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Furthermore, interactions with other modulators (for example, SIRT1) extend its role in fine‐tuning the DNA damage response."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its critical function in DNA repair, PPP4C is indispensable for ensuring accurate cell division and proper cytoskeletal organization. It dephosphorylates proteins such as NDEL1, thereby modulating Cdk1 activity at the centrosome to control mitotic spindle orientation and centrosome maturation. 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