PPP2R5D Gene

HGNC Family	Protein phosphatase 2 regulatory subunits (PPP2R)
Name	protein phosphatase 2, regulatory subunit B', delta
Description	The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPPP2R5D encodes the B56δ regulatory subunit of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase responsible for maintaining proper phosphorylation balance within cells. As an integral component of distinct PP2A holoenzymes, PPP2R5D guides substrate specificity and subcellular localization, thereby modulating pivotal signaling cascades. In mitotic regulation, PP2A complexes containing PPP2R5D help dephosphorylate cell cycle regulators such as Cdc25C, restraining cyclin-dependent kinase 1 activity and ensuring timely exit from mitosis. Furthermore, PPP2R5D-containing holoenzymes also contribute to the regulation of MAPK and Raf1-dependent pathways, underlining its role as a critical mediator of intracellular signal transduction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPathogenic mutations in PPP2R5D disturb its regulatory function and have been increasingly linked to a spectrum of neurodevelopmental and overgrowth disorders. Exome‐sequencing studies have uncovered de novo missense variants that impair the ability of PPP2R5D to bind the scaffold and catalytic subunits of PP2A, leading to aberrant dephosphorylation events and disrupted kinase signaling (notably within the AKT–mTOR axis). Clinically, individuals harboring these mutations exhibit variable degrees of intellectual disability, autism spectrum features, macrocephaly, hypotonia, seizures, and, in some cases, early‐onset, levodopa‐responsive parkinsonism. These findings not only highlight the indispensable role of PPP2R5D in neurodevelopment but also expand its phenotypic spectrum as a genetic determinant in human disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent biochemical and functional genomic studies have further refined our understanding of PPP2R5D regulation. Detailed mapping of its phosphorylation sites has revealed that post‐translational modifications can modulate the affinity of the PP2A holoenzyme for its substrates, thus fine‐tuning catalytic activity. Moreover, innovative strategies to reduce PP2A holoenzyme complexity—by engineering complementary interface mutations or employing CRISPR‐mediated single‐base editing—have underscored how alterations in PPP2R5D compromise substrate recognition and signal fidelity. Intriguingly, PPP2R5D levels can also be perturbed by viral proteins, as exemplified by HIV-1 Vif-mediated degradation of B56 family members, which reinforces its central role in cell cycle regulation and homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Beth A Firulli, Marthe J Howard, Jennifer R McDaid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(03)00425-8"}], "href": "https://doi.org/10.1016/s1097-2765(03"}, {"type": "t", "text": "00425-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14636580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14636580"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Craig M Forester, Jessica Maddox, Justin V Louis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0709879104"}], "href": "https://doi.org/10.1073/pnas.0709879104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18056802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18056802"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Un Young Yu, Jung-Hyuck Ahn "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMB Rep (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5483/bmbrep.2010.43.4.263"}], "href": "https://doi.org/10.5483/bmbrep.2010.43.4.263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20423611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20423611"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Antonio Espert, Pelin Uluocak, Ricardo Nunes Bastos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201406109"}], "href": "https://doi.org/10.1083/jcb.201406109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25246613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25246613"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chey Loveday, Katrina Tatton-Brown, Matthew Clarke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv182"}], "href": "https://doi.org/10.1093/hmg/ddv182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25972378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25972378"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gunnar Houge, Dorien Haesen, Lisenka E L M Vissers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI79860"}], "href": "https://doi.org/10.1172/JCI79860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26168268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26168268"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Linshan Shang, Lindsay B Henderson, Megan T Cho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo missense variants in PPP2R5D are associated with intellectual disability, macrocephaly, hypotonia, and autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-015-0466-9"}], "href": "https://doi.org/10.1007/s10048-015-0466-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26576547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26576547"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Christine Y Kim, Thomas Wirth, Cécile Hubsch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early-Onset Parkinsonism Is a Manifestation of the PPP2R5D p.E200K Mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.25863"}], "href": "https://doi.org/10.1002/ana.25863"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32743835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32743835"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Cinta M Papke, Kali A Smolen, Mark R Swingle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.100313"}], "href": "https://doi.org/10.1016/j.jbc.2021.100313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33482199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33482199"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Priyanka Madaan, Amrit Kaur, Lokesh Saini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PPP2R5D-Related Neurodevelopmental Disorder or Developmental and Epileptic Encephalopathy?: A Novel Phenotypic Description and Review of Published Cases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropediatrics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-0041-1733984"}], "href": "https://doi.org/10.1055/s-0041-1733984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34448180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34448180"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Elisabetta Tabolacci, Maria Grazia Pomponi, Laura Remondini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-Occurrence of Fragile X Syndrome with a Second Genetic Condition: Three Independent Cases of Double Diagnosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes12121909"}], "href": "https://doi.org/10.3390/genes12121909"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34946857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34946857"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Pingping Ning, Kelu Li, Hui Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare missense variants in the PPP2R5D gene associated with Parkinson's disease in the Han Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2022.136564"}], "href": "https://doi.org/10.1016/j.neulet.2022.136564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35257824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35257824"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Nora Oyama, Pieter Vaneynde, Sara Reynhout, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical, neuroimaging and molecular characteristics of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PPP2R5D"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-related neurodevelopmental disorders: an expanded series with functional characterisation and genotype-phenotype analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg-2022-108713"}], "href": "https://doi.org/10.1136/jmg-2022-108713"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36216457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36216457"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ruihong Liu, Yihuan Huang, Chunyi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel nonsense mutation in PPP2R5D is associated with neurodevelopmental disorders and shows incomplete penetrance in a Chinese pedigree."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Neurol Neurosurg (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clineuro.2022.107524"}], "href": "https://doi.org/10.1016/j.clineuro.2022.107524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36403339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36403339"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Parveen Kumar, Prajakta Tathe, Neelam Chaudhary, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PPM1G forms a PPP-type phosphatase holoenzyme with B56δ that maintains adherens junction integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201846965"}], "href": "https://doi.org/10.15252/embr.201846965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31432583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31432583"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chian Ju Jong, Ronald A Merrill, Emily M Wilkerson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A/B'δ holoenzyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.011270"}], "href": "https://doi.org/10.1074/jbc.RA119.011270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32156701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32156701"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kayoko Nagata, Keisuke Shindo, Yusuke Matsui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.04.123"}], "href": "https://doi.org/10.1016/j.bbrc.2020.04.123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32446377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32446377"}]}]}]}
Synonyms	B56D, MRD35, B56delta
Proteins	2A5D_HUMAN
NCBI Gene ID	5528
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PPP2R5D has 5,851 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for PPP2R5D from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PPP2R5D Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP2R5D gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP2R5D gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PPP2R5D gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PPP2R5D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PPP2R5D gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP2R5D gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving PPP2R5D protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP2R5D gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP2R5D gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP2R5D gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP2R5D gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP2R5D gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PPP2R5D protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PPP2R5D gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP2R5D gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PPP2R5D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PPP2R5D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PPP2R5D gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PPP2R5D protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPP2R5D gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PPP2R5D protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PPP2R5D protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PPP2R5D protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PPP2R5D protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PPP2R5D protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PPP2R5D protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP2R5D gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PPP2R5D gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PPP2R5D gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PPP2R5D gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PPP2R5D gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving PPP2R5D gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PPP2R5D gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PPP2R5D gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PPP2R5D gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PPP2R5D gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PPP2R5D gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP2R5D gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PPP2R5D gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PPP2R5D from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.