PPP1CB Gene

HGNC Family	Phosphatases
Name	protein phosphatase 1, catalytic subunit, beta isozyme
Description	The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSerine/threonine protein phosphatase 1 (PP1) functions as a central hub for dephosphorylation in eukaryotic cells by assembling with diverse regulatory proteins, and among its catalytic isoforms, PPP1CB (the beta subunit) plays a crucial role in conferring substrate specificity. PPP1CB dynamically associates with a wide array of binding partners via short docking motifs to establish holoenzymes that precisely regulate processes including cell cycle progression, transcription, muscle contraction, and metabolic signaling. (."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPPP1CB is integrally involved in the modulation of the RAS/MAPK signaling cascade. It participates in the dephosphorylation of RAF, a critical step for controlling downstream MAPK activities, and its disruption has been directly linked to human rasopathies. Recurrent missense mutations in PPP1CB (such as p.Pro49Arg and p.Ala56Pro) have been identified in patients presenting with Noonan syndrome–like features with loose anagen hair, and studies have delineated a functional MRAS–SHOC2–PPP1CB complex that regulates both MAPK and PI3K–AKT pathways, contributing to hypertrophic cardiomyopathy and developmental deficits. (."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in RAS signaling, PPP1CB directly regulates several other critical pathways by targeting key phosphorylation events. It dephosphorylates AKT at Thr-450, thereby modulating AKT’s activation and downstream effects on cell survival and differentiation. PPP1CB is also responsible for the dephosphorylation of nucleophosmin (NPM), facilitating chromatin remodeling and DNA repair, and it negatively regulates the activation of interferon regulatory factor 7 (IRF7), thereby attenuating antiviral responses. Moreover, aberrant forms of PPP1CB—including RNA chimeras yielding truncated proteins with reduced phosphatase activity—have been implicated in chronic lymphocytic leukemia and malignant melanoma, emphasizing its importance in cellular homeostasis and tumor suppression. (."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEvidence from cardiovascular and cell adhesion studies further highlights a specialized role for PPP1CB in maintaining tissue integrity. Cardiac-specific deletion of Ppp1cb in experimental models leads to aberrant myofilament phosphorylation, resulting in concentric cardiac remodeling and fibrosis; similarly, in endothelial cells, altered levels of the beta isoform disturb integrin-dependent adhesion and fibrin clot retraction. PPP1CB overexpression has been correlated with enhanced migration and invasion of pancreatic cancer cells, and genetic studies have associated dysregulated PPP1CB expression with variations in bone mineral density, underscoring its impact on both cardiac function and skeletal homeostasis. (."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "18"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its cytoplasmic roles, PPP1CB modulates transcriptional regulation and developmental processes through interactions with nuclear factors. It binds to transcription factors such as HOXA2, facilitating their nuclear export and stability, and influences stress response pathways by dephosphorylating CREB, thereby impacting aging and cellular stress. Collectively, these multifaceted interactions underscore the central importance of PPP1CB in both cytoplasmic signal transduction and the regulation of gene expression. (."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ewald Heroes, Bart Lesage, Janina Görnemann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PP1 binding code: a molecular-lego strategy that governs specificity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2012.08547.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2012.08547.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22360570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22360570"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wolfgang Peti, Angus C Nairn, Rebecca Page "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for protein phosphatase 1 regulation and specificity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2012.08509.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2012.08509.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22284538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22284538"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Karen W Gripp, Kimberly A Aldinger, James T Bennett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37781"}], "href": "https://doi.org/10.1002/ajmg.a.37781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27264673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27264673"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Débora Bertola, Guilherme Yamamoto, Michelle Buscarilli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.38070"}], "href": "https://doi.org/10.1002/ajmg.a.38070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28211982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28211982"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ikumi Umeki, Tetsuya Niihori, Taiki Abe, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddz108"}], "href": "https://doi.org/10.1093/hmg/ddz108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31108500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31108500"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Victoria Huckstadt, Josefina Chinton, Abel Gomez, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Melanoma Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CMR.0b013e328346b715"}], "href": "https://doi.org/10.1097/CMR.0b013e328346b715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21566537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21566537"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Thirunavukkarasu Velusamy, Nallasivam Palanisamy, Shanker Kalyana-Sundaram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1214326110"}], "href": "https://doi.org/10.1073/pnas.1214326110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23382248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23382248"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ling Wang, Juan Zhao, Junping Ren, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Protein Phosphatase 1 Beta is Modulated by Chronic Hypoxia and Involved in the Angiogenic Endothelial Cell Migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000430257"}], "href": "https://doi.org/10.1159/000430257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25967976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25967976"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ruijie Liu, Robert N Correll, Jennifer Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2015.08.018"}], "href": "https://doi.org/10.1016/j.yjmcc.2015.08.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26334248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26334248"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ping Zhou, Lin Zhu, Qiongli Fan, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Histones Methyltransferase NSD3 Inhibits Lung Adenocarcinoma Glycolysis Through Interacting with PPP1CB to Decrease STAT3 Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202400381"}], "href": "https://doi.org/10.1002/advs.202400381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39119928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39119928"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Noémie Deneyer, Laure Bridoux, Céline Bombled, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gene Regul Mech (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2019.07.005"}], "href": "https://doi.org/10.1016/j.bbagrm.2019.07.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31323436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31323436"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ling Wang, Lan Zhang, Xiao-Dong Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PP-1β and PP-2Aα modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of αB-crystallin gene and p300-p53 signaling axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.13458"}], "href": "https://doi.org/10.1111/acel.13458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34425033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34425033"}]}]}]}
Synonyms	PP1BETA, PP1B, PPP1CD, NSLH2, HEL-S-80P, PP-1B
Proteins	PP1B_HUMAN
NCBI Gene ID	5500
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PPP1CB has 10,601 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 137 datasets.

Click the + buttons to view associations for PPP1CB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PPP1CB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PPP1CB gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1CB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1CB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PPP1CB gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PPP1CB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PPP1CB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1CB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP1CB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP1CB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PPP1CB gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP1CB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP1CB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PPP1CB protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PPP1CB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP1CB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PPP1CB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PPP1CB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PPP1CB gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PPP1CB gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PPP1CB protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPP1CB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PPP1CB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PPP1CB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PPP1CB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PPP1CB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PPP1CB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PPP1CB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PPP1CB protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP1CB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PPP1CB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PPP1CB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PPP1CB gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PPP1CB gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DGIdb Drug Targets 2026	interacting drugs for PPP1CB protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PPP1CB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PPP1CB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PPP1CB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PPP1CB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PPP1CB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PPP1CB gene from the ENCODE Histone Modification Site Profiles dataset.