PROX1 Gene

HGNC Family	Homeoboxes
Name	prospero homeobox 1
Description	The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPROX1 is a highly conserved homeobox transcription factor that plays a central role during embryogenesis by directing cell‐fate decisions. In the vascular system, PROX1 acts as a master regulator for lymphatic endothelial cell specification by inducing lymphatic markers (such as podoplanin and VEGFR3) and repressing blood endothelial characteristics, thereby re‐programming venous endothelial cells toward a lymphatic fate. PROX1 is also critical in other developmental contexts, for example in the retina where it regulates cell cycle exit and horizontal cell differentiation. These developmental functions have been demonstrated by its polarized expression in early lymphangiogenesis and diverse tissues in both chick and human embryos, underscoring its essential role in establishing and maintaining specialized cell lineages."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic and molecular evidence also implicates PROX1 in the regulation of metabolic homeostasis. Genome‐wide association studies have linked PROX1 and nearby variants with altered fasting glucose levels, defects in early insulin secretion, and type 2 diabetes susceptibility. In hepatic tissues, PROX1 modulates transcriptional programs by interacting with nuclear receptors such as LRH‐1, thereby repressing key genes like CYP7A1 that are involved in bile acid synthesis. Epigenetic mechanisms—including recruitment of repressive complexes—further refine PROX1’s role in metabolic gene regulation. Together, these findings highlight PROX1 as a critical factor for maintaining glycemic control and proper liver metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the cancer context, PROX1 exhibits complex, sometimes paradoxical roles. In colorectal cancers and other malignancies, aberrant PROX1 expression has been associated with tumor progression, enhanced invasiveness, and metastasis through modulation of cell polarity, adhesion, and epithelial–mesenchymal transition. In contrast, in some settings its loss appears to contribute to tumorigenesis, indicating a dual role as both a tumor suppressor and an oncogene depending on the tissue type. Moreover, PROX1’s involvement in inflammation‐induced lymphangiogenesis further supports its impact on tumor microenvironment remodeling and cancer dissemination. These multifaceted functions underscore the importance of context‐dependent regulation of PROX1 in tumor biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tatiana V Petrova, Taija Mäkinen, Tomi P Mäkelä, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdf470"}], "href": "https://doi.org/10.1093/emboj/cdf470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12198161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12198161"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Young-Kwon Hong, Natasha Harvey, Yun-Hee Noh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.10163"}], "href": "https://doi.org/10.1002/dvdy.10163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12412020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12412020"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "C Mouta Carreira, S M Nasser, E di Tomaso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2001)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11719431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11719431"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael A Dyer, Frederick J Livesey, Constance L Cepko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1144"}], "href": "https://doi.org/10.1038/ng1144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12692551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12692551"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sunju Lee, Jinjoo Kang, Jaehyuk Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-03-145789"}], "href": "https://doi.org/10.1182/blood-2008-03-145789"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18815287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18815287"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tomoko Yamazaki, Yasuhiro Yoshimatsu, Yasuyuki Morishita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2008.01279.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2008.01279.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19210544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19210544"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "M Rodriguez-Niedenführ, M Papoutsi, B Christ, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anat Embryol (Berl) (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00429-001-0214-9"}], "href": "https://doi.org/10.1007/s00429-001-0214-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11789987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11789987"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Josée Dupuis, Claudia Langenberg, Inga Prokopenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.520"}], "href": "https://doi.org/10.1038/ng.520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20081858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20081858"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Erik Ingelsson, Claudia Langenberg, Marie-France Hivert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db09-1568"}], "href": "https://doi.org/10.2337/db09-1568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20185807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20185807"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jun Qin, Da-Ming Gao, Quan-Feng Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2004-0009"}], "href": "https://doi.org/10.1210/me.2004-0009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15205472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15205472"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chani J Hodonsky, Deepti Jain, Ursula M Schick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006760"}], "href": "https://doi.org/10.1371/journal.pgen.1006760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28453575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28453575"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Huafang Ouyang, Yi Qin, Yanfeng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0062192"}], "href": "https://doi.org/10.1371/journal.pone.0062192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23626788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23626788"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jose C Florez, Kathleen A Jablonski, Jarred B McAteer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0044424"}], "href": "https://doi.org/10.1371/journal.pone.0044424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22984506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22984506"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sophie Lecompte, Gianni Pasquetti, Xavier Hermant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic and molecular insights into the role of PROX1 in glucose metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db12-0864"}], "href": "https://doi.org/10.2337/db12-0864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23274905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23274905"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Tatiana V Petrova, Antti Nykänen, Camilla Norrmén, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2008.02.020"}], "href": "https://doi.org/10.1016/j.ccr.2008.02.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18455124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18455124"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Michael J Flister, Andrew Wilber, Kelly L Hall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-12-196840"}], "href": "https://doi.org/10.1182/blood-2008-12-196840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19901262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19901262"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Mei-Hsuan Lu, Chao-Cheng Huang, Mei-Ren Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-12-0832"}], "href": "https://doi.org/10.1158/1078-0432.CCR-12-0832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23045246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23045246"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Masayuki Shimoda, Meiko Takahashi, Takanobu Yoshimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-06-0712"}], "href": "https://doi.org/10.1158/1078-0432.CCR-06-0712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17062673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17062673"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Nerbil Kilic, Leticia Oliveira-Ferrer, Samira Neshat-Vahid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-06-097592"}], "href": "https://doi.org/10.1182/blood-2007-06-097592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17761831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17761831"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kapo Saukkonen, Jaana Hagström, Harri Mustonen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-016-2497-5"}], "href": "https://doi.org/10.1186/s12885-016-2497-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27411302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27411302"}]}]}]}
Proteins	PROX1_HUMAN
NCBI Gene ID	5629
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PROX1 has 7,369 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for PROX1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PROX1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PROX1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PROX1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PROX1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PROX1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PROX1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PROX1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PROX1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PROX1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PROX1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PROX1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PROX1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PROX1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PROX1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PROX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PROX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PROX1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PROX1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PROX1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PROX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PROX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PROX1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PROX1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PROX1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PROX1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PROX1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PROX1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PROX1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PROX1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PROX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PROX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PROX1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PROX1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PROX1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PROX1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PROX1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PROX1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PROX1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PROX1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PROX1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PROX1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.