6 snRNA gene expression by AP-1 transcription factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.14104"}], "href": "https://doi.org/10.1111/febs.14104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28488757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28488757"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nicole I Wolf, Adeline Vanderver, Rosalina M L van Spaendonk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical spectrum of 4H leukodystrophy caused by POLR3A and POLR3B mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000001002"}], "href": "https://doi.org/10.1212/WNL.0000000000001002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25339210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25339210"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Martine Tétreault, Karine Choquet, Simona Orcesi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.10.006"}], "href": "https://doi.org/10.1016/j.ajhg.2011.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22036172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22036172"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hussein Daoud, Martine Tétreault, William Gibson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2012-101357"}], "href": "https://doi.org/10.1136/jmedgenet-2012-101357"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23355746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23355746"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Roberta La Piana, Ferdy K Cayami, Luan T Tran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diffuse hypomyelination is not obligate for POLR3-related disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000002612"}], "href": "https://doi.org/10.1212/WNL.0000000000002612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27029625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27029625"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mary R Richards, Lacey Plummer, Yee-Ming Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotypic spectrum of POLR3B mutations: isolated hypogonadotropic hypogonadism without neurological or dental anomalies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2016-104064"}], "href": "https://doi.org/10.1136/jmedgenet-2016-104064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27512013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27512013"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Félixe Pelletier, Stefanie Perrier, Ferdy K Cayami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endocrine and Growth Abnormalities in 4H Leukodystrophy Caused by Variants in POLR3A, POLR3B, and POLR1C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/clinem/dgaa700"}], "href": "https://doi.org/10.1210/clinem/dgaa700"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33005949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33005949"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jun-ichi Takanashi, Hitoshi Osaka, Hirotomo Saitsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Different patterns of cerebellar abnormality and hypomyelination between POLR3A and POLR3B mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Dev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.braindev.2013.03.006"}], "href": "https://doi.org/10.1016/j.braindev.2013.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23643445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23643445"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mariana Gutierrez, Isabelle Thiffault, Kether Guerrero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Large exonic deletions in POLR3B gene cause POLR3-related leukodystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Orphanet J Rare Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13023-015-0279-9"}], "href": "https://doi.org/10.1186/s13023-015-0279-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26045207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26045207"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Djurdja Djordjevic, Maxime Pinard, Marie-Soleil Gauthier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo variants in POLR3B cause ataxia, spasticity, and demyelinating neuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2020.12.002"}], "href": "https://doi.org/10.1016/j.ajhg.2020.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33417887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33417887"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ferdy K Cayami, Roberta La Piana, Rosalina M L van Spaendonk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POLR3A and POLR3B Mutations in Unclassified Hypomyelination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropediatrics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-0035-1550148"}], "href": "https://doi.org/10.1055/s-0035-1550148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26011300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26011300"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jamal Ghoumid, Florence Petit, Odile Boute-Benejean, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cerebellar hypoplasia with endosteal sclerosis is a POLR3-related disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2017.73"}], "href": "https://doi.org/10.1038/ejhg.2017.73"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28589944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28589944"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jan Kulhánek, Klára Brožová, Hana Hansíková, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POLR3B-associated leukodystrophy: clinical, neuroimaging and molecular-genetic analyses in four patients: clinical heterogeneity and novel mutations in POLR3B gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurol Neurochir Pol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5603/PJNNS.a2019.0042"}], "href": "https://doi.org/10.5603/PJNNS.a2019.0042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31577365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31577365"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Mostafa Saghi, Kolsoum InanlooRahatloo, Afagh Alavi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intellectual disability associated with craniofacial dysmorphism due to POLR3B mutation and defect in spliceosomal machinery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-022-01237-5"}], "href": "https://doi.org/10.1186/s12920-022-01237-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35436926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35436926"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hengzhou Bai, Dingming Li, Yi Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Case report: Biallelic variants in POLR3B gene lead to 4H leukodystrophy from the study of brother and sister."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000030350"}], "href": "https://doi.org/10.1097/MD.0000000000030350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36042647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36042647"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Masahiro Ando, Yujiro Higuchi, Jun-Hui Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel de novo POLR3B mutations responsible for demyelinating Charcot-Marie-Tooth disease in Japan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Transl Neurol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/acn3.51555"}], "href": "https://doi.org/10.1002/acn3.51555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35482004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35482004"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Alessandro Geroldi, Stefano Tozza, Chiara Fiorillo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel de novo variant in POLR3B gene associated with a primary axonal involvement of the largest nerve fibers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Peripher Nerv Syst (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jns.12602"}], "href": "https://doi.org/10.1111/jns.12602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37897416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37897416"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Enzhi Shen, Yan Lei, Qian Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of INMAP, a novel interphase nucleus and mitotic apparatus protein that is involved in spindle formation and cell cycle progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2009.01.022"}], "href": "https://doi.org/10.1016/j.yexcr.2009.01.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19331820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19331820"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Eline A Verberne, Lotje Dalen Meurs, Nicole I Wolf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "4H leukodystrophy caused by a homozygous POLR3B mutation: Further delineation of the phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61600"}], "href": "https://doi.org/10.1002/ajmg.a.61600"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32319736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32319736"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zhou Yunlei, Chen Zhe, Lei Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "INMAP, a novel truncated version of POLR3B, represses AP-1 and p53 transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-012-1507-4"}], "href": "https://doi.org/10.1007/s11010-012-1507-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23124897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23124897"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yan Zhu, Yan Lei, Baochen Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "INMAP overexpression inhibits cell proliferation, induces genomic instability and functions through p53/p21 pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0115704"}], "href": "https://doi.org/10.1371/journal.pone.0115704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25635878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25635878"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yueqing Wang, Qun Gu, Keyue Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of INMAP postpones mitotic exit and induces apoptosis by disabling the formation of mitotic spindle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.08.002"}], "href": "https://doi.org/10.1016/j.bbrc.2019.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31405563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31405563"}]}]}]}
Synonyms	HLD8, INMAP, RPC2, C128
Proteins	RPC2_HUMAN
NCBI Gene ID	55703
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

POLR3B has 6,167 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for POLR3B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

POLR3B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by POLR3B gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of POLR3B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of POLR3B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of POLR3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of POLR3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of POLR3B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of POLR3B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of POLR3B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of POLR3B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of POLR3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of POLR3B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with POLR3B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with POLR3B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of POLR3B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of POLR3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of POLR3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with POLR3B gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of POLR3B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing POLR3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing POLR3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing POLR3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing POLR3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with POLR3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with POLR3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with POLR3B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with POLR3B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with POLR3B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of POLR3B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving POLR3B gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving POLR3B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with POLR3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with POLR3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with POLR3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with POLR3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with POLR3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with POLR3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at POLR3B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of POLR3B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of POLR3B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing POLR3B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.