{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPROKR2 is a key G protein–coupled receptor for prokineticins that is fundamentally involved in the development of the olfactory system and the neuroendocrine reproductive axis. Pathogenic mutations in PROKR2 disrupt normal prokineticin signaling and impair olfactory bulb formation as well as the migration of gonadotropin‐releasing hormone (GnRH) neurons. Such defects underlie conditions like Kallmann syndrome and idiopathic hypogonadotropic hypogonadism, where both monoallelic and biallelic PROKR2 mutations—sometimes acting in a digenic mode—lead to variable penetrance of reproductive and olfactory deficits. Mouse models deficient in PROKR2 recapitulate these features, confirming its essential developmental role."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, PROKR2 mediates its effects by engaging multiple heterotrimeric G protein subtypes (including Gq, Gi/o, and Gs) and by recruiting β‐arrestins. Functional studies show that missense mutations in specific intracellular domains can result in “biased” signaling, defective receptor trafficking, and even dominant‐negative interactions. In addition, work on PROKR2 dimerization has revealed that interactions among transmembrane segments—particularly TM5—are critical for fine‐tuning the receptor’s signaling output and for its regulated, GRK2/clathrin‐dependent endocytosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central developmental roles, PROKR2 is expressed in several peripheral tissues where it contributes to diverse physiological processes. It is found in the endometrium, prostate, coronary endothelium, and placenta—sites in which it regulates angiogenesis, modulates cell invasiveness and vascular permeability, and can be influenced by hormonal cues such as hCG. Moreover, altered PROKR2 expression has been implicated in the inflammatory modulation of the fallopian tube and in mood disorders through its impact on circadian rhythms and pain perception. These findings underscore the multifunctional nature of PROKR2 in integrating neurodevelopment, vascular biology, and reproductive endocrinology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Catherine Dodé, Luis Teixeira, Jacqueline Levilliers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.0020175"}], "href": "https://doi.org/10.1371/journal.pgen.0020175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17054399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17054399"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lindsay W Cole, Yisrael Sidis, ChengKang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2007-2654"}], "href": "https://doi.org/10.1210/jc.2007-2654"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18559922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18559922"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ana Paula Abreu, Ericka Barbosa Trarbach, Margaret de Castro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2008-0958"}], "href": "https://doi.org/10.1210/jc.2008-0958"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18682503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18682503"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "P Canto, P Munguía, D Söderlund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis in patients with Kallmann syndrome: coexistence of mutations in prokineticin receptor 2 and KAL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Androl (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2164/jandrol.108.005314"}], "href": "https://doi.org/10.2164/jandrol.108.005314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18723471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18723471"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Carine Monnier, Catherine Dodé, Ludovic Fabre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn318"}], "href": "https://doi.org/10.1093/hmg/ddn318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18826963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18826963"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Julie Sarfati, Anne Guiochon-Mantel, Philippe Rondard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A comparative phenotypic study of kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2009-0843"}], "href": "https://doi.org/10.1210/jc.2009-0843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20022991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20022991"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Julie Sarfati, Catherine Dodé, Jacques Young "}, {"type": "b", "children": [{"type": "t", "text": "Kallmann syndrome caused by mutations in the PROK2 and PROKR2 genes: pathophysiology and genotype-phenotype correlations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Horm Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000312698"}], "href": "https://doi.org/10.1159/000312698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20389090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20389090"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Taneli Raivio, Magdalena Avbelj, Mark J McCabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2011-2938"}], "href": "https://doi.org/10.1210/jc.2011-2938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22319038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22319038"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Magdalena Avbelj Stefanija, Marc Jeanpierre, Gerasimos P Sykiotis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An ancient founder mutation in PROKR2 impairs human reproduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/dds264"}], "href": "https://doi.org/10.1093/hmg/dds264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22773735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22773735"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Antoine Moya-Plana, Carine Villanueva, Ollivier Laccourreye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PROKR2 and PROK2 mutations cause isolated congenital anosmia without gonadotropic deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Endocrinol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/EJE-12-0578"}], "href": "https://doi.org/10.1530/EJE-12-0578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23082007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23082007"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Johanna Tommiska, Jorma Toppari, Kirsi Vaaralahti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PROKR2 mutations in autosomal recessive Kallmann syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fertil Steril (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fertnstert.2012.11.003"}], "href": "https://doi.org/10.1016/j.fertnstert.2012.