POU2F3 Gene

HGNC Family	Homeoboxes
Name	POU class 2 homeobox 3
Description	This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn small cell lung cancer (SCLC) and related neuroendocrine malignancies, POU2F3 functions as a master regulator of a distinct tuft cell‐like lineage. Studies have shown that POU2F3 is exclusively expressed in a subset of SCLC that lacks classic neuroendocrine markers and instead displays a chemosensory tuft cell–like phenotype. Functional genomic screens and chromatin and RNA profiling have established its key role in driving this unique transcriptional program—with coactivators such as OCA‐T1 (POU2AF2) further enhancing its activity—and have underpinned its potential as a therapeutic vulnerability. In addition, immunohistochemical analyses have allowed tumors to be classified according to the expression of POU2F3 (as opposed to ASCL1 or NEUROD1), and similar expression patterns have been identified in certain thymic squamous cell carcinomas. Moreover, targeting the epigenetic and chromatin remodeling machinery that sustains the POU2F3 gene network, such as mSWI/SNF complexes, has been demonstrated to attenuate tumor proliferation in this molecular subtype."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in oncogenesis, POU2F3 is critical for the differentiation of specialized chemosensory cells in normal tissues. For example, in the main olfactory epithelium, POU2F3 (also referred to as Skn-1a or OCT-11 in some studies) contributes to the development and function of microvillous cells, which are involved in environmental chemosensation. Furthermore, integrated network analyses in locally advanced rectal cancer have proposed a protective role for POU2F3—suggesting that beyond its lineage‐defining function in neoplasia, it may also serve as an attractive target for therapeutic intervention in other malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn epithelial tissues such as the skin and cervix, where the POU2F3 protein is often discussed interchangeably with Skn-1a/Oct-11, it plays a pivotal role in maintaining a balance between proliferation and differentiation. POU2F3 regulates the expression of key markers of terminal differentiation—including cytokeratins and proteins such as SPRR2A—as well as modulating matrix metalloproteinase activity that is critical for tissue homeostasis. Loss of POU2F3 expression, which in several cases is mediated by promoter hypermethylation, has been associated with tumor progression in cervical cancer. Additionally, POU2F3 has been implicated in enhancing HPV16 DNA replication via binding to novel sites near the viral origin, and its finely tuned nuclear localization and protein–protein interactions are essential for its regulatory functions in keratinocytes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "19"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu-Han Huang, Olaf Klingbeil, Xue-Yan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.314815.118"}], "href": "https://doi.org/10.1101/gad.314815.118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29945888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29945888"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marina K Baine, Min-Shu Hsieh, W Victoria Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thorac Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jtho.2020.09.009"}], "href": "https://doi.org/10.1016/j.jtho.2020.09.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33011388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33011388"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yosuke Yamada, Akihiko Sugimoto, Masahito Hoki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POU2F3 beyond thymic carcinomas: expression across the spectrum of thymomas hints to medullary differentiation in type A thymoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virchows Arch (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00428-021-03229-9"}], "href": "https://doi.org/10.1007/s00428-021-03229-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34988657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34988657"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoli S Wu, Xue-Yan He, Jonathan J Ipsaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-022-04842-7"}], "href": "https://doi.org/10.1038/s41586-022-04842-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35576971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35576971"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marina K Baine, Christopher A Febres-Aldana, Jason C Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thorac Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jtho.2022.06.004"}], "href": "https://doi.org/10.1016/j.jtho.2022.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35760287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35760287"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Aileen Patricia Szczepanski, Natsumi Tsuboyama, Jun Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POU2AF2/C11orf53 functions as a coactivator of POU2F3 by maintaining chromatin accessibility and enhancer activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.abq2403"}], "href": "https://doi.org/10.1126/sciadv.abq2403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36197978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36197978"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu-Qing Chen, Ling-Ling Gao, Ling-Cong Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The predictive value of YAP-1 and POU2F3 for the efficacy of immuno-chemotherapy in extensive-stage SCLC patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Treat Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ctarc.2023.100684"}], "href": "https://doi.org/10.1016/j.ctarc.2023.100684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36716535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36716535"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Naoe Jimbo, Chiho Ohbayashi, Maiko Takeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "POU2F3-Expressing Small Cell Lung Carcinoma and Large Cell Neuroendocrine Carcinoma Show Morphologic and Phenotypic Overlap."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000002145"}], "href": "https://doi.org/10.1097/PAS.0000000000002145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37904277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37904277"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Leslie Duplaquet, Kevin So, Alexander W Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2024.06.012"}], "href": "https://doi.org/10.1016/j.ccell.2024.06.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39029464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39029464"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tatsuya Yamaguchi, Junpei Yamashita, Makoto Ohmoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2202-15-13"}], "href": "https://doi.org/10.1186/1471-2202-15-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24428937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24428937"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Edoardo D'Angelo, Chiara Pastrello, Andrea Biccari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An integrated multiomics analysis of rectal cancer patients identified POU2F3 as a putative druggable target and entinostat as a cytotoxic enhancer of 5-fluorouracil."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.34478"}], "href": "https://doi.org/10.1002/ijc.34478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36815540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36815540"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Adriana Cabral, David F Fischer, Wilbert P Vermeij, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M300508200"}], "href": "https://doi.org/10.1074/jbc.M300508200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12624109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12624109"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yutaka Enomoto, Kikuko Enomoto, Tadaichi Kitamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Keratinocyte-specific POU transcription factor hSkn-1a represses the growth of cervical cancer cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207653"}], "href": "https://doi.org/10.1038/sj.onc.1207653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15077167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15077167"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Z Zhang, P C Huettner, L Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209530"}], "href": "https://doi.org/10.1038/sj.onc.1209530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16607278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16607278"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Inken M Beck, Matthias Müller, Rolf Mentlein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.jid.5700674"}], "href": "https://doi.org/10.1038/sj.jid.5700674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17195013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17195013"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Iwao Kukimoto, Seiichiro Mori, Hidetaka Sato, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.09.102"}], "href": "https://doi.org/10.1016/j.bbrc.2010.09.102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20888799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20888799"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ryuta Moritsugu, Katsuto Tamai, Hajime Nakano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of the nuclear localization signal of the POU transcription factor Skn‑1a in epidermal keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2014.1803"}], "href": "https://doi.org/10.3892/ijmm.2014.1803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24954220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24954220"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Christine Neumann, Mei Bigliardi-Qi, Christian Widmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2014.370"}], "href": "https://doi.org/10.1038/jid.2014.370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25178105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25178105"}]}]}]}
Synonyms	OCT11, PLA-1, PLA1, SKN-1A, OTF-11, EPOC-1, OCT-11
Proteins	PO2F3_HUMAN
NCBI Gene ID	25833
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

POU2F3 has 5,805 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for POU2F3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

POU2F3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by POU2F3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of POU2F3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of POU2F3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of POU2F3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of POU2F3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of POU2F3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of POU2F3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of POU2F3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of POU2F3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of POU2F3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of POU2F3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of POU2F3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with POU2F3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of POU2F3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of POU2F3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of POU2F3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of POU2F3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of POU2F3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing POU2F3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing POU2F3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing POU2F3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with POU2F3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with POU2F3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of POU2F3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with POU2F3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with POU2F3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by POU2F3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with POU2F3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with POU2F3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with POU2F3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with POU2F3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with POU2F3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with POU2F3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at POU2F3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of POU2F3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of POU2F3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing POU2F3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with POU2F3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with POU2F3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of POU2F3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.