PTPN9 Gene

HGNC Family	Phosphatases
Name	protein tyrosine phosphatase, non-receptor type 9
Description	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPTPN9, also known as PTP‐MEG2, plays a central role in intracellular membrane dynamics by regulating vesicle fusion. Its catalytic activity enables the dephosphorylation of key fusion mediators such as NSF, thereby promoting homotypic fusion of secretory vesicles. In addition, the enzyme’s N‐terminal Sec14p homology domain binds phosphoinositides to direct its membrane targeting, effectively coupling inositide signaling to dephosphorylation events. Recent findings further extend its function to autophagy, where PTPN9 dephosphorylates components like the Q‐SNARE VTI1B to facilitate the homotypic fusion of ATG16L1‐positive autophagosome precursors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in vesicular trafficking, PTPN9 acts as a critical regulator of multiple signaling pathways. By dephosphorylating receptor tyrosine kinases such as ErbB2, EGFR, and VEGFR2, it suppresses downstream cascades including STAT activation and IL‐6 production. Such modulation not only tempers proliferative and inflammatory responses but also impacts insulin signaling by antagonizing receptor phosphorylation, thereby influencing metabolic homeostasis. Moreover, in vascular and neural cells, PTPN9 helps regulate cytokine production and cellular responses to inflammatory stimuli."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPTPN9 has also emerged as a tumor suppressor in several human cancers. In breast, liver, colorectal, and lung malignancies, reduced expression or aberrant regulation of PTPN9 is associated with enhanced receptor tyrosine kinase signaling, increased cellular proliferation, and diminished apoptosis. For instance, in breast cancer, miRNAs such as miR‐96 directly target and silence PTPN9, whereas in colorectal cancer miR‐21 suppresses its expression, both of which promote tumor progression. Altered PTPN9 expression has additionally been linked to clinical parameters such as tumor size, proliferation indices, and overall prognosis. Genetic studies further suggest that polymorphisms in the PTPN9 gene may contribute to susceptibility in conditions like alcohol‐induced osteonecrosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Qi, Runxiang Zhao, Hongxi Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Purification and characterization of protein tyrosine phosphatase PTP-MEG2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.10195"}], "href": "https://doi.org/10.1002/jcb.10195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12112018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12112018"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ming-Jiang Xu, Xingwei Sui, Runxiang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-04-1308"}], "href": "https://doi.org/10.1182/blood-2003-04-1308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12920026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12920026"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Huong Huynh, Xiaodong Wang, Weizhong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.171.12.6661"}], "href": "https://doi.org/10.4049/jimmunol.171.12.6661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14662869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14662869"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Huong Huynh, Nunzio Bottini, Scott Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of vesicle fusion by a tyrosine phosphatase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1164"}], "href": "https://doi.org/10.1038/ncb1164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15322554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15322554"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kan Saito, Scott Williams, Anna Bulankina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of protein-tyrosine phosphatase MEG2 via its Sec14p homology domain with vesicle-trafficking proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M608682200"}], "href": "https://doi.org/10.1074/jbc.M608682200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17387180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17387180"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "He-Yen Chou, Yi-Tang Lee, Yuchieh Jay Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2020.1838117"}], "href": "https://doi.org/10.1080/15548627.2020.1838117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33112705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33112705"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Charles Y Cho, Seung-Hoi Koo, Yan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2006.03.006"}], "href": "https://doi.org/10.1016/j.cmet.2006.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16679294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16679294"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Taichang Yuan, Yongping Wang, Zhizhuang J Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.099879"}], "href": "https://doi.org/10.1074/jbc.M109.099879"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20335174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20335174"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Fuqin Su, Fangli Ren, Yu Rong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr3134"}], "href": "https://doi.org/10.1186/bcr3134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22394684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22394684"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Qin Hao, Buka Samten, Hong-Long Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00415.2011"}], "href": "https://doi.org/10.1152/ajpcell.00415.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22763125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22763125"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "E M Desouky, A K Khaliefa, W G Hozayen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signature of miR-21 and MEG-2 and their correlation with TGF-β signaling in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Exp Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/09603271231159799"}], "href": "https://doi.org/10.1177/09603271231159799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36825546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36825546"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Baoying Hu, Xia Yan, Fang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulated Expression of PTPN9 Contributes to Human Hepatocellular Carcinoma Growth and Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12253-015-0038-1"}], "href": "https://doi.org/10.1007/s12253-015-0038-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26715439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26715439"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yeting Hong, Hongwei Liang, Uzair-Ur-Rehman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep37421"}], "href": "https://doi.org/10.1038/srep37421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27857177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27857177"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhijian Liu, Feng Sun, Yeting Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-017-0695-7"}], "href": "https://doi.org/10.1186/s12943-017-0695-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28747184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28747184"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dongjian Ying, Yi Ruan, Xinhua Zhou "}, {"type": "b", "children": [{"type": "t", "text": "MEG2 inhibits the growth and metastasis of hepatocellular carcinoma by inhibiting AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.11.003"}], "href": "https://doi.org/10.1016/j.gene.2018.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30399427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30399427"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zengtao Bao, Shanting Gao, Baoming Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Critical Role of the miR-21-MEG2 Axis in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2020036484"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2020036484"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33463918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33463918"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jun Xiong, Yi Niu, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of L3MBTL3/PTPN9 polymorphisms on risk to alcohol-induced ONFH in Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10072-021-05486-7"}], "href": "https://doi.org/10.1007/s10072-021-05486-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34373992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34373992"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Lihuan Zhu, Tianxing Guo, Wenshu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircMMD_007 promotes oncogenic effects in the progression of lung adenocarcinoma through microRNA-197-3p/protein tyrosine phosphatase non-receptor type 9 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2037956"}], "href": "https://doi.org/10.1080/21655979.2022.2037956"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35156900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35156900"}]}]}]}
Synonyms	MEG2, PTPMEG2
Proteins	PTN9_HUMAN
NCBI Gene ID	5780
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PTPN9 has 6,517 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for PTPN9 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PTPN9 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPN9 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPN9 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PTPN9 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PTPN9 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PTPN9 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPN9 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PTPN9 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PTPN9 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PTPN9 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PTPN9 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PTPN9 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PTPN9 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PTPN9 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PTPN9 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PTPN9 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PTPN9 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PTPN9 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PTPN9 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PTPN9 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PTPN9 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PTPN9 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PTPN9 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PTPN9 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PTPN9 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PTPN9 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PTPN9 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PTPN9 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PTPN9 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PTPN9 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PTPN9 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PTPN9 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PTPN9 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PTPN9 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PTPN9 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PTPN9 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PTPN9 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PTPN9 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PTPN9 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PTPN9 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PTPN9 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.