HGNC Family | EF-hand domain containing |
Name | protein kinase C substrate 80K-H |
Description | This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPRKCSH encodes hepatocystin, a protein whose dysfunction is intimately linked to autosomal dominant polycystic liver disease (PCLD). Genetic studies have revealed that mutations in this gene disrupt its normal function in the endoplasmic reticulum, compromising its role in the processing and quality control of nascent glycoproteins. Hepatocystin, which is also known as protein kinase C substrate 80K‑H or the noncatalytic β‑subunit of glucosidase II, is predominantly localized within the ER and appears to be crucial for the proper development and maintenance of bile ducts. These findings, derived from extensive mutational analyses and expression studies in various patient cohorts, underscore a loss‑of‑function mechanism and even a potential two‑hit phenomenon contributing to cystogenesis in the liver."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n \n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in maintaining hepatic architecture, PRKCSH exerts multifaceted functions in the endoplasmic reticulum by engaging in critical protein–protein interactions. Hepatocystin functions as a chaperone‑like molecule by binding to targets such as TRPP2, thereby preventing their premature degradation, and it can modulate Ca²⁺ release through its interaction with the COOH‑terminal domain of IP3 receptors. Moreover, through its association with PKCζ and subsequent complex formation with proteins like munc18c, PRKCSH participates in the regulation of insulin‐stimulated GLUT4 vesicle trafficking. These molecular interactions highlight a conserved role for PRKCSH in ensuring proper folding, processing, and signaling of glycoproteins in diverse cellular contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n \n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its established role in hepatobiliary disease, accumulating evidence implicates PRKCSH in broader cellular processes including autophagy regulation, cell cycle control, and tumorigenesis. Hepatocystin deficiency can trigger mTOR‑dependent autophagy without perturbing unfolded protein response pathways, highlighting its role in cellular homeostasis. Aberrant expression of PRKCSH is also associated with enhanced tumor progression and altered immune cell infiltration in several cancers, and its interplay with proteins involved in Wnt/β‑catenin signaling and ciliogenesis may further widen its impact on disease pathogenesis. Moreover, emerging data suggest that dysregulation of PRKCSH may influence diabetic complications through its function as an AGE receptor, underscoring the pleiotropic nature of this protein."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joost P H Drenth, Rene H M te Morsche, Renate Smink, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Germline mutations in PRKCSH are associated with autosomal dominant polycystic liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1104"}], "href": "https://doi.org/10.1038/ng1104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12577059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12577059"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Airong Li, Sonia Davila, Laszlo Furu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/368295"}], "href": "https://doi.org/10.1086/368295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12529853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12529853"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joost P H Drenth, Jose A Martina, Rene H M Te Morsche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2004.02.023"}], "href": "https://doi.org/10.1053/j.gastro.2004.02.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15188177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15188177"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Manoe J Janssen, Esmé Waanders, René H M Te Morsche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secondary, somatic mutations might promote cyst formation in patients with autosomal dominant polycystic liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2011.08.004"}], "href": "https://doi.org/10.1053/j.gastro.2011.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21856269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21856269"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "E Waanders, H Venselaar, R H M te Morsche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secondary and tertiary structure modeling reveals effects of novel mutations in polycystic liver disease genes PRKCSH and SEC63."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1399-0004.2009.01353.x"}], "href": "https://doi.org/10.1111/j.1399-0004.2009.01353.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20095989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20095989"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Joost P H Drenth, Esa Tahvanainen, Rene H M te Morsche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.20141"}], "href": "https://doi.org/10.1002/hep.20141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15057895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15057895"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Esmé Waanders, Huib J E Croes, Cathy N Maass, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cysts of PRKCSH mutated polycystic liver disease patients lack hepatocystin but express Sec63p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-008-0381-3"}], "href": "https://doi.org/10.1007/s00418-008-0381-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18224332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18224332"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Esmé Waanders, Anke L L Lameris, Huub J M Op den Camp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatocystin is not secreted in cyst fluid of hepatocystin mutant polycystic liver patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr8000282"}], "href": "https://doi.org/10.1021/pr8000282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18419150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18419150"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "An-Ming Yang, Shou-Chuan Shih, Cheng-Hsin Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRKCSH genetic mutation was not found in Taiwanese patients with polycystic liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-009-0776-6"}], "href": "https://doi.org/10.1007/s10620-009-0776-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19308730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19308730"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wybrich R Cnossen, Jake S F Maurits, Jody Salomon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Severe Polycystic Liver Disease Is Not Caused by Large Deletions of the PRKCSH Gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.21875"}], "href": "https://doi.org/10.1002/jcla.21875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26365003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26365003"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hongyu Gao, Yan Wang, Tomasz Wegierski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp463"}], "href": "https://doi.org/10.1093/hmg/ddp463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19801576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19801576"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Conrad P Hodgkinson, Ann Mander, Graham J Sale "}, {"type": "b", "children": [{"type": "t", "text": "Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20041845"}], "href": "https://doi.org/10.1042/BJ20041845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15707389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15707389"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Katsuhiro Kawaai, Chihiro Hisatsune, Yukiko Kuroda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "80K-H interacts with inositol 1,4,5-trisphosphate (IP3) receptors and regulates IP3-induced calcium release activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M805828200"}], "href": "https://doi.org/10.1074/jbc.M805828200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18990696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18990696"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Natalie P Smithers, Conrad P Hodgkinson, Matt Cuttle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Recept Signal Transduct Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10799890802598571"}], "href": "https://doi.org/10.1080/10799890802598571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19061073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19061073"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jing Yang, Ying Zhao, Ke Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of hepatocystin induces autophagy through an mTOR-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.7.7.15822"}], "href": "https://doi.org/10.4161/auto.7.7.15822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21681021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21681021"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Edgar S Wills, René H M Te Morsche, Jeroen van Reeuwijk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx308"}], "href": "https://doi.org/10.1093/hmg/ddx308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28973524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28973524"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "A Hoverfelt, R Sallinen, J M Söderlund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DDOST, PRKCSH and LGALS3, which encode AGE-receptors 1, 2 and 3, respectively, are not associated with diabetic nephropathy in type 1 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-010-1771-3"}], "href": "https://doi.org/10.1007/s00125-010-1771-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20490454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20490454"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ridan Lei, Meiling Zhou, Shusheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential role of PRKCSH in lung cancer: bioinformatics analysis and a case study of Nano ZnO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nanoscale (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1039/d1nr08133k"}], "href": "https://doi.org/10.1039/d1nr08133k"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35254362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35254362"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Qiankun Wang, Xiong Wang, Jiaoyuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRKCSH serves as a potential immunological and prognostic biomarker in pan-cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-52153-w"}], "href": "https://doi.org/10.1038/s41598-024-52153-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38245572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38245572"}]}]}]}
