{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPRKCH, the gene encoding protein kinase C‐eta (PKCη), has emerged as a key modulator of immune function and inflammatory responses. In major depressive disorder, for example, PKCη is implicated in T‐cell signaling processes that influence both disease susceptibility and responsiveness to antidepressant treatment, while in mast cells and myeloid progenitors PKCη participates in NF‐κB activation and interferon‐mediated cell cycle arrest, respectively. Moreover, altered expression of CD3 chains and related signaling components in lymphocytes from chronic lymphocytic leukemia patients further underscores its potential role in immune dysregulation. These observations highlight a multifaceted impact of PKCη on immune cell physiology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have consistently associated PRKCH variants with cerebrovascular disease. A nonsynonymous single‐nucleotide polymorphism in PRKCH is linked to an increased risk of lacunar infarction and, in some populations, lobar intracerebral hemorrhage and coronary artery disease. PKCη is expressed prominently in vascular endothelial cells and macrophages present in atherosclerotic lesions, suggesting that its altered enzymatic activity may compromise vascular integrity. Meta‐analyses further support an association between specific PRKCH alleles and increased stroke risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of oncology, PKCη exerts a dual influence on tumor cell behavior. In glioblastoma models, its activation by phorbol esters stimulates key proliferative pathways including Akt, mTOR and ERK, thereby promoting tumor growth. Similar pro‐survival and anti‐apoptotic roles are observed in Hodgkin lymphoma and breast cancer cells, where PKCη activity has been linked to resistance to chemotherapeutic agents through stabilization of anti‐apoptotic factors such as Mcl-1. Furthermore, in hepatocellular carcinoma and acute myeloid leukemia, high expression of PKCη correlates with aggressive disease and poor clinical outcome, while clear cell renal carcinomas show altered PKC isoform profiles that may include PKCη."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the cellular level, PKCη is intricately involved in diverse signaling cascades. It localizes to the Golgi, endoplasmic reticulum and nuclear envelope, an arrangement critical for its participation in vesicular trafficking and cell cycle regulation. PKCη modulates the balance between survival and apoptotic pathways—for instance, its resistance to cleavage under stress conditions enables it to suppress UV-induced or drug-induced apoptosis in keratinocytes and breast cancer cells by dampening JNK activity, while its signaling can promote senescence through upregulation of p21 and p27. In addition, PKCη phosphorylates viral proteins to facilitate replication and its own expression is tightly controlled at the level of translation via upstream open reading frames."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in intracellular signaling and tumor biology, PKCη also contributes to hemostasis and cell migration. In platelets, activation of PKCη downstream of ADP receptor signaling modulates thromboxane generation and P-selectin expression, thereby influencing platelet aggregation and inflammatory responses. Similarly, in epithelial cells, PKCη-dependent phosphorylation events regulate the activity of ion exchangers such as NHE3 at the leading edge, facilitating directional migration in response to endogenous electric fields."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "34", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies implicate PKCη in the development of non‐malignant pathologies. In diabetic nephropathy, for instance, PKC-mediated signaling—including that of PKCη—appears to couple oxidative stress and mitochondrial injury to fibrotic responses in the kidney. In the context of neurological and muscular disorders, preliminary evidence points to potential roles in multiple sclerosis and myofibrillar myopathy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "37", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M-L Wong, C Dong, J Maestre-Mesa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2008.59"}], "href": "https://doi.org/10.1038/mp.2008.59"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18504423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18504423"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ramesh P Thylur, Young-Dae Kim, Min-Sung Kwon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22307"}], "href": "https://doi.org/10.1002/jcb.22307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19693767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19693767"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Amanda J Redig, Antonella Sassano, Beata Majchrzak-Kita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of protein kinase C{eta} by type I interferons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807254200"}], "href": "https://doi.org/10.1074/jbc.M807254200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19211565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19211565"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Le Huang, Shaohua Chen, Xianfeng Zha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hematology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1179/102453312X13221316477895"}], "href": "https://doi.org/10.1179/102453312X13221316477895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22664044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22664044"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Vitor Hugo Teixeira, Laurent Jacq, Jeoiakim Moore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association and expression study of PRKCH gene in a French Caucasian population with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10875-007-9143-6"}], "href": "https://doi.org/10.1007/s10875-007-9143-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17957454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17957454"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Michiaki Kubo, Jun Hata, Toshiharu Ninomiya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1945"}], "href": "https://doi.org/10.1038/ng1945"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17206144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17206144"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lijun Wu, Yue Shen, Xin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.109.551747"}], "href": "https://doi.org/10.1161/STROKEAHA.109.551747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19520989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19520989"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hong Cheng, Feng Wang, Xinsheng Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of PRKCH gene with lacunar infarction in a local Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2009.08.046"}], "href": "https://doi.org/10.1016/j.neulet.2009.08.