PPP3CC Gene

HGNC Family	Phosphatases
Name	protein phosphatase 3, catalytic subunit, gamma isozyme
Description	Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPPP3CC encodes the gamma isoform of the catalytic subunit of calcineurin, a calcium/calmodulin‐dependent serine/threonine phosphatase that is pivotal for neuronal signaling and synaptic plasticity. Several genetic association studies have implicated variants in PPP3CC with schizophrenia, supporting a model in which altered calcineurin signaling contributes to the risk and progression of neuropsychiatric disorders. In diverse populations, common single nucleotide polymorphisms in PPP3CC have been linked to the disorder, and blood expression levels of calcineurin A gamma appear to correlate with psychosis severity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn-depth biochemical analyses have demonstrated that, relative to the other calcineurin catalytic isoforms, PPP3CC confers unique substrate specificities that affect the kinetics of dephosphorylation of targets such as transcription factors and signaling proteins. Notably, immunocytochemistry and electron microscopy studies have localized calcineurin A gamma to presynaptic terminals in hippocampal neurons, and RNA interference–mediated knockdown of PPP3CC disrupts synaptic vesicle cycling. Moreover, pharmacogenetic investigations suggest that variations in PPP3CC can influence antidepressant response, potentially via modulation of immune and synaptic plasticity pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in the nervous system, PPP3CC has been implicated in broader cellular functions. In human embryonic stem cells, knockdown of PPP3CC (calcineurin A gamma) perturbs lineage commitment and epithelial–mesenchymal transition by disrupting the NFATc3/SRPX2 axis, highlighting its influence on cell fate decisions. Similarly, in epithelial ovarian cancer, reduced expression of PPP3CC—linked to dysregulation by miR-200c-3p—correlates with altered apoptotic signaling, supporting a potential tumor suppressor function. In addition, mechanistic studies have shown that PPP3CC interacts with proteins such as ITPKC to regulate the IP3–Ca2+ signaling pathway, thereby contributing to intracellular calcium homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough not all investigations have observed a significant association of PPP3CC variants with related disorders—for example, studies in methamphetamine use disorder have not found robust links—the cumulative evidence underscores the diverse roles of PPP3CC. It contributes not only to the fine-tuning of neuronal signaling and synaptic plasticity, which are critical for normal cognitive and affective functions, but also to mechanisms governing cellular differentiation and apoptosis. This multifaceted involvement positions PPP3CC as a key node in intracellular signaling networks with broad implications for neuropsychiatric conditions and beyond."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alan R Sanders, Jubao Duan, Douglas F Levinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Psychiatry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1176/appi.ajp.2007.07101573"}], "href": "https://doi.org/10.1176/appi.ajp.2007.07101573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18198266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18198266"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "David J Gerber, Diana Hall, Tsuyoshi Miyakawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1432927100"}], "href": "https://doi.org/10.1073/pnas.1432927100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12851458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12851458"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiajun Shi, Elliot S Gershon, Chunyu Liu "}, {"type": "b", "children": [{"type": "t", "text": "Genetic associations with schizophrenia: meta-analyses of 12 candidate genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Schizophr Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.schres.2008.06.016"}], "href": "https://doi.org/10.1016/j.schres.2008.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18715757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18715757"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sharon L Eastwood, Philip W J Burnet, Paul J Harrison "}, {"type": "b", "children": [{"type": "t", "text": "Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2004.12.029"}], "href": "https://doi.org/10.1016/j.biopsych.2004.12.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15820226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15820226"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Y L Liu, C S J Fann, C M Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "More evidence supports the association of PPP3CC with schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.mp.4001977"}], "href": "https://doi.org/10.1038/sj.mp.4001977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17339875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17339875"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Flavie Mathieu, Stéphanie Miot, Bruno Etain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between the PPP3CC gene, coding for the calcineurin gamma catalytic subunit, and bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Funct (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1744-9081-4-2"}], "href": "https://doi.org/10.1186/1744-9081-4-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18201382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18201382"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Emilio Sacchetti, Catia Scassellati, Alessandra Minelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 32 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1 genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-14-33"}], "href": "https://doi.org/10.1186/1471-2350-14-33"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23497497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23497497"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chieko Kyogoku, Masaya Yanagi, Kunihiro Nishimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatry Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.psychres.2009.11.003"}], "href": "https://doi.org/10.1016/j.psychres.2009.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20537399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20537399"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Y Kinoshita, T Suzuki, M Ikeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neural Transm (Vienna) (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00702-004-0261-5"}], "href": "https://doi.org/10.1007/s00702-004-0261-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15843870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15843870"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Masahiko Murata, Masahiko Tsunoda, Tomiki Sumiyoshi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcineurin A gamma and B gene expressions in the whole blood in Japanese patients with schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prog Neuropsychopharmacol Biol Psychiatry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pnpbp.2008.01.013"}], "href": "https://doi.org/10.1016/j.pnpbp.2008.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18343007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18343007"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Susann Kilka, Frank Erdmann, Alexander Migdoll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi8019355"}], "href": "https://doi.org/10.1021/bi8019355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19154138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19154138"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zi-Hong He, Yang Hu, Yan-Chun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Appl Physiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00421-010-1558-8"}], "href": "https://doi.org/10.1007/s00421-010-1558-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20593291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20593291"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "C Fabbri, A Marsano, D Albani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tpj.2014.15"}], "href": "https://doi.org/10.1038/tpj.2014.15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24709691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24709691"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hao Chen, Yanwu Zeng, Min Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.30255"}], "href": "https://doi.org/10.1002/jcp.30255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33393109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33393109"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Eleni Anastasiadou, Elena Messina, Tiziana Sanavia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes12091400"}], "href": "https://doi.org/10.3390/genes12091400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34573382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34573382"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Pu Li, Peng Zhang, Ying Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PPP3CC feedback regulates IP3-Ca2+ pathway through preventing ITPKC degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2741/4153"}], "href": "https://doi.org/10.2741/4153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23747857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23747857"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Y Kinoshita, M Ikeda, H Ujike, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann N Y Acad Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1196/annals.1432.021"}], "href": "https://doi.org/10.1196/annals.1432.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18991849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18991849"}]}]}]}
Synonyms	CNA3, CALNA3, PP2BGAMMA
Proteins	PP2BC_HUMAN
NCBI Gene ID	5533
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PPP3CC has 5,885 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 131 datasets.

Click the + buttons to view associations for PPP3CC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PPP3CC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP3CC gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP3CC gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PPP3CC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PPP3CC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PPP3CC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPP3CC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving PPP3CC protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP3CC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP3CC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPP3CC gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PPP3CC gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP3CC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PPP3CC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PPP3CC gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PPP3CC protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PPP3CC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP3CC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PPP3CC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PPP3CC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PPP3CC protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPP3CC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PPP3CC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PPP3CC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PPP3CC protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PPP3CC protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PPP3CC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PPP3CC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPP3CC gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PPP3CC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with PPP3CC gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PPP3CC protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PPP3CC gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PPP3CC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PPP3CC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PPP3CC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PPP3CC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PPP3CC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PPP3CC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PPP3CC gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPP3CC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.