| Name | porcupine homolog (Drosophila) |
| Description | This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPORCN is an integral membrane‐bound O‐acyltransferase that catalyzes the essential palmitoleoylation of Wnt proteins, a post‐translational modification required for their proper secretion and subsequent signaling in development and adult tissue homeostasis. Structural and biochemical reconstitution studies have unveiled that PORCN selectively recognizes a conserved hairpin region in Wnt ligands and mediates the transfer of an unsaturated fatty acid to a specific serine residue—an event that is effectively blocked by small‐molecule inhibitors such as LGK974. This mechanism provides the molecular basis for modulating Wnt activity and has been detailed through in vitro acylation assays, substrate specificity analyses, and cryo‐electron microscopy structures."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations in PORCN underlie a spectrum of developmental disorders, most notably focal dermal hypoplasia (Goltz‐Gorlin syndrome), which is characterized by defects in skin, skeletal, dental, ocular, and other ecto‐mesodermal tissues. A wide array of PORCN mutations—including nonsense, missense, frameshift, splice‐site mutations, and large deletions—have been identified, often presenting with mosaicism or skewed X‐inactivation that contributes to the variable expressivity and sporadic nature of the disease. Moreover, novel clinical manifestations such as non‐syndromic anophthalmia/microphthalmia have also been reported in association with PORCN alterations, broadening the developmental phenotypes linked to dysfunctional Wnt secretion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "21"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various malignancies—including lung, colorectal, pancreatic, head and neck, renal, and oral cancers—PORCN has emerged as a critical therapeutic target due to its role in driving oncogenic Wnt signaling. Overexpression or inappropriate activation of this enzyme promotes tumorigenesis, while pharmacologic inhibition of PORCN attenuates Wnt‐dependent transcriptional programs, reduces cell proliferation, and synergizes with inhibitors of other signaling pathways such as PI3K/mTOR. These findings highlight the promise of PORCN inhibitors for cancer treatment and further suggest that modulation of PORCN function may underlie disease processes in other settings, such as neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_fs", "start_ref": "24", "end_ref": "29"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoling Wang, V Reid Sutton, J Omar Peraza-Llanes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng2057"}], "href": "https://doi.org/10.1038/ng2057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17546030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17546030"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Karl-Heinz Grzeschik, Dorothea Bornholdt, Frank Oeffner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng2052"}], "href": "https://doi.org/10.1038/ng2052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17546031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17546031"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Miranda, L M Galli, M Enriquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the WNT1 residues required for palmitoylation by Porcupine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2014.11.016"}], "href": "https://doi.org/10.1016/j.febslet.2014.11.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25451226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25451226"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Naoko Masumoto, Thomas Lanyon-Hogg, Ursula R Rodgers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Membrane bound O-acyltransferases and their inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Soc Trans (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BST20150018"}], "href": "https://doi.org/10.1042/BST20150018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25849925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25849925"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "B Madan, Z Ke, N Harmston, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt addiction of genetically defined cancers reversed by PORCN inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2015.280"}], "href": "https://doi.org/10.1038/onc.2015.280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26257057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26257057"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "James J Asciolla, Matthew M Miele, Ronald C Hendrickson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C117.800136"}], "href": "https://doi.org/10.1074/jbc.C117.800136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28655768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28655768"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chul-Jin Lee, Mitra S Rana, Chanhyung Bae, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "In vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " reconstitution of Wnt acylation reveals structural determinants of substrate recognition by the acyltransferase human Porcupine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.005746"}], "href": "https://doi.org/10.1074/jbc.RA118.005746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30420431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30420431"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yang Liu, Xiaofeng Qi, Linda Donnelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanisms and inhibition of Porcupine-mediated Wnt acylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-022-04952-2"}], "href": "https://doi.org/10.1038/s41586-022-04952-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35831507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35831507"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "May-Britt Harmsen, Silvia Azzarello-Burri, M Mar García González, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Goltz-Gorlin (focal dermal hypoplasia) and the microphthalmia with linear skin defects (MLS) syndrome: no evidence of genetic overlap."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2009.40"}], "href": "https://doi.org/10.1038/ejhg.2009.40"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19277062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19277062"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Dorothea Bornholdt, Frank Oeffner, Arne König, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PORCN mutations in focal dermal hypoplasia: coping with lethality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20992"}], "href": "https://doi.org/10.1002/humu.20992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19309688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19309688"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "S M Maas, M P Lombardi, A J van Essen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotype and genotype in 17 patients with Goltz-Gorlin syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2009.068403"}], "href": "https://doi.org/10.1136/jmg.2009.068403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19586929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19586929"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "G Froyen, K Govaerts, H Van Esch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel PORCN mutations in focal dermal hypoplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1399-0004.2009.01248.x"}], "href": "https://doi.org/10.1111/j.1399-0004.2009.01248.