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19703523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19703523"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yi-Chun Chen, Phoebe Chen, Yih-Ru Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase Cη polymorphism and the susceptibilities to intracerebral hemorrhage in the Taiwan population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2012.09.023"}], "href": "https://doi.org/10.1016/j.neulet.2012.09.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22999931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22999931"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Michiaki Kubo "}, {"type": "b", "children": [{"type": "t", "text": "[Genetic risk factors of ischemic stroke identified by a genome-wide association study]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Nerve (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19069168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19069168"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lijun Wu, Bo Xi, Dongqing Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SNP (rs2230500) in PRKCH decreases the risk of carotid intima-media thickness in a Chinese young adult population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0040606"}], "href": "https://doi.org/10.1371/journal.pone.0040606"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22808203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22808203"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lingli Sun, Zhizhong Zhang, Minmin Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A quantitative assessment of the association between 1425G/A polymorphism in PRKCH and risk of stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromolecular Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12017-014-8330-x"}], "href": "https://doi.org/10.1007/s12017-014-8330-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25272991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25272991"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jiaoxing Li, Man Luo, Xiaowei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: a meta-analysis including 3686 cases and 4589 controls."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2011.10.047"}], "href": "https://doi.org/10.1016/j.neulet.2011.10.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22044875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22044875"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Lídia Ambrus, Attila Oláh, Tamás Oláh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.12660"}], "href": "https://doi.org/10.1111/jcmm.12660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26404773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26404773"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sean E Aeder, Patrick M Martin, Jae-Won Soh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208093"}], "href": "https://doi.org/10.1038/sj.onc.1208093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15489897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15489897"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "R M Uht, S Amos, P M Martin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210090"}], "href": "https://doi.org/10.1038/sj.onc.1210090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17146445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17146445"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "M Serizawa, T Nabika, Y Ochiai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between PRKCH gene polymorphisms and subcortical silent brain infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2007.11.009"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2007.11.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18164711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18164711"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Noa Rotem-Dai, Galia Oberkovitz, Sara Abu-Ghanem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKCeta confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2009.06.004"}], "href": "https://doi.org/10.1016/j.yexcr.2009.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19523467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19523467"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hsiu-Chin Lu, Fen-Pi Chou, Kun-Tu Yeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysing the expression of protein kinase C eta in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/00313020903273076"}], "href": "https://doi.org/10.3109/00313020903273076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20001341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20001341"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yasue Uchida, Saiko Sugiura, Tsutomu Nakashima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of 1425G/A polymorphism in protein kinase C-Eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurogenet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/01677063.2011.591462"}], "href": "https://doi.org/10.3109/01677063.2011.591462"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21756056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21756056"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Galit Shahaf, Noa Rotem-Dai, Gabriela Koifman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2012.01.018"}], "href": "https://doi.org/10.1016/j.yexcr.2012.01.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22305966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22305966"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Deepanwita Pal, Alakananda Basu "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase C-eta regulates Mcl-1 level via ERK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2017.09.012"}], "href": "https://doi.org/10.1016/j.cellsig.2017.09.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28939105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28939105"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Walburgis Brenner, Gloria Färber, Thomas Herget, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase C eta is associated with progression of renal cell carcinoma (RCC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14666709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14666709"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Adva Maissel, Mairav Marom, Marat Shtutman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKCeta is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation: C1b domain and the pseudosubstrate containing fragment target PKCeta to the Golgi and the nuclear envelope."