PPIAL4E Gene

Name peptidylprolyl isomerase A (cyclophilin A)-like 4E
Description Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPPIAL4E is a member of the peptidyl‐prolyl cis–trans isomerase family, a group known for modulating protein folding and cellular signaling. In a study evaluating the role of ligand cyclophilin A (CypA) and its receptor CD147 in tongue squamous cell carcinoma (TSCC), associations with hypoxia, angiogenesis, lymph node metastasis, and overall prognosis were highlighted."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the study did not directly evaluate PPIAL4E, insights from related PPI family proteins suggest that PPIAL4E may similarly influence the cellular microenvironment.\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBy analogy with CypA, which activates CD147-mediated pathways under hypoxic and angiogenic conditions contributing to tumor progression, PPIAL4E is postulated to participate in maintaining protein homeostasis and modulating signaling events that affect tumor cell survival and metastasis. This inferred role implies that PPIAL4E could be involved in fine-tuning responses to cellular stress and possibly play a part in the regulatory networks driving TSCC progression. Further targeted studies are needed to delineate the exact contribution of PPIAL4E in these processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Congfa Huang, Zhijun Sun, Yan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2559.2011.04130.x"}], "href": "https://doi.org/10.1111/j.1365-2559.2011.04130.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22320715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22320715"}]}]}]}
Synonyms COAS2, PPIAL4F
NCBI Gene ID 730262
API
Download Associations
Predicted Functions View PPIAL4E's ARCHS4 Predicted Functions.
Co-expressed Genes View PPIAL4E's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PPIAL4E's ARCHS4 Predicted Functions.

Functional Associations

PPIAL4E has 847 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.

Click the + buttons to view associations for PPIAL4E from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PPIAL4E gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of PPIAL4E gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of PPIAL4E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with PPIAL4E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of PPIAL4E gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with PPIAL4E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPIAL4E gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of PPIAL4E gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with PPIAL4E gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GO Biological Process Annotations 2023 biological processes involving PPIAL4E gene from the curated GO Biological Process Annotations 2023 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by PPIAL4E gene from the curated GO Molecular Function Annotations 2023 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of PPIAL4E gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
HPM Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of PPIAL4E protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of PPIAL4E gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of PPIAL4E gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEGG Pathways 2026 pathways involving PPIAL4E protein from the KEGG Pathways 2026 dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of PPIAL4E gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of PPIAL4E gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of PPIAL4E gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of PPIAL4E gene from the RummaGEO Gene Perturbation Signatures dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of PPIAL4E gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of PPIAL4E gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with PPIAL4E protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.