{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings have revealed that POLR3C, which encodes a core subunit of RNA polymerase III, plays a critical role in innate antiviral immunity. In one study, children who were heterozygous for rare missense mutations in POLR3C (as well as in POLR3A) exhibited severe varicella zoster virus (VZV) infection with defective interferon induction and impaired viral control. Notably, replacement with the wild‐type allele restored interferon responses, highlighting the importance of POLR3C in recognizing viral DNA and triggering immune defenses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nUnderstanding the broader functions of RNA polymerase III further illuminates the role of POLR3C within this essential enzyme complex. Structural and biochemical studies of other Pol III subunits have demonstrated that the enzyme is organized into distinct subcomplexes that facilitate promoter-specific transcription initiation and possess intrinsic enzymatic activities such as ATP-dependent DNA unwinding. Although these works focused primarily on subunits like hRPC62, hRPC39, and hRPC32, they underscore the coordinated architecture of Pol III in which POLR3C, as one of its core components, is expected to contribute to the accurate transcription of small, untranslated RNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nIn addition, integrative genomic analyses in neuropsychiatric research have begun to prioritize genes involved in basic transcriptional regulation for their contributions to complex disorders. While studies on antidepressant response and attention deficit hyperactivity disorder (ADHD) have not directly delineated POLR3C’s function, the identification of transcriptional modules that include RNA polymerase III subunits suggests that variations in POLR3C may influence neuronal gene expression and thereby contribute to disease heterogeneity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Benson Ogunjimi, Shen-Ying Zhang, Katrine B Sørensen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2010.08.011"}], "href": "https://doi.org/10.1016/j.biopsych.2010.08.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20970119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20970119"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Benjamin Harich, Monique van der Voet, Marieke Klein, et al. 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