PPT2-EGFL8 Gene

Name	PPT2-EGFL8 readthrough (NMD candidate)
Description	This locus represents naturally occurring read-through transcription between the neighboring PPT2 (palmitoyl-protein thioesterase 2) and EGFL8 (EGF-like-domain, multiple 8) genes located in the major histocompatibility complex class III region of chromosome 6. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]
Synonyms	PPT2
NCBI Gene ID	100532746
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PPT2-EGFL8 has 528 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for PPT2-EGFL8 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PPT2-EGFL8 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PPT2-EGFL8 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPT2-EGFL8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPT2-EGFL8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PPT2-EGFL8 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of PPT2-EGFL8 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of PPT2-EGFL8 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PPT2-EGFL8 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	HPA Cell Line Gene Expression Profiles	cell lines with high or low expression of PPT2-EGFL8 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
	HPA Tissue Gene Expression Profiles	tissues with high or low expression of PPT2-EGFL8 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
	HPA Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PPT2-EGFL8 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of PPT2-EGFL8 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of PPT2-EGFL8 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	cell lines with high or low expression of PPT2-EGFL8 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of PPT2-EGFL8 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of PPT2-EGFL8 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.