PRKD3 Gene

HGNC Family	Pleckstrin homology domain containing (PLEKH)
Name	protein kinase D3
Description	This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nProtein kinase D3 (PRKD3) is emerging as a multifunctional serine/threonine kinase that orchestrates diverse cellular processes through its unique subcellular localization and activation mechanisms. In non‐polarized and polarized cells, studies have shown that PRKD3, along with its family members, localizes to the trans‐Golgi network and participates in the regulation of cargo‐selective protein transport; notably, its activity is essential in controlling the trafficking of basolateral proteins (e.g., via diacylglycerol binding and GPCR–PKC–dependent activation)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " PRKD3 displays an atypical steady‐state distribution by continuously shuttling between the cytoplasm and nucleus—a process that requires its kinase activity—and it is also capable of translocating to the plasma membrane in response to receptor activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, PRKD3 directly interacts with membrane‐associated proteins such as VAMP2 to facilitate vesicle recruitment and plasma membrane trafficking."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in trafficking, PRKD3 is a potent mediator of metabolic and proliferative signaling. In skeletal muscle cells, dominant‐negative studies indicate that PRKD3 directly contributes to insulin‐independent basal glucose uptake."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In cancer contexts, especially in triple‐negative breast cancer, elevated PRKD3 activates downstream effectors such as S6K1 via mTORC1 signaling and the ERK1/c‐MYC axis to drive cell proliferation and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, in gastric cancer cells, PRKD3 upregulates glycolytic enzyme PFKFB3 via phosphorylation of p65, thereby enhancing glycolysis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and in breast cancer its regulatory functions further extend to modulating cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " PRKD3 also influences immune-related signaling; in oral squamous cell carcinoma, its elevated expression augments PD-L1 levels by promoting STAT1/STAT3 phosphorylation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while it is essential for NF-κB-dependent transcriptional activation of latent HIV-1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPRKD3 further contributes to cell migration and invasion, key processes in cancer metastasis. Its kinase activity directly phosphorylates substrates such as GIT1 on serine 46, thereby modulating focal adhesion dynamics and cytoskeletal reorganization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Genetic rearrangements affecting PRKD3 (as well as related family members) have been identified in salivary gland malignancies, underscoring its oncogenic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " In prostate cancer, PRKD3 interacts with the molecular chaperone Hsp90 to maintain its stability, supporting tumor cell migration and metastasis, and it has been implicated in the regulation of key molecules such as prostate-specific antigen (PSA) and matrix metalloproteinase-7 (MMP-7), which are critical for tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": " In addition, dysregulated PRKD3 expression has been linked to hepatocellular carcinoma outcomes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", and emerging data indicate that PRKD3 drives malignant progression in oral squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Complementary findings also indicate that PRKD3, identified originally as PKCν in lymphocytes, functions as a critical mediator of diacylglycerol-dependent signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Charles Yeaman, M Inmaculada Ayala, Jessica R Wright, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1090"}], "href": "https://doi.org/10.1038/ncb1090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14743217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14743217"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Osvaldo Rey, Jingzhen Yuan, Steven H Young, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonists."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M300226200"}], "href": "https://doi.org/10.1074/jbc.M300226200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12676944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12676944"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Osvaldo Rey, Romeo Papazyan, Richard T Waldron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The nuclear import of protein kinase D3 requires its catalytic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M508014200"}], "href": "https://doi.org/10.1074/jbc.M508014200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16380377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16380377"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ganwei Lu, Jun Chen, Luis A Espinoza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2006.10.012"}], "href": "https://doi.org/10.1016/j.cellsig.2006.10.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17196367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17196367"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jun Chen, Ganwei Lu, Q Jane Wang "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.104.004200"}], "href": "https://doi.org/10.1124/mol.104.004200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15496505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15496505"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bettina Huck, Stephan Duss, Angelika Hausser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.502633"}], "href": "https://doi.org/10.1074/jbc.M113.502633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24337579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24337579"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yan Liu, Hang Song, Shiyi Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c-MYC axis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14772"}], "href": "https://doi.org/10.1111/jcmm.14772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31944568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31944568"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jianwei Zhang, Yajing Zhang, Jiaqi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase D3 promotes gastric cancer development through p65/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 activation of glycolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2019.04.022"}], "href": "https://doi.org/10.1016/j.yexcr.2019.04.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31026442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31026442"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yan Liu, Jian Li, Zhifang Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1938"}], "href": "https://doi.org/10.1002/cam4.1938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30652415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30652415"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bomiao Cui, Jiao Chen, Min Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2020.4974"}], "href": "https://doi.org/10.3892/ijo.2020.4974"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32319563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32319563"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Huiping Wang, Xinxing Zhu, Ying Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/968027"}], "href": "https://doi.org/10.1155/2014/968027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25136641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25136641"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Bettina Huck, Ralf Kemkemer, Mirita Franz-Wachtel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.374652"}], "href": "https://doi.org/10.1074/jbc.M112.374652"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22893698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22893698"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Salvatore Piscuoglio, Nicola Fusco, Charlotte K Y Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/his.12883"}], "href": "https://doi.org/10.1111/his.12883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26426580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26426580"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Attila Varga, Minh Tu Nguyen, Kinga Pénzes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells12020212"}], "href": "https://doi.org/10.3390/cells12020212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36672148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36672148"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Fan Deng, Chun-xia Wang, Wan-fu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[PKD3 contributes to up-regulation of prostate-specific antigen in prostate cancer cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20813663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20813663"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zhi-peng Zou, Li Feng, Wan-fu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Protein kinase D3 is involved in negative regulation of MMP-7 in prostate cancer cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20813660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20813660"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Haiyun Yang, Ming Xu, Xiufang Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Higher PKD3 expression in hepatocellular carcinoma (HCC) tissues predicts poorer prognosis for HCC patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Res Hepatol Gastroenterol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinre.2017.02.005"}], "href": "https://doi.org/10.1016/j.clinre.2017.02.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28363424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28363424"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Z Chen, Q Huang, W Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRKD3 promotes malignant progression of OSCC by downregulating KLF16 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202012_24169"}], "href": "https://doi.org/10.26355/eurrev_202012_24169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33378018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33378018"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sharon A Matthews, Rashmi Dayalu, Lucas J Thompson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of protein kinase Cnu by the B-cell antigen receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M211295200"}], "href": "https://doi.org/10.1074/jbc.M211295200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12506120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12506120"}]}]}]}
Synonyms	EPK2, PRKCN, NPKC-NU, PKC-NU, PKD3
Proteins	KPCD3_HUMAN
NCBI Gene ID	23683
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PRKD3 has 7,827 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for PRKD3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PRKD3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PRKD3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRKD3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRKD3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PRKD3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PRKD3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PRKD3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PRKD3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PRKD3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PRKD3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRKD3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PRKD3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PRKD3 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PRKD3 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRKD3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PRKD3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PRKD3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PRKD3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PRKD3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PRKD3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PRKD3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PRKD3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PRKD3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PRKD3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PRKD3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PRKD3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PRKD3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PRKD3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PRKD3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PRKD3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PRKD3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PRKD3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PRKD3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PRKD3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRKD3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PRKD3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PRKD3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PRKD3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PRKD3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PRKD3 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PRKD3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.