PRR20C Gene

Name proline rich 20C
Description This gene is one of five identical loci in a cluster on chromosome 13q21.1. The predicted protein is proline-rich and contains several dopamine D4 receptor signatures and PRINTS domains. [provided by RefSeq, Oct 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence indicates that SALM5, a neuron‐specific adhesion molecule, plays a pivotal role in maintaining central nervous system (CNS) immune privilege. One study demonstrated that SALM5 suppresses lipopolysaccharide‐induced inflammatory responses in the CNS by engaging the herpes virus entry mediator, thereby dampening excessive immune activation. Disruption of this mechanism—such as by applying a SALM‐specific monoclonal antibody—led to exacerbated inflammation and worsened clinical symptoms in experimental autoimmune encephalomyelitis models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConcurrently, an independent investigation revealed that SALM5 is essential for proper synapse formation and function. SALM5 on the postsynaptic membrane forms trans‐synaptic complexes by binding to the immunoglobulin (Ig) domains of presynaptic LAR family receptor protein tyrosine phosphatases (LAR-RPTPs). This interaction, which is strongly modulated by alternative splicing events within the LAR-RPTP Ig domains, promotes presynaptic differentiation and regulates AMPA receptor-mediated synaptic transmission. Such molecular cross-talk is critical for establishing excitatory synaptic strength and plasticity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these studies illustrate the dual functional roles of SALM5 in the CNS: it not only orchestrates synaptogenesis through trans-synaptic adhesion with LAR-RPTPs but also contributes to neuroimmune regulation by mediating anti-inflammatory responses through the herpes virus entry mediator. These insights underscore the importance of SALM5 in linking neuronal connectivity with immune homeostasis, thereby providing promising targets for the therapeutic modulation of neurological and psychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuwen Zhu, Sheng Yao, Mathew M Augustine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.1500637"}], "href": "https://doi.org/10.1126/sciadv.1500637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27152329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27152329"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yeonsoo Choi, Jungyong Nam, Daniel J Whitcomb, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep26676"}], "href": "https://doi.org/10.1038/srep26676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27225731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27225731"}]}]}]}
Synonyms PRR20B
Proteins PR20C_HUMAN
NCBI Gene ID 729240
API
Download Associations
Predicted Functions View PRR20C's ARCHS4 Predicted Functions.
Co-expressed Genes View PRR20C's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PRR20C's ARCHS4 Predicted Functions.

Functional Associations

PRR20C has 396 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for PRR20C from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of PRR20C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with PRR20C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with PRR20C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with PRR20C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PRR20C gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PRR20C gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of PRR20C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of PRR20C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of PRR20C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of PRR20C gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of PRR20C gene from the Rummagene Transcription Factor Associations 2026 dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of PRR20C gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of PRR20C gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with PRR20C protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.