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19863546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19863546"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Priscilla H Fernandes, Shu Wen, Vernon Reid Sutton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PORCN mutations and variants identified in patients with focal dermal hypoplasia through diagnostic gene sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2010.0089"}], "href": "https://doi.org/10.1089/gtmb.2010.0089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20854095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20854095"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Maria Paola Lombardi, Saskia Bulk, Jacopo Celli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation update for the PORCN gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21505"}], "href": "https://doi.org/10.1002/humu.21505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21472892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21472892"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Gen Nakanishi, Kosei Hasegawa, Takashi Oono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel and recurrent PORCN gene mutations in almost unilateral and typical focal dermal hypoplasia patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Dermatol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1684/ejd.2012.1911"}], "href": "https://doi.org/10.1684/ejd.2012.1911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23399492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23399492"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Livia Garavelli, Graziella Simonte, Simonetta Rosato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Focal dermal hypoplasia (Goltz-Gorlin syndrome): a new case with a novel variant in the PORCN gene (c.1250T>C:p.F417S) and unusual spinal anomaly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.35964"}], "href": "https://doi.org/10.1002/ajmg.a.35964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23696273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23696273"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Marielle P Young, Briana L Sawyer, M Elizabeth Hartnett "}, {"type": "b", "children": [{"type": "t", "text": "Ophthalmologic findings in an 18-month-old boy with focal dermal hypoplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J AAPOS (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaapos.2013.11.015"}], "href": "https://doi.org/10.1016/j.jaapos.2013.11.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24698628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24698628"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Paul D Brady, Hilde Van Esch, Nathalie Fieremans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the phenotypic spectrum of PORCN variants in two males with syndromic microphthalmia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2014.135"}], "href": "https://doi.org/10.1038/ejhg.2014.135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25026905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25026905"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Anna Wawrocka, Joanna Walczak-Sztulpa, Marta Pawlak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-syndromic anophthalmia/microphthalmia can be caused by a PORCN variant inherited in X-linked recessive manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61938"}], "href": "https://doi.org/10.1002/ajmg.a.61938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33111437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33111437"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Laura Castilla-Vallmanya, Semra Gürsoy, Özlem Giray-Bozkaya, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "De Novo PORCN"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ZIC2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Mutations in a Highly Consanguineous Family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22041549"}], "href": "https://doi.org/10.3390/ijms22041549"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33557041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33557041"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Rasha Moheb Elhossini, Mohamed S Abdel-Hamid, Engy Ashaat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two new patients with focal dermal hypoplasia: A novel PORCN variant and insights on the diagnostic considerations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Congenit Anom (Kyoto) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cga.12457"}], "href": "https://doi.org/10.1111/cga.12457"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34962003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34962003"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Z Chen, J Li, Q S Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of PPN/MG61 attenuates Wnt/beta-catenin signaling pathway and induces apoptosis in human lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1211006"}], "href": "https://doi.org/10.1038/sj.onc.1211006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18193088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18193088"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Tracy M Covey, Simran Kaur, Tina Tan Ong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0034532"}], "href": "https://doi.org/10.1371/journal.pone.0034532"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22509316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22509316"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Robert Kleszcz, Anna Szymańska, Violetta Krajka-Kuźniak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-019-00440-4"}], "href": "https://doi.org/10.1007/s13402-019-00440-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31089983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31089983"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Zheng Zhong, Sugunavathi Sepramaniam, Xin Hui Chew, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-0908-1"}], "href": "https://doi.org/10.1038/s41388-019-0908-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31391551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31391551"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jianyi Li, Guangzhen Wu, Yingkun Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/2527643"}], "href": "https://doi.org/10.1155/2020/2527643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32104684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32104684"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Rowida Mohamed, Catherine Kennedy, William G Willmore "}, {"type": "b", "children": [{"type": "t", "text": "Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2021.110047"}], "href": "https://doi.org/10.1016/j.cellsig.2021.110047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34015469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34015469"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jesse R Macyczko, Na Wang, Jing Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-022-03065-1"}], "href": "https://doi.org/10.1007/s12035-022-03065-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36215026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36215026"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Daniel Peña-Oyarzún, Tania Flores, Vicente A Torres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of PORCN Blocks Wnt Signaling to Attenuate Progression of Oral Carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-23-0318"}], "href": "https://doi.org/10.1158/1078-0432.CCR-23-0318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37812478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37812478"}]}]}]}
|
| Synonyms | MG61, PPN, DHOF, FODH |