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23200691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23200691"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mark J McCabe, Carles Gaston-Massuet, Louise C Gregory, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2012-3067"}], "href": "https://doi.org/10.1210/jc.2012-3067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23386640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23386640"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yaguang Zhao, Jiayu Wu, Hong Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PROKR2 mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to a Gα-protein leads to biased signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201801575R"}], "href": "https://doi.org/10.1096/fj.201801575R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30576231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30576231"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Takatoshi Soga, Shun ichiro Matsumoto, Tamaki Oda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular cloning and characterization of prokineticin receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0167-4781(02)00546-8"}], "href": "https://doi.org/10.1016/s0167-4781(02"}, {"type": "t", "text": "00546-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12427552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12427552"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhen Peng, Yong Tang, Hunjin Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disease-causing mutation in PKR2 receptor reveals a critical role of positive charges in the second intracellular loop for G-protein coupling and receptor trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.223784"}], "href": "https://doi.org/10.1074/jbc.M111.223784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21454486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21454486"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ana Paula Abreu, Sekoni D Noel, Shuyun Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2012-1102"}], "href": "https://doi.org/10.1210/me.2012-1102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22745195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22745195"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wenqing Yin, Huadie Liu, Zhen Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanisms that underlie the internalization and extracellular signal regulated kinase 1/2 activation by PKR2 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2014.01.031"}], "href": "https://doi.org/10.1016/j.cellsig.2014.01.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24509228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24509228"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Oualid Sbai, Carine Monnier, Catherine Dodé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.13-243402"}], "href": "https://doi.org/10.1096/fj.13-243402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24830383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24830383"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "S Sposini, G Caltabiano, A C Hanyaloglu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of transmembrane domains that regulate spatial arrangements and activity of prokineticin receptor 2 dimers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2014.10.024"}], "href": "https://doi.org/10.1016/j.mce.2014.10.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25449422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25449422"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kimberly H Cox, Luciana M B Oliveira, Lacey Plummer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx404"}], "href": "https://doi.org/10.1093/hmg/ddx404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29161432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29161432"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "S Battersby, H O D Critchley, K Morgan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2003-032012"}], "href": "https://doi.org/10.1210/jc.2003-032012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15126578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15126578"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Daniela Pasquali, Valentina Rossi, Stefania Staibano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2006-0614"}], "href": "https://doi.org/10.1210/en.2006-0614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16763065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16763065"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromolecular Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12017-009-8067-0"}], "href": "https://doi.org/10.1007/s12017-009-8067-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19544013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19544013"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Célia Guilini, Kyoji Urayama, Gulen Turkeri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00898.2009"}], "href": "https://doi.org/10.1152/ajpheart.00898.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20023120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20023120"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Mei-Tsz Su, Sheng-Hsiang Lin, I-Wen Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/deq256"}], "href": "https://doi.org/10.1093/humrep/deq256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20847187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20847187"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Julie L V Shaw, Gillian S Wills, Kai-Fai Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2010.11.019"}], "href": "https://doi.org/10.1016/j.ajpath.2010.11.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21224062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21224062"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "S Brouillet, P Hoffmann, S Chauvet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-011-0889-x"}], "href": "https://doi.org/10.1007/s00018-011-0889-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22138749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22138749"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Anat Levit, Talia Yarnitzky, Ayana Wiener, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0027990"}], "href": "https://doi.org/10.1371/journal.pone.0027990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22132188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22132188"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Daniela Ragancokova, Elena Rocca, Anne M M Oonk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI72466"}], "href": "https://doi.org/10.1172/JCI72466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24487590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24487590"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Wael Traboulsi, Sophie Brouillet, Frederic Sergent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prokineticins in central and peripheral control of human reproduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Mol Biol Clin Investig (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hmbci-2015-0040"}], "href": "https://doi.org/10.1515/hmbci-2015-0040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26574895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26574895"}]}]}]}