| Name | prion protein (testis specific) |
| Description | Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed how general transcription coactivators—notably the TAF12 and TAF4 subunits, which are shared components of the TFIID and SAGA complexes—play key roles in regulating gene expression in diverse cellular contexts. For example, targeting the TAF12/TAF4 heterodimer can disrupt oncogenic transcription factor (MYB) activity in acute myeloid leukemia, while TAF4 is also essential for proper hepatocyte maturation, epidermal integrity and pancreatic beta cell identity, in part by coordinating promoter‐proximal interactions and pre-initiation complex (PIC) formation. These works underscore the importance of intricate coactivator networks in balancing normal cell differentiation and growth, and in preventing inappropriate gene activation that can lead to tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, analysis of the human prion gene complex—which comprises PRNP, PRND, and PRNT—has focused on genetic polymorphisms that may affect disease susceptibility. Although much attention has centered on PRNP in prion pathogenesis, the specific biological function of PRNT remains less well defined. The study examining microsatellite sites across a 148‐kb region of the complex demonstrated that allele frequency differences and reduced heterozygosity (i.e. increased homozygosity) correlate with a higher risk for Creutzfeldt–Jakob Disease. These findings imply that, while direct functional studies are lacking, PRNT (by virtue of its genomic context and its shared regulatory landscape with PRNP and PRND) could be involved in modulating prion protein expression or be useful as a genetic marker for disease predisposition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yali Xu, Joseph P Milazzo, Tim D D Somerville, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2017.12.002"}], "href": "https://doi.org/10.1016/j.ccell.2017.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29316427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29316427"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniil Alpern, Diana Langer, Benoit Ballester, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.03613"}], "href": "https://doi.org/10.7554/eLife.03613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25209997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25209997"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anas Fadloun, Dominique Kobi, Jean-Christophe Pointud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.005041"}], "href": "https://doi.org/10.1242/dev.005041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17626060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17626060"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "A Fadloun, D Kobi, L Delacroix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210657"}], "href": "https://doi.org/10.1038/sj.onc.1210657"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17637747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17637747"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Igor Martianov, Emilie Cler, Isabelle Duluc, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0087365"}], "href": "https://doi.org/10.1371/journal.pone.0087365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24498316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24498316"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Thomas Kleiber, Guillaume Davidson, Gabrielle Mengus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04067-y"}], "href": "https://doi.org/10.1038/s41419-021-04067-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34385420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34385420"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hermann Geldermann, Heinz Bartenschlager, Siegfried Preuss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphic microsatellite sites in the PRNP region point to excess of homozygotes in Creutzfeldt-Jakob disease patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2006.06.012"}], "href": "https://doi.org/10.1016/j.gene.2006.06.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16889908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16889908"}]}]}]}
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| Synonyms | M8 |
| Proteins | PRNT_HUMAN |
| NCBI Gene ID | 149830 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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PRNT has 912 functional associations with biological entities spanning 7 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 31 datasets.
Click the + buttons to view associations for PRNT from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PRNT gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PRNT gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PRNT gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRNT gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of PRNT gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PRNT protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with PRNT protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PRNT gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with PRNT gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PRNT gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PRNT gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRNT gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of PRNT gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with PRNT gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of PRNT gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PRNT gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PRNT gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PRNT gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PRNT gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PRNT gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with PRNT gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with PRNT gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of PRNT gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PRNT gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PRNT gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PRNT gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PRNT gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PRNT gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PRNT gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of PRNT protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PRNT protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