| Proteins | PORCN_HUMAN |
| NCBI Gene ID | 64840 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
PORCN has 6,275 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.
Click the + buttons to view associations for PORCN from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PORCN gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of PORCN gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PORCN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PORCN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of PORCN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PORCN gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of PORCN gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PORCN gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PORCN gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PORCN gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PORCN gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene Mutation Profiles | cell lines with PORCN gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with PORCN protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with PORCN gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PORCN gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of PORCN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PORCN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations | phenotypes associated with PORCN gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with PORCN gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PORCN gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PORCN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing PORCN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing PORCN protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing PORCN protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with PORCN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PORCN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PORCN gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with PORCN gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with PORCN gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by PORCN gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving PORCN gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving PORCN gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PORCN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PORCN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with PORCN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with PORCN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PORCN gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PORCN gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of PORCN gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing PORCN from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of PORCN gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with PORCN gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PORCN from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of PORCN gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PORCN gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PORCN gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PORCN gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PORCN gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PORCN gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving PORCN gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving PORCN gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving PORCN gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing PORCN protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing PORCN protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing PORCN protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by PORCN gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by PORCN gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by PORCN gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of PORCN gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PORCN gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PORCN gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PORCN gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of PORCN gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of PORCN gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of PORCN gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of PORCN gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of PORCN protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PORCN gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with PORCN gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for PORCN from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for PORCN protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of PORCN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of PORCN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PORCN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving PORCN protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PORCN gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of PORCN gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PORCN gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of PORCN gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of PORCN gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PORCN protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by PORCN gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting PORCN gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PORCN gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by PORCN gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MW Enzyme Metabolite Associations | interacting metabolites for PORCN protein from the MW Gene Metabolite Associations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of PORCN gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with PORCN gene from the curated OMIM Gene-Disease Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for PORCN from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PORCN gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of PORCN gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving PORCN protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving PORCN protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving PORCN protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving PORCN protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of PORCN gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of PORCN gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PORCN gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PORCN gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PORCN gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PORCN gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| SynGO Synaptic Gene Annotations | synaptic terms associated with PORCN gene from the SynGO Synaptic Gene Annotations dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of PORCN gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of PORCN gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PORCN gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PORCN gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of PORCN protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PORCN protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of PORCN protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PORCN protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PORCN protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PORCN protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving PORCN protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving PORCN protein from the WikiPathways Pathways 2024 dataset. | |
