{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided literature does not mention PRAMEF9, the collective data instead reveal that ATRX is a multifunctional chromatin‐remodeling protein that plays a central role in establishing and maintaining specialized chromatin domains. ATRX acts as an H3.3‐specific chaperone by partnering with DAXX to promote replication‐independent nucleosome assembly at heterochromatic regions—including telomeres, pericentromeric domains, and imprinted loci—thereby ensuring proper deposition of histone marks (e.g., H3K9me3) and the suppression of repetitive elements. Its affinity for variant DNA structures such as G-quadruplexes further underpins chromatin stability during S-phase and transcriptional elongation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its core chromatin‐regulatory functions, ATRX is crucial for proper cellular differentiation and organismal development. In neural progenitors and maturing neurons, ATRX promotes synaptic organization and survival while safeguarding genome integrity; its deficiency leads to replication stress, mitotic defects, and increased apoptosis that are thought to underlie the cognitive deficits, microcephaly, and other phenotypes observed in ATR-X syndrome. Similar requirements for ATRX have been demonstrated in germ cells, forebrain and mesenchymal tissues, where its role in centromere stability and chromosome alignment is essential for normal meiotic progression, limb formation, and endocrine function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, loss or mutation of ATRX is closely linked to genomic instability and tumorigenesis. Disruption of ATRX compromises DNA repair pathways—particularly the resolution of telomeric double-stranded breaks—and diminishes proper telomere cohesion, thereby increasing susceptibility to replication stress and DNA-damaging agents. Such deficiencies have been observed in diverse cancer models, where ATRX loss correlates with an elevated mutation rate and a distinct therapeutic response, highlighting its potential as a target for tailored oncologic therapies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while these abstracts do not address PRAMEF9, they collectively underscore ATRX’s pivotal functions in chromatin remodeling, epigenetic maintenance, developmental gene regulation, and genome integrity. This multifaceted role of ATRX is central to normal development and is disrupted in a number of human disorders and cancers.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rabindranath De La Fuente, Maria M Viveiros, Karen Wigglesworth, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The b1 isoform of protocadherin-gamma (Pcdhgamma) interacts with the microtubule-destabilizing protein SCG10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2004.10.096"}], "href": "https://doi.org/10.1016/j.febslet.2004.10.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15581637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15581637"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nathalie G Bérubé, Marie Mangelsdorf, Magdalena Jagla, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0608056104"}], "href": "https://doi.org/10.1073/pnas.0608056104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17296936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17296936"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Mary R Muers, Jacqueline A Sharpe, David Garrick, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn424"}], "href": "https://doi.org/10.1093/hmg/ddn424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19088125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19088125"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Lauren A Solomon, Jennifer R Li, Nathalie G Bérubé, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0052167"}], "href": "https://doi.org/10.1371/journal.pone.0052167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23284920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23284920"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Renee J Tamming, Jennifer R Siu, Yan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mosaic expression of Atrx in the mouse central nervous system causes memory deficits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Model Mech (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dmm.027482"}], "href": "https://doi.org/10.1242/dmm.027482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28093507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28093507"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Domenico Marano, Salvatore Fioriniello, Francesca Fiorillo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20215371"}], "href": "https://doi.org/10.3390/ijms20215371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31671722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31671722"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Radu Gugustea, Renee J Tamming, Nicole Martin-Kenny, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of ATRX in forebrain excitatory neurons affects hippocampal synaptic plasticity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hippocampus (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hipo.23174"}], "href": "https://doi.org/10.1002/hipo.23174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31713968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31713968"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Lauren A Solomon, Bailey A Russell, L Ashley Watson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddt351"}], "href": "https://doi.org/10.1093/hmg/ddt351"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23892236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23892236"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Dennis Sadic, Katharina Schmidt, Sophia Groh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atrx promotes heterochromatin formation at retrotransposons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201439937"}], "href": "https://doi.org/10.15252/embr.201439937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26012739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26012739"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Carl Koschmann, Anda-Alexandra Calinescu, Felipe J Nunez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.aac8228"}], "href": "https://doi.org/10.1126/scitranslmed.aac8228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26936505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26936505"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Carla Danussi, Promita Bose, Prasanna T Parthasarathy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-03476-6"}], "href": "https://doi.org/10.1038/s41467-018-03476-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29535300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29535300"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Claire C Young, Ryan M Baker, Christopher J Howlett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Gastroenterol Hepatol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jcmgh.2018.09.004"}], "href": "https://doi.org/10.1016/j.jcmgh.2018.09.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30510993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30510993"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Renee J Tamming, Vanessa Dumeaux, Yan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.107838"}], "href": "https://doi.org/10.1016/j.celrep.2020.107838"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32610139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32610139"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Ru-Xuan Tsai, Kuo-Chen Fang, Po-Cheng Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TERRA regulates DNA G-quadruplex formation and ATRX recruitment to chromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac1114"}], "href": "https://doi.org/10.1093/nar/gkac1114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36440760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36440760"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Warren Floyd, Matthew Pierpoint, Chang Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI149310"}], "href": "https://doi.org/10.1172/JCI149310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37200088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37200088"}]}]}]}