{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent genome‐wide association studies have consistently implicated PSRC1—a gene located within the 1p13 locus alongside CELSR2 and SORT1—as an important regulator of lipid metabolism. In these studies, common variants (notably rs599839) were robustly associated with variations in serum lipid levels, particularly low‐density lipoprotein cholesterol (LDL‐C) and total cholesterol, thereby influencing coronary artery disease risk. These findings, observed in large multi‐cohort analyses, support a model in which PSRC1‐related loci contribute substantially to heritable differences in lipoprotein profiles and atherosclerotic risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementary investigations in diverse ethnic populations have further confirmed the role of PSRC1 polymorphisms in modulating cholesterol levels and coronary risk. In these studies, the minor allele of rs599839 and other related single nucleotide polymorphisms have been correlated with either a protective effect or lower cholesterol concentrations, findings that have been replicated in South Asian, Mexican, and Chinese cohorts. This collective evidence underscores the importance of PSRC1 in lipid regulation, positioning it as a promising biomarker for cardiovascular risk stratification and as a potential target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chris Wallace, Stephen J Newhouse, Peter Braund, et al. 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