PPP1R7 Gene

HGNC Family	Protein phosphatase 1 regulatory subunits (PPP1R)
Name	protein phosphatase 1, regulatory subunit 7
Description	This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPPP1R7, also known as SDS22, is a highly conserved regulatory subunit of protein phosphatase 1 (PP1) that plays a central role in mitosis. It controls the spatial and temporal dephosphorylation of key substrates such as Aurora B kinase, thereby ensuring proper kinetochore–microtubule interactions and faithful chromosome segregation. PPP1R7 regulates the recruitment and activity of PP1 at the kinetochores, counteracting Aurora B-mediated phosphorylation events that are critical for a robust metaphase–anaphase transition, and its depletion or mislocalization leads to aberrant mitotic progression and segregation defects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in mitosis, PPP1R7 forms part of a ternary complex with PP1 and inhibitor-3 (I3) that exerts substrate-specific regulation of PP1 activity. Structural studies reveal that PPP1R7 is composed of twelve leucine-rich repeats that form a curved scaffold, facilitating interactions with PP1 at sites distinct from those used by other regulators. Moreover, its activity is modulated by post-translational modifications, such as phosphorylation by PLK1, and by regulatory circuits (including miR-134-mediated pathways) that impact downstream ERK/JNK signaling and cortical dynamics during cell division."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central cell cycle functions, PPP1R7 contributes to the maintenance of epithelial integrity and has tumor suppressor properties. Loss or downregulation of PPP1R7 has been linked to disruption of cell polarity, enhanced invasiveness, and oncogenic signaling via deregulation of the AKT pathway. Furthermore, insights into the PP1 interactome in cardiac tissue suggest broader implications of PPP1R7 in disease contexts such as heart failure, highlighting its impact on both proliferation and survival pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Markus Posch, Guennadi A Khoudoli, Sam Swift, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200912046"}], "href": "https://doi.org/10.1083/jcb.200912046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20921135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20921135"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Claudia Wurzenberger, Michael Held, Michael A Lampson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201112112"}], "href": "https://doi.org/10.1083/jcb.201112112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22801782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22801782"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Annika Eiteneuer, Jonas Seiler, Matthias Weith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201489054"}], "href": "https://doi.org/10.15252/embj.201489054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25298395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25298395"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hequan Duan, Chunli Wang, Ming Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.745372"}], "href": "https://doi.org/10.1074/jbc.M116.745372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27557660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27557660"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nelio T L Rodrigues, Sergey Lekomtsev, Silvana Jananji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature14496"}], "href": "https://doi.org/10.1038/nature14496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26168397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26168397"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bart Lesage, Monique Beullens, Leda Pedelini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi7003119"}], "href": "https://doi.org/10.1021/bi7003119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17630778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17630778"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jianmin Wu, Yimin Sun, Pei-Ying Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2016.289"}], "href": "https://doi.org/10.1038/cddis.2016.289"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27685628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27685628"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ewald Heroes, Gerd Van der Hoeven, Meng S Choy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2018.12.002"}], "href": "https://doi.org/10.1016/j.str.2018.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30661852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30661852"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Y Jiang, K L Scott, S-J Kwak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.46"}], "href": "https://doi.org/10.1038/onc.2011.46"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21399659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21399659"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "David Y Chiang, Katherina M Alsina, Eleonora Corradini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.118.034361"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.118.034361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29669786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29669786"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Debasish Paul, Anil Bapu Bargale, Srikanth Rapole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2018.10.009"}], "href": "https://doi.org/10.1016/j.neo.2018.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30500680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30500680"}]}]}]}
Synonyms	SDS22
Proteins	PP1R7_HUMAN
NCBI Gene ID	5510
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PPP1R7 has 6,374 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for PPP1R7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PPP1R7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PPP1R7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1R7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1R7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PPP1R7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PPP1R7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PPP1R7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP1R7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP1R7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP1R7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP1R7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PPP1R7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP1R7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP1R7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PPP1R7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PPP1R7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP1R7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PPP1R7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PPP1R7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PPP1R7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PPP1R7 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPP1R7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PPP1R7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PPP1R7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PPP1R7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PPP1R7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PPP1R7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PPP1R7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PPP1R7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PPP1R7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PPP1R7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PPP1R7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PPP1R7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PPP1R7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PPP1R7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PPP1R7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PPP1R7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PPP1R7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP1R7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PPP1R7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PPP1R7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.