{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA large number of studies have established that apolipoprotein M (apoM) is a central regulator of high‐density lipoprotein (HDL) functionality, acting primarily as a chaperone for sphingosine‑1‑phosphate (S1P). By delivering S1P to its receptors on endothelial cells, apoM‐bound S1P promotes vascular integrity, limits inflammatory responses, and modulates lymphocyte trafficking. In addition, apoM contributes to reverse cholesterol transport and preβ‑HDL formation, exerts antioxidative effects by binding oxidized phospholipids, and has protective roles in conditions such as atherosclerosis, diabetic nephropathy, and sepsis. These functions underscore the pivotal role of the apoM–S1P axis in maintaining cardiovascular and metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of the provided abstracts mention or address the function of PPP1R26. While the body of literature here offers extensive insights into the diverse roles of apoM in lipid metabolism, vascular tone, and immune regulation, it does not furnish any experimental or theoretical data on PPP1R26. Consequently, the biological role of PPP1R26 remains uncharacterized in this collection, highlighting a need for focused investigation to elucidate its function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christina Christoffersen, Hideru Obinata, Sunil B Kumaraswamy, et al. 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