PRDX5 Gene

Name	peroxiredoxin 5
Description	This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPeroxiredoxin 5 (PRDX5) is an atypical, multifunctional thioredoxin peroxidase that plays a central role in cellular antioxidant defense. It catalyzes the reduction of hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite with exceptionally high rate constants. Structural studies have revealed that PRDX5 displays a thioredoxin‐like fold and that transitioning between its reduced and oxidized forms requires marked conformational rearrangements—particularly positioning the peroxidatic and resolving cysteine residues for disulfide bond formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDue to its broad subcellular distribution—including mitochondria, peroxisomes, cytosol, and nucleus—PRDX5 is ideally positioned to protect critical cellular components from oxidative injury. In mitochondria, for example, it defends mitochondrial DNA from oxidative damage and prevents apoptosis by maintaining calcium homeostasis and membrane potential. In other cell types, such as tendon cells and thyroid follicular cells, upregulation of PRDX5 under conditions of oxidative stress confers cytoprotection by reducing apoptosis and preserving essential cellular functions such as collagen synthesis and hormone production."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond classical antioxidant protection, PRDX5 is implicated in diverse cellular processes that extend to redox‐dependent signaling and inflammation. In cancer cells, its elevated expression has been correlated with enhanced proliferation, resistance to chemotherapeutics, and activation of pro‐survival pathways. In addition, recent studies indicate that extracellular PRDX5 can interact with Toll‐like receptor 4, thereby triggering a proinflammatory response and potentially linking oxidative stress to innate immunity. PRDX5 also appears to function in the nucleus by associating with specific nuclear bodies, suggesting roles in genomic protection and transcription regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the genomic level, the regulatory mechanisms controlling PRDX5 expression are complex. Analyses of its promoter and alternative splicing variants have identified key transcription factor binding sites—including those for GABP/NRF2—that govern its constitutive and stress‐inducible expression. Such regulation appears to be critical not only for maintaining antioxidant homeostasis in a range of tissues but also in pathological conditions such as neurodegeneration, autoimmune disorders, and cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lynn Petukhova, Madeleine Duvic, Maria Hordinsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09114"}], "href": "https://doi.org/10.1038/nature09114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20596022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20596022"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J P Declercq, C Evrard, A Clippe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/jmbi.2001.4853"}], "href": "https://doi.org/10.1006/jmbi.2001.4853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11518528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11518528"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marlène Dubuisson, Delphine Vander Stricht, André Clippe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human peroxiredoxin 5 is a peroxynitrite reductase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2004.06.080"}], "href": "https://doi.org/10.1016/j.febslet.2004.06.080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15280035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15280035"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Madia Trujillo, André Clippe, Bruno Manta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2007.08.008"}], "href": "https://doi.org/10.1016/j.abb.2007.08.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17892856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17892856"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christine Evrard, Arnaud Capron, Cécile Marchand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of a dimeric oxidized form of human peroxiredoxin 5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2004.02.017"}], "href": "https://doi.org/10.1016/j.jmb.2004.02.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15046979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15046979"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ingrid Banmeyer, Cécile Marchand, André Clippe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2005.03.027"}], "href": "https://doi.org/10.1016/j.febslet.2005.03.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15848167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15848167"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jun Yuan, George A C Murrell, Annette Trickett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2004.04.006"}], "href": "https://doi.org/10.1016/j.bbamcr.2004.04.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15276323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15276323"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ingrid Banmeyer, Cécile Marchand, Catherine Verhaeghe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of human peroxiredoxin 5 in subcellular compartments of Chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2003.10.019"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2003.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14732291"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14732291"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "A-C Gérard, M-C Many, Ch Daumerie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxiredoxin 5 expression in the human thyroid gland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thyroid (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/thy.2005.15.205"}], "href": "https://doi.org/10.1089/thy.2005.15.205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15785239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15785239"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tayaba Ismail, Youni Kim, Hongchan Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20184407"}], "href": "https://doi.org/10.3390/ijms20184407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31500275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31500275"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Stéphanie De Simoni, Julie Goemaere, Bernard Knoops "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of peroxiredoxin 3 and peroxiredoxin 5 reveals the role of mitochondrial peroxiredoxins in the protection of human neuroblastoma SH-SY5Y cells toward MPP+."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2007.12.068"}], "href": "https://doi.org/10.1016/j.neulet.2007.12.068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18262354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18262354"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Geoffroy Walbrecq, Bo Wang, Sarah Becker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antioxidant cytoprotection by peroxisomal peroxiredoxin-5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2015.02.032"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2015.02.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25772011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25772011"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Andrei V Kropotov, Pavel S Grudinkin, Nadezha M Pleskach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2004.07.011"}], "href": "https://doi.org/10.1016/j.febslet.2004.07.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15304327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15304327"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Stéphanie De Simoni, Dominique Linard, Emmanuel Hermans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP+-induced cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.12117"}], "href": "https://doi.org/10.1111/jnc.12117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23216451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23216451"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Bernard Knoops, Sarah Becker, Mégane Anne Poncin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific Interactions Measured by AFM on Living Cells between Peroxiredoxin-5 and TLR4: Relevance for Mechanisms of Innate Immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Chem Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chembiol.2018.02.006"}], "href": "https://doi.org/10.1016/j.chembiol.2018.02.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29551349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29551349"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Nhu Tiên Nguyên-Nhu, Jehanne Berck, André Clippe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human peroxiredoxin 5 gene organization, initial characterization of its promoter and identification of alternative forms of mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbaexp.2007.05.004"}], "href": "https://doi.org/10.1016/j.bbaexp.2007.05.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17628720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17628720"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Andrey Kropotov, Vladimir Serikov, Jung Suh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive expression of the human peroxiredoxin V gene contributes to protection of the genome from oxidative DNA lesions and to suppression of transcription of noncoding DNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2006.05265.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2006.05265.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16817890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16817890"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "J E Holley, J Newcombe, P G Winyard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mult Scler (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1352458507078064"}], "href": "https://doi.org/10.1177/1352458507078064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17623739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17623739"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "P M Abruzzo, A Matté, A Bolotta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-019-2076-z"}], "href": "https://doi.org/10.1186/s12967-019-2076-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31578139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31578139"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Saisai Li, Xiaoli Hu, Miaomiao Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The prognostic values of the peroxiredoxins family in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20180667"}], "href": "https://doi.org/10.1042/BSR20180667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30104402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30104402"}]}]}]}
Synonyms	AOEB166, B166, PRX-V, SBBI10, PMP20, HEL-S-55, ACR1, PRXV, PRDX6
Proteins	PRDX5_HUMAN
NCBI Gene ID	25824
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PRDX5 has 9,708 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for PRDX5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PRDX5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRDX5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRDX5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PRDX5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PRDX5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRDX5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PRDX5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PRDX5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRDX5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PRDX5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PRDX5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PRDX5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRDX5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PRDX5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PRDX5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PRDX5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PRDX5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PRDX5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PRDX5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PRDX5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PRDX5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRDX5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PRDX5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PRDX5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PRDX5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PRDX5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving PRDX5 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PRDX5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PRDX5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PRDX5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PRDX5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PRDX5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PRDX5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PRDX5 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PRDX5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRDX5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PRDX5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PRDX5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PRDX5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PRDX5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PRDX5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.