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2005.09.003"}], "href": "https://doi.org/10.1016/j.cellsig.2005.09.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16242915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16242915"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Alberto M Díaz Añel "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20070359"}], "href": "https://doi.org/10.1042/BJ20070359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17492941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17492941"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Miyoko Matsumura, Naoya Tanaka, Toshio Kuroki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The eta isoform of protein kinase C inhibits UV-induced activation of caspase-3 in normal human keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00345-0"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00345-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12646210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12646210"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Nagisa Kamioka, Tomoko Akahane, Yoko Kohno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.02.125"}], "href": "https://doi.org/10.1016/j.bbrc.2010.02.125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20184865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20184865"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Hadas Raveh-Amit, Adva Maissel, Jonathan Poller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translational control of protein kinase Ceta by two upstream open reading frames."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01044-09"}], "href": "https://doi.org/10.1128/MCB.01044-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19797084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19797084"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Deepanwita Pal, Shalini Persaud Outram, Alakananda Basu "}, {"type": "b", "children": [{"type": "t", "text": "Novel regulation of protein kinase C-η."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2012.07.163"}], "href": "https://doi.org/10.1016/j.bbrc.2012.07.163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22892130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22892130"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Therese Solstad, Elisa Bjørgo, Christian J Koehler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.201000164"}], "href": "https://doi.org/10.1002/pmic.201000164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20486122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20486122"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "U Zurgil, A Ben-Ari, K Atias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PKCη promotes senescence induced by oxidative stress and chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.481"}], "href": "https://doi.org/10.1038/cddis.2014.481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25412309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25412309"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Sylvie Lachmann, Jean Rommeleare, Jürg P F Nüesch "}, {"type": "b", "children": [{"type": "t", "text": "Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.77.14.8048-8060.2003"}], "href": "https://doi.org/10.1128/jvi.77.14.8048-8060.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12829844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12829844"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Alakananda Basu, Deepanwita Pal, Rachel Blaydes "}, {"type": "b", "children": [{"type": "t", "text": "Differential effects of protein kinase C-eta on apoptosis versus senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2018.12.003"}], "href": "https://doi.org/10.1016/j.cellsig.2018.12.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30562553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30562553"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yamini S Bynagari, Bela Nagy, Florin Tuluc, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of activation and functional role of protein kinase Ceta in human platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M808970200"}], "href": "https://doi.org/10.1074/jbc.M808970200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19286657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19286657"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Danielle Libersan, Yahye Merhi "}, {"type": "b", "children": [{"type": "t", "text": "Platelet P-selectin expression: requirement for protein kinase C, but not protein tyrosine kinase or phosphoinositide 3-kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thromb Haemost (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12783114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12783114"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Nurdan Özkucur, Bing Song, Sharanya Bola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-014-1632-1"}], "href": "https://doi.org/10.1007/s00018-014-1632-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24788043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24788043"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Xiao Li, Liting Xu, Xiaoyan Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Advanced Oxidation Protein Products Aggravate Tubulointerstitial Fibrosis Through Protein Kinase C-Dependent Mitochondrial Injury in Early Diabetic Nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Antioxid Redox Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/ars.2017.7208"}], "href": "https://doi.org/10.1089/ars.2017.7208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29482336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29482336"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Rui Lin, Bruce V Taylor, Steve Simpson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Neurosurg Psychiatry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jnnp-2013-305245"}], "href": "https://doi.org/10.1136/jnnp-2013-305245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23868949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23868949"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "G Vattemi, P Tonin, M Mora, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of protein kinase C isoforms and interleukin-1beta in myofibrillar myopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/01.wnl.0000125197.70310.8e"}], "href": "https://doi.org/10.1212/01.wnl.0000125197.70310.8e"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15159477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15159477"}]}]}]}