PSPC1 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	paraspeckle component 1
Description	This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPSPC1 is a multifunctional RNA‐binding protein and a core component of paraspeckles, the dynamic subnuclear bodies that regulate gene expression via RNA retention and processing. PSPC1 interacts with other DBHS family members such as p54nrb and NONO to form intricately intertwined homo‐ and heterodimers that are essential for proper paraspeckle assembly and function. Its RNA recognition motifs and coiled‐coil domains are critical for these interactions and for targeting to paraspeckles, a process that depends on active RNA Polymerase II transcription."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various cancers PSPC1 is frequently upregulated and acts as a master activator of oncogenic and pro‐metastatic pathways. Elevated PSPC1 expression promotes epithelial‐to‐mesenchymal transition (EMT), cancer cell stemness and migratory signals—often through enhanced TGFβ autocrine signalling, modulation of PTK6/β‐catenin nucleocytoplasmic shuttling, and activation of IGF1R and focal adhesion pathways. Moreover, PSPC1 has been implicated in endocrine therapy resistance in ER‐positive breast cancer and its expression is associated with poor prognosis in multiple cancers, including prostate and hepatocellular carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its nuclear functions, PSPC1 plays significant roles in viral pathogenesis and epigenetic regulation. It recruits epigenetic modifiers such as TET2 to transcriptionally active genomic loci including co-opted endogenous retroviral elements, thereby influencing both transcriptional repression via histone deacetylases and post‐transcriptional RNA modification. PSPC1 also participates in the life cycles of viruses; for example, its delocalization is induced during hepatitis delta virus replication, and it can interact with specific regions of the hepatitis C virus IRES to inhibit viral RNA translation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, PSPC1 function is modulated by long non‐coding RNAs. For instance, the stress‐induced lncRNA LSINCT5—overexpressed in breast and ovarian cancers—not only enhances cellular proliferation but also affects the expression of PSPC1 among other genes, suggesting that non‐coding RNAs form part of a regulatory network involving PSPC1 in cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Archa H Fox, Charles S Bond, Angus I Lamond "}, {"type": "b", "children": [{"type": "t", "text": "P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e05-06-0587"}], "href": "https://doi.org/10.1091/mbc.e05-06-0587"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16148043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16148043"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel M Passon, Mihwa Lee, Archa H Fox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystallization of a paraspeckle protein PSPC1-NONO heterodimer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Crystallogr Sect F Struct Biol Cryst Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/S1744309111026212"}], "href": "https://doi.org/10.1107/S1744309111026212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22102035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22102035"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Daniel M Passon, Mihwa Lee, Oliver Rackham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1120792109"}], "href": "https://doi.org/10.1073/pnas.1120792109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22416126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22416126"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Andrew T Major, Yoichi Miyamoto, Camden Y Lo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep43323"}], "href": "https://doi.org/10.1038/srep43323"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28240251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28240251"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jie Huang, G Patricia Casas Garcia, Matthew A Perugini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA117.001451"}], "href": "https://doi.org/10.1074/jbc.RA117.001451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29530979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29530979"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hsi-Wen Yeh, En-Chi Hsu, Szu-Shuo Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-018-0062-y"}], "href": "https://doi.org/10.1038/s41556-018-0062-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29593326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29593326"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yaw-Dong Lang, Hsin-Yi Chen, Chun-Ming Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-13665-6"}], "href": "https://doi.org/10.1038/s41467-019-13665-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31844057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31844057"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hsin-Wei Jen, De-Leung Gu, Yaw-Dong Lang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9061490"}], "href": "https://doi.org/10.3390/cells9061490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32570949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32570949"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Carolina Cubillos-Zapata, Miguel Ángel Martínez-García, Elena Díaz-García, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Respir J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1183/13993003.00707-2022"}], "href": "https://doi.org/10.1183/13993003.00707-2022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36265878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36265878"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Toshihiko Takeiwa, Kazuhiro Ikeda, Takashi Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSPC1 is a potential prognostic marker for hormone-dependent breast cancer patients and modulates RNA processing of ESR1 and SCFD2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-13601-7"}], "href": "https://doi.org/10.1038/s41598-022-13601-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35681031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35681031"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kumaravel Mohankumar, Rupesh Shrestha, Stephen Safe "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23362"}], "href": "https://doi.org/10.1002/mc.23362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34699643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34699643"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Anna-Lena Lemster, Anika Weingart, Justus Bottner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2023.05.007"}], "href": "https://doi.org/10.1016/j.humpath.2023.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37209920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37209920"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Diana Guallar, Xianju Bi, Jose Angel Pardavila, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41588-018-0060-9"}], "href": "https://doi.org/10.1038/s41588-018-0060-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29483655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29483655"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yasnee Beeharry, Gabrielle Goodrum, Christian J Imperiale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-24500-1"}], "href": "https://doi.org/10.1038/s41598-018-24500-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29662142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29662142"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sachin Kumar Tripathi, Ashish Aneja, Teji Borgaonkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSPC1 Binds to HCV IRES and Prevents Ribosomal Protein S5 Binding, Inhibiting Viral RNA Translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Viruses (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/v16050738"}], "href": "https://doi.org/10.3390/v16050738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38793620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38793620"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jessica M Silva, Nicole J Boczek, Michael W Berres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/rna.8.3.14800"}], "href": "https://doi.org/10.4161/rna.8.3.14800"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21532345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21532345"}]}]}]}
Synonyms	PSP1
Proteins	PSPC1_HUMAN
NCBI Gene ID	55269
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PSPC1 has 7,866 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for PSPC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PSPC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSPC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSPC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PSPC1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PSPC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PSPC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PSPC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PSPC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PSPC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PSPC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PSPC1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PSPC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PSPC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PSPC1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PSPC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PSPC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PSPC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PSPC1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PSPC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PSPC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PSPC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PSPC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PSPC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PSPC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PSPC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PSPC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PSPC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PSPC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PSPC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PSPC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PSPC1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PSPC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PSPC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PSPC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PSPC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PSPC1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PSPC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PSPC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PSPC1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PSPC1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PSPC1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.