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Synonyms | G19P1, AGE-R2, VASAP-60, PCLD, PKCSH, PCLD1, PLD1, GIIB |
Proteins | GLU2B_HUMAN |
NCBI Gene ID | 5589 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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PRKCSH has 8,021 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.
Click the + buttons to view associations for PRKCSH from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by PRKCSH gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PRKCSH gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of PRKCSH gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PRKCSH gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of PRKCSH gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PRKCSH gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of PRKCSH gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PRKCSH gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PRKCSH gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PRKCSH gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PRKCSH gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with PRKCSH protein from the CCLE Cell Line Proteomics dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRKCSH gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of PRKCSH gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PRKCSH gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
ClinVar Gene-Phenotype Associations | phenotypes associated with PRKCSH gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PRKCSH gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PRKCSH protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing PRKCSH protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing PRKCSH protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing PRKCSH protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with PRKCSH protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PRKCSH protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PRKCSH gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with PRKCSH gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with PRKCSH gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with PRKCSH gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of PRKCSH protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by PRKCSH gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with PRKCSH gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PRKCSH gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PRKCSH gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with PRKCSH gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with PRKCSH gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PRKCSH gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRKCSH gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of PRKCSH gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing PRKCSH from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with PRKCSH gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with PRKCSH gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of PRKCSH gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with PRKCSH gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PRKCSH from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of PRKCSH gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PRKCSH gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PRKCSH gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PRKCSH gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PRKCSH gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PRKCSH gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding PRKCSH protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving PRKCSH gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving PRKCSH gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving PRKCSH gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing PRKCSH protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing PRKCSH protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing PRKCSH protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by PRKCSH gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by PRKCSH gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by PRKCSH gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of PRKCSH gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PRKCSH gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PRKCSH gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PRKCSH gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of PRKCSH gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of PRKCSH gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for PRKCSH protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of PRKCSH gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of PRKCSH gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of PRKCSH protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PRKCSH gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HPO Gene-Disease Associations | phenotypes associated with PRKCSH gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for PRKCSH from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PRKCSH gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by PRKCSH gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for PRKCSH protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PRKCSH gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate PRKCSH protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PRKCSH gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of PRKCSH gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with PRKCSH gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PRKCSH gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of PRKCSH gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of PRKCSH gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PRKCSH gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing PRKCSH protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PRKCSH protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by PRKCSH gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting PRKCSH gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PRKCSH gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by PRKCSH gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for PRKCSH from the MSigDB Cancer Gene Co-expression Modules dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of PRKCSH gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing PRKCSH protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
OMIM Gene-Disease Associations | phenotypes associated with PRKCSH gene from the curated OMIM Gene-Disease Associations dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for PRKCSH from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PRKCSH gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of PRKCSH gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving PRKCSH protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving PRKCSH protein from the Wikipathways PFOCR 2024 dataset. | |
ProteomicsDB Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of PRKCSH protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset. | |
Reactome Pathways 2014 | pathways involving PRKCSH protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving PRKCSH protein from the Reactome Pathways 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of PRKCSH gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of PRKCSH gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of PRKCSH gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of PRKCSH gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PRKCSH gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PRKCSH gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PRKCSH gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PRKCSH gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with PRKCSH protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of PRKCSH gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PRKCSH gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PRKCSH gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of PRKCSH protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PRKCSH protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of PRKCSH protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PRKCSH protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PRKCSH protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PRKCSH protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |