PRDM10 Gene

HGNC Family	Zinc fingers
Name	PR domain containing 10
Description	The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nSome broad screening studies in cancers such as undifferentiated pleomorphic sarcoma and investigations into radiation‐associated breast cancer initially did not reveal specific roles for PRDM10. However, these efforts provided an important backdrop for later research that identified PRDM10 as a novel player in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSubsequent studies in soft tissue tumors have demonstrated that PRDM10 functions principally as a transcriptional regulator. In a subset of undifferentiated pleomorphic sarcomas, gene fusions involving PRDM10—most notably CITED2-PRDM10 and MED12-PRDM10—drive a unique gene expression program, including the consistent upregulation of targets such as CADM3. These fusion events appear to serve as critical driver mutations in these neoplasms, and similar genetic alterations have also been observed in superficial CD34‑positive fibroblastic tumors, suggesting that rearrangements involving PRDM10 contribute to mesenchymal tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in fusion‑driven sarcomas, PRDM10 has been shown to play a major part in a familial cancer syndrome resembling Birt-Hogg-Dubé disease. A germline missense mutation (p.Cys677Tyr) in the zinc-finger domain of PRDM10 disrupts its ability to bind a regulatory motif in the promoter of the FLCN gene, leading to marked downregulation of folliculin. This defective transcriptional regulation is associated with a distinctive syndrome characterized by fibrofolliculomas, mucosal lesions, extensive lipomatosis, and an elevated risk for renal cell carcinomas."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, emerging evidence implicates a long noncoding RNA, PRDM10-DT, in the broader regulatory network governed by PRDM10. In human epidermal keratinocytes exposed to ultraviolet-B radiation, PRDM10-DT appears to modulate autophagy by competing for microRNAs that target the autophagy-related gene IRGM. This regulation may influence key cellular processes such as proliferation and migration during the stress response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jakob Hofvander, Johnbosco Tayebwa, Jenny Nilsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent PRDM10 gene fusions in undifferentiated pleomorphic sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-14-2399"}], "href": "https://doi.org/10.1158/1078-0432.CCR-14-2399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25516889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25516889"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Parveen Bhatti, Michele M Doody, Preetha Rajaraman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Radiat Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1667/RR1985.1"}], "href": "https://doi.org/10.1667/RR1985.1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20095854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20095854"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jakob Hofvander, Florian Puls, Nischalan Pillay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.5326"}], "href": "https://doi.org/10.1002/path.5326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31313299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31313299"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ming Zhao, Xiaona Yin, Huiying He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent PRDM10 Fusions in Superficial CD34-Positive Fibroblastic Tumors : A Clinicopathologic and Molecular Study of 10 Additional Cases of an Emerging Novel Entity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Clin Pathol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ajcp/aqac171"}], "href": "https://doi.org/10.1093/ajcp/aqac171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36812381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36812381"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Irma van de Beek, Iris E Glykofridis, Jan C Oosterwijk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRDM10 directs FLCN expression in a novel disorder overlapping with Birt-Hogg-Dubé syndrome and familial lipomatosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddac288"}], "href": "https://doi.org/10.1093/hmg/ddac288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36440963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36440963"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Laura S Schmidt, Cathy D Vocke, Christopher J Ricketts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRDM10 RCC: A Birt-Hogg-Dubé-like Syndrome Associated With Lipoma and Highly Penetrant, Aggressive Renal Tumors Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urology (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.urology.2023.04.035"}], "href": "https://doi.org/10.1016/j.urology.2023.04.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37331486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37331486"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Li Li, Chen Hongying, Gu Heng "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy-related LncRNA PRDM10-DT responds to UVB radiation in keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.08.013"}], "href": "https://doi.org/10.1016/j.bbrc.2023.08.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37566921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37566921"}]}]}]}
Synonyms	PFM7
Proteins	PRD10_HUMAN
NCBI Gene ID	56980
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PRDM10 has 5,252 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for PRDM10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PRDM10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PRDM10 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRDM10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRDM10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PRDM10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PRDM10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PRDM10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRDM10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PRDM10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PRDM10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PRDM10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PRDM10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRDM10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PRDM10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PRDM10 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRDM10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PRDM10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PRDM10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PRDM10 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PRDM10 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PRDM10 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PRDM10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PRDM10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PRDM10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PRDM10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PRDM10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PRDM10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PRDM10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRDM10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PRDM10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PRDM10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PRDM10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PRDM10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PRDM10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PRDM10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PRDM10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PRDM10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PRDM10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PRDM10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PRDM10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRDM10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.