| Name | protein phosphatase 2 phosphatase activator |
| Description | Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPTPA is an essential cellular regulator that activates protein phosphatase 2A (PP2A) by promoting a conformational change in its catalytic subunit. Its peptidyl‐prolyl cis/trans‐isomerase activity facilitates the proper folding and metal ion binding required for PP2A to achieve its pSer/Thr-specific phosphatase activity. In addition, PTPA is incorporated into a broader network of PP2A modulators that help prevent premature or promiscuous phosphatase activity until the full holoenzyme is properly assembled, thereby contributing to controlled cell proliferation and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural studies of PTPA reveal that it possesses a unique all α-helical fold organized into distinct subdomains (core, lid, and linker). A highly conserved surface patch mediates binding to PP2A, while a deep pocket accommodates ATP, enabling PTPA to participate in a composite ATPase activity when complexed with PP2A. This arrangement not only stabilizes the proper protein fold of the PP2A catalytic subunit but also positions ATP phosphoryl groups to modulate metal binding and ultimately alter the substrate specificity of PP2A. Mutations that impair PTPA’s cis/trans-isomerase or ATPase functions disrupt PP2A reactivation, underscoring its critical regulatory role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jan Jordens, Veerle Janssens, Sari Longin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M507760200"}], "href": "https://doi.org/10.1074/jbc.M507760200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16380387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16380387"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ward Sents, Elitsa Ivanova, Caroline Lambrecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2012.08579.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2012.08579.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22443683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22443683"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yang Chao, Yongna Xing, Yu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and mechanism of the phosphotyrosyl phosphatase activator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.07.027"}], "href": "https://doi.org/10.1016/j.molcel.2006.07.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16916641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16916641"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Feng Guo, Vitali Stanevich, Nathan Wlodarchak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2013.138"}], "href": "https://doi.org/10.1038/cr.2013.138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24100351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24100351"}]}]}]}
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| NCBI Gene ID | 5524 |
| API | |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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PTPA has 1,481 functional associations with biological entities spanning 5 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 24 datasets.
Click the + buttons to view associations for PTPA from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PTPA gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with PTPA protein from the CCLE Cell Line Proteomics dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PTPA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of PTPA gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| DGIdb Drug Targets 2026 | interacting drugs for PTPA protein from the DGIdb Drug Targets 2026 dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving PTPA gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with PTPA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PTPA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with PTPA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with PTPA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving PTPA gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing PTPA protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by PTPA gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PTPA gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of PTPA gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of PTPA gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of PTPA gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of PTPA gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving PTPA protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving PTPA protein from the Wikipathways PFOCR 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of PTPA gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PTPA gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PTPA gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| WikiPathways Pathways 2024 | pathways involving PTPA protein from the WikiPathways Pathways 2024 dataset. | |
