POLR3G Gene

HGNC Family	RNA polymerase subunits (POLR)
Name	polymerase (RNA) III (DNA directed) polypeptide G (32kD)
Description	Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPOLR3G, a subunit of RNA polymerase III, plays a crucial role in maintaining stem cell identity. In undifferentiated human embryonic and induced pluripotent stem cells, high POLR3G expression is associated with sustained pluripotency, with its downregulation triggering differentiation into all three germ layers. Transcriptome analyses indicate that POLR3G supports the expression of specific subsets of protein‐coding and noncoding RNAs, including small RNAs and factors involved in RNA splicing, and is itself regulated by key pluripotency transcription factors such as OCT4 and NANOG as well as the Erk1/2 signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer contexts, POLR3G contributes to oncogenic processes by maintaining a transcriptional program that favors cancer stemness and proliferation. In prostate cancer, depletion of POLR3G leads to proliferative arrest and promotes differentiation, whereas in breast, lung, and bladder cancers its elevated expression correlates with tumorigenesis, metastasis, and chemoresistance. Specifically, POLR3G modulates the expression of small noncoding RNAs (e.g., those derived from Alu elements and snaR-A) and influences key signaling cascades such as the PI3K/AKT pathway, thereby driving epithelial–mesenchymal transition and adverse patient outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in stem cell maintenance and cancer, POLR3G, as an integral component of RNA polymerase III, is engaged in innate immune responses and genomic stability. The polymerase complex participates in the detection of cytosolic DNA from intracellular pathogens and activates antiviral mechanisms, while also contributing to the repair of DNA double‐strand breaks by synthesizing RNA intermediates that protect 3′ single‐stranded DNA overhangs during homologous recombination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Raymond Ching-Bong Wong, Sara Pollan, Helen Fong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.714"}], "href": "https://doi.org/10.1002/stem.714"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21898682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21898682"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Riikka J Lund, Nelly Rahkonen, Maia Malonzo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Reports (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stemcr.2017.04.016"}], "href": "https://doi.org/10.1016/j.stemcr.2017.04.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28494942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28494942"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "John L Petrie, Caroline Swan, Richard M Ingram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects on prostate cancer cells of targeting RNA polymerase III."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz128"}], "href": "https://doi.org/10.1093/nar/gkz128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30820548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30820548"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kevin Van Bortle, David P Marciano, Qing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-30323-6"}], "href": "https://doi.org/10.1038/s41467-022-30323-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35637192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35637192"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hualin Chen, Lin Ma, Wenjie Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202301095R"}], "href": "https://doi.org/10.1096/fj.202301095R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37933949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37933949"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lai Wei, Vedran Pavlovic, Aruna T Bansal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Viral Hepat (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jvh.13107"}], "href": "https://doi.org/10.1111/jvh.13107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30972912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30972912"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sijie Liu, Yu Hua, Jingna Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2021.01.048"}], "href": "https://doi.org/10.1016/j.cell.2021.01.048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33626331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33626331"}]}]}]}
Synonyms	RPC7, RPC32
Proteins	RPC7_HUMAN
NCBI Gene ID	10622
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

POLR3G has 6,489 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for POLR3G from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

POLR3G Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by POLR3G gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of POLR3G gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of POLR3G gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of POLR3G gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of POLR3G gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of POLR3G gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of POLR3G gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of POLR3G gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of POLR3G gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of POLR3G gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of POLR3G gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of POLR3G gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of POLR3G gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with POLR3G protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with POLR3G gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of POLR3G gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of POLR3G gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of POLR3G gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of POLR3G gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing POLR3G protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of POLR3G gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing POLR3G protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing POLR3G protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing POLR3G protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with POLR3G protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with POLR3G protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of POLR3G gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with POLR3G gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with POLR3G gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with POLR3G gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with POLR3G gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of POLR3G protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by POLR3G gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for POLR3G protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with POLR3G gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with POLR3G gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with POLR3G gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with POLR3G gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at POLR3G gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of POLR3G gene from the ENCODE Transcription Factor Binding Site Profiles dataset.