PTPRB Gene

HGNC Family	Phosphatases, Fibronectin type III domain containing
Name	protein tyrosine phosphatase, receptor type, B
Description	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPTPRB, also known as vascular endothelial‐protein tyrosine phosphatase (VE‐PTP), is an endothelial cell–specific receptor that functions as a key negative regulator of receptor tyrosine kinase signaling. It modulates angiogenesis and vascular development by dephosphorylating targets such as vascular growth factor receptors and Tie2. In malignant vascular tumors such as angiosarcomas, recurrent truncating mutations in PTPRB underscore its role in aberrant angiogenesis, while biochemical studies have demonstrated that physiological inhibitors such as zinc(II) ions potently and reversibly inhibit PTPRB activity, suggesting a role for zinc in fine‐tuning vascular signaling processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPTPRB is also central to the regulation of endothelial cell behavior and vascular integrity. Through its dephosphorylation of key receptors—including VEGFR2, Tie2, and the adherens junction protein VE‐cadherin—it governs processes ranging from tube formation and cell spreading to the dynamic reorganization of junctional complexes in response to shear stress. Studies have shown that silencing or inhibition of PTPRB results in enhanced receptor phosphorylation, altered cell morphology, and disturbed junctional assembly, while its polarized redistribution under flow conditions ensures proper endothelial alignment and barrier function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its fundamental roles in vascular biology, perturbations of PTPRB expression and function have been associated with various pathologies. In non‐small cell lung cancer models, reduced PTPRB expression correlates with increased Src phosphorylation, enhanced cellular invasion, and tumor progression, suggesting a tumor‐suppressive facet. Likewise, genetