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In diverse experimental settings—including chemotherapy‐induced tissue responses, innate immune activation by cytosolic signals, and developmental differentiation—caspase‐3 not only executes cell demolition but also processes proteins like POTED to promote membrane permeabilization. This dual capacity has been implicated in the regulation of cell disassembly, synaptic remodeling, and even modulation of differentiation and survival pathways, underscoring its importance in maintaining tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its immediate role in cell‐intrinsic death pathways, the caspase‐mediated activation of POTED is emerging as a central event in a variety of pathological contexts. 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