PPRC1 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	peroxisome proliferator-activated receptor gamma, coactivator-related 1
Description	The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe PGC-1 family of transcriptional coactivators plays a central role in orchestrating cellular energy metabolism by regulating mitochondrial biogenesis and oxidative phosphorylation. Among these coactivators, PPRC1 (also referred to as PRC in many reports) is highlighted as a key inducible factor that partners with nuclear receptors and transcription factors—such as nuclear respiratory factor 1 (NRF-1)—to promote the expression of nuclear-encoded genes essential for respiratory function. Its activity is linked to the modulation of metabolic pathways in tissues with high-energy demands, including striated muscle and liver, thereby influencing systemic functions as well as diseases such as diabetes and heart failure."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, PPRC1 exerts its function by engaging with key transcription factors and coactivators to fine-tune the expression of respiratory genes. Studies have demonstrated that it directly interacts with factors such as NRF-1 and, indirectly, with the multisubunit activator NRF-2 through complexes mediated by host cell factor 1 (HCF-1), thereby ensuring coordinated transcription of nuclear mitochondrial factors. Furthermore, its regulation is closely tied to cellular proliferation signals, as evidenced by experiments showing that silencing PPRC1 disrupts respiratory complex assembly and mitochondrial ATP production while also impairing cell cycle progression. These findings underscore its importance in both the maintenance of mitochondrial structure and the integration of metabolic and growth-related pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical role in mitochondrial biogenesis, PPRC1 functions as a pivotal mediator of cellular stress responses. It is involved in reprogramming gene expression under metabolic stress through crosstalk with pathways like Akt-GSK-3 and c-MYC, thereby contributing to adaptive inflammatory programs and regulating apoptotic and senescence-associated signals. In vascular endothelium, for example, overexpression of PPRC1 has been shown to counteract inflammatory cues and preserve metabolic function under stress conditions. Notably, emerging pan-cancer analyses further suggest that PPRC1 expression correlates with immune cell infiltration, immune checkpoint expression, and tumor cell stemness, highlighting its potential utility as a prognostic biomarker in oncologic settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Brian N Finck, Daniel P Kelly "}, {"type": "b", "children": [{"type": "t", "text": "PGC-1 coactivators: inducible regulators of energy metabolism in health and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI27794"}], "href": "https://doi.org/10.1172/JCI27794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16511594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16511594"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Natalie Gleyzer, Kristel Vercauteren, Richard C Scarpulla "}, {"type": "b", "children": [{"type": "t", "text": "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.4.1354-1366.2005"}], "href": "https://doi.org/10.1128/MCB.25.4.1354-1366.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15684387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15684387"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "U Andersson, R C Scarpulla "}, {"type": "b", "children": [{"type": "t", "text": "Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.21.11.3738-3749.2001"}], "href": "https://doi.org/10.1128/MCB.21.11.3738-3749.2001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11340167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11340167"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kristel Vercauteren, Natalie Gleyzer, Richard C Scarpulla "}, {"type": "b", "children": [{"type": "t", "text": "PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M710150200"}], "href": "https://doi.org/10.1074/jbc.M710150200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18343819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18343819"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kristel Vercauteren, Natalie Gleyzer, Richard C Scarpulla "}, {"type": "b", "children": [{"type": "t", "text": "Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806434200"}], "href": "https://doi.org/10.1074/jbc.M806434200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19036724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19036724"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Frédérique Savagner, Delphine Mirebeau, Caroline Jacques, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2003.09.076"}], "href": "https://doi.org/10.1016/j.bbrc.2003.09.076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14550271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14550271"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mahatsangy Raharijaona, Soazig Le Pennec, Julie Poirier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007964"}], "href": "https://doi.org/10.1371/journal.pone.0007964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19956726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19956726"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Natalie Gleyzer, Richard C Scarpulla "}, {"type": "b", "children": [{"type": "t", "text": "Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.719682"}], "href": "https://doi.org/10.1074/jbc.M116.719682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27789709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27789709"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Natalie Gleyzer, Richard C Scarpulla "}, {"type": "b", "children": [{"type": "t", "text": "Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.426841"}], "href": "https://doi.org/10.1074/jbc.M112.426841"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23364789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23364789"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zhan Chengye, Zhou Daixing, Zhong Qiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.08.015"}], "href": "https://doi.org/10.1016/j.bbrc.2013.08.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23954632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23954632"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xingqiu Ruan, Guoliang Cui, Changyu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicina (Kaunas) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/medicina59040784"}], "href": "https://doi.org/10.3390/medicina59040784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37109742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37109742"}]}]}]}
Synonyms	PRC
Proteins	PPRC1_HUMAN
NCBI Gene ID	23082
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PPRC1 has 7,380 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for PPRC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PPRC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PPRC1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPRC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPRC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PPRC1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PPRC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PPRC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PPRC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PPRC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PPRC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PPRC1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPRC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PPRC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PPRC1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PPRC1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPRC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PPRC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PPRC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PPRC1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PPRC1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPRC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PPRC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PPRC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PPRC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PPRC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PPRC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PPRC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PPRC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PPRC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PPRC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PPRC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PPRC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PPRC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PPRC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PPRC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PPRC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PPRC1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PPRC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PPRC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PPRC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PPRC1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.