PSMC5 Gene

HGNC Family	Proteasome (prosome, macropain) subunits (PSM), ATPases
Name	proteasome (prosome, macropain) 26S subunit, ATPase, 5
Description	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPSMC5, also known as SUG1, is a key AAA+ ATPase subunit of the 26S proteasome’s 19S regulatory particle that plays multifaceted roles far beyond bulk protein degradation. Early studies demonstrated that SUG1 can directly interact with nuclear receptors and transcription factors—regulating the turnover of estrogen receptors and several transcriptional coactivators—to couple proteolysis with transcriptional control. In particular, SUG1 was found to be critical for the activation of immune response genes such as those encoding MHC class II (MHC‐II) molecules, where it aids in recruitments of transactivators (e.g., CIITA) and histone modifying enzymes that sustain activating chromatin marks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these transcription‐related functions, PSMC5 has emerged as a crucial regulator of signaling complexes. Specifically, it facilitates the spatial remodeling of scaffold proteins: one study showed that PSMC5 interacts with the scaffold protein Shoc2, triggering its translocation to endosomes where it displaces the E3 ubiquitin ligase HUWE1, thereby fine‐tuning ERK1/2 signal transmission through regulation of RAF-1 ubiquitylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In addition, in radiation-responsive lung cancer cells, depletion of PSMC5 was shown to convert cells to a radioresistant state by enhancing AKT activation and augmenting MDM2-mediated degradation of p53 and p21, thus attenuating the apoptotic response to radiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, altered interactions between a NLRC4 mutant and PSMC5 have been implicated in FADD-dependent caspase-8 activation leading to apoptosis, underscoring a role for this proteasome ATPase in regulating cell death pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPSMC5 also contributes to the immunogenic properties of cells; for example, in mesenchymal stem cells, its upregulation under hypoxic conditions promotes CIITA acetylation and K63-linked ubiquitination, leading to enhanced MHC-II expression and a subsequent loss of immunoprivilege—effects that are reversed upon knocking down PSMC5."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Finally, its capacity to remodel signaling complexes by orchestrating the subcellular localization and stability of scaffold components, such as in the regulation of the Shoc2 complex, reinforces the view that PSMC5 is a multifunctional regulator operating at the interface of proteolysis, transcriptional control, and signal transduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hisashi Masuyama, Yuji Hiramatsu "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of suppressor for Gal 1 in the ubiquitin/proteasome-mediated degradation of estrogen receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312762200"}], "href": "https://doi.org/10.1074/jbc.M312762200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14702340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14702340"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Takeshi Inoue, Takahide Kon, Rieko Ajima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.02.025"}], "href": "https://doi.org/10.1016/j.bbrc.2006.02.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16499872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16499872"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kavita P Bhat, Jonathan D Turner, Sarah E Myers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The 19S proteasome ATPase Sug1 plays a critical role in regulating MHC class II transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2007.12.001"}], "href": "https://doi.org/10.1016/j.molimm.2007.12.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18215421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18215421"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Olivia I Koues, R Kyle Dudley, Agnieszka D Truax, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00535-08"}], "href": "https://doi.org/10.1128/MCB.00535-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18662994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18662994"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christine Ferry, Maurizio Gianni, Sébastien Lalevée, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M808815200"}], "href": "https://doi.org/10.1074/jbc.M808815200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19144644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19144644"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Olivia I Koues, R Kyle Dudley, Ninad T Mehta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The 19S proteasome positively regulates histone methylation at cytokine inducible genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2009.07.006"}], "href": "https://doi.org/10.1016/j.bbagrm.2009.07.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19660582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19660582"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yaritza Inostroza-Nieves, Prasanna Venkatraman, Zarixia Zavala-Ruiz "}, {"type": "b", "children": [{"type": "t", "text": "Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imlet.2012.06.005"}], "href": "https://doi.org/10.1016/j.imlet.2012.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22771340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22771340"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Eun Ryoung Jang, HyeIn Jang, Ping Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.177543"}], "href": "https://doi.org/10.1242/jcs.177543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26519477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26519477"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ji-Hye Yim, Hong Shik Yun, Su-Jae Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Radiosensitizing effect of PSMC5, a 19S proteasome ATPase, in H460 lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.11.077"}], "href": "https://doi.org/10.1016/j.bbrc.2015.11.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26592665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26592665"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Akhouri Kishore Raghawan, Anand Sripada, Gayathri Gopinath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.763979"}], "href": "https://doi.org/10.1074/jbc.M116.763979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27974463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27974463"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ejlal Abu-El-Rub, Niketa Sareen, Glen Lester Sequiera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced increase in Sug1 leads to poor post-transplantation survival of allogeneic mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202000454R"}], "href": "https://doi.org/10.1096/fj.202000454R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32770803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32770803"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Eszter Zavodszky, Sew-Yeu Peak-Chew, Szymon Juszkiewicz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a quality-control factor that monitors failures during proteasome assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.abc6500"}], "href": "https://doi.org/10.1126/science.abc6500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34446601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34446601"}]}]}]}
Synonyms	TBP10, P45/SUG, TRIP1, SUG-1, SUG1
Proteins	PRS8_HUMAN
NCBI Gene ID	5705
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PSMC5 has 8,612 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for PSMC5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PSMC5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PSMC5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSMC5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PSMC5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PSMC5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PSMC5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSMC5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PSMC5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PSMC5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PSMC5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PSMC5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PSMC5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PSMC5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PSMC5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PSMC5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PSMC5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PSMC5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PSMC5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PSMC5 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PSMC5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PSMC5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PSMC5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PSMC5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PSMC5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PSMC5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PSMC5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PSMC5 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PSMC5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PSMC5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PSMC5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PSMC5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PSMC5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PSMC5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PSMC5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PSMC5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PSMC5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PSMC5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PSMC5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PSMC5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PSMC5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PSMC5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.