PPP1R14B Gene

HGNC Family	Protein phosphatase 1 regulatory subunits (PPP1R)
Name	protein phosphatase 1, regulatory (inhibitor) subunit 14B
Description	Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in innate immune response. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPPP1R14B, also known as PHI‐1, is a phosphorylation‐dependent inhibitor of protein phosphatase 1 (PP1) that modulates the enzyme’s substrate specificity and activity in various cellular contexts. Its regulatory potency, which is dramatically enhanced upon phosphorylation, has been implicated in diverse physiological processes such as smooth muscle contraction, vascular function, and cell migration. Notably, PPP1R14B concentrates at the cell membrane and at the trailing edge of migrating cells—where it facilitates proper retraction during movement—and plays a role in controlling the stability of signaling molecules including Raf‑1, thereby influencing downstream cascades like the MEK–ERK pathway and overall cell survival signals."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn multiple cancer types—including triple‐negative breast cancer, cervical and endometrial cancers, kidney renal clear cell carcinoma, and hepatocellular carcinoma—PPP1R14B is aberrantly upregulated and functions as an oncogene. Its overexpression supports tumor progression by stabilizing and sustaining the phosphorylation of key oncoproteins (such as stathmin 1 and RPS6KA1) and by modulating critical signaling pathways including AKT, NF‑κB, and pathways that regulate microtubule stability. Moreover, regulation of its protein levels via the ubiquitin–proteasome system further underscores its contribution to enhanced cell proliferation, migration, invasion, and chemoresistance, making PPP1R14B a promising prognostic biomarker and potential therapeutic target in these malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Eto, A Karginov, D L Brautigan "}, {"type": "b", "children": [{"type": "t", "text": "A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (1999)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi992030o"}], "href": "https://doi.org/10.1021/bi992030o"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10606530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10606530"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nikolaos A Tountas, David L Brautigan "}, {"type": "b", "children": [{"type": "t", "text": "Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01506"}], "href": "https://doi.org/10.1242/jcs.01506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15522888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15522888"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nikolaos A Tountas, James W Mandell, Allen D Everett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-004-0642-8"}], "href": "https://doi.org/10.1007/s00418-004-0642-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15083373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15083373"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jason A Kirkbride, Garbo Young Nilsson, Jee In Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom13121741"}], "href": "https://doi.org/10.3390/biom13121741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38136612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38136612"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Li Liao, Yin-Ling Zhang, Ling Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-22-2709"}], "href": "https://doi.org/10.1158/0008-5472.CAN-22-2709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36484700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36484700"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nan Xiang, Tao Chen, Xiaoli Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vitro assessment of roles of PPP1R14B in cervical and endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2022.101845"}], "href": "https://doi.org/10.1016/j.tice.2022.101845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35679681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35679681"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lang Cheng, Junhao Mi, Jiange Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated PPP1R14B is connected to cancer progression and immune infiltration in kidney renal clear cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-023-03228-z"}], "href": "https://doi.org/10.1007/s12094-023-03228-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37261660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37261660"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nana Zhou, Chaoqin Guo, Jingyang Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PPP1R14B-mediated phosphorylation enhances protein stability of RPS6KA1 to promote hepatocellular carcinoma tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2024.119840"}], "href": "https://doi.org/10.1016/j.bbamcr.2024.119840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39216602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39216602"}]}]}]}
Synonyms	PHI-1, PLCB3N, SOM172, PNG
Proteins	PP14B_HUMAN
NCBI Gene ID	26472
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PPP1R14B has 7,189 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for PPP1R14B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PPP1R14B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1R14B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1R14B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PPP1R14B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PPP1R14B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1R14B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP1R14B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP1R14B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP1R14B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PPP1R14B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP1R14B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PPP1R14B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PPP1R14B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP1R14B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PPP1R14B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PPP1R14B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPP1R14B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PPP1R14B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PPP1R14B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PPP1R14B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP1R14B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PPP1R14B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with PPP1R14B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PPP1R14B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PPP1R14B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PPP1R14B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PPP1R14B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PPP1R14B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PPP1R14B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PPP1R14B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP1R14B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PPP1R14B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PPP1R14B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PPP1R14B gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP1R14B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PPP1R14B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PPP1R14B from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PPP1R14B gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of PPP1R14B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of PPP1R14B gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPP1R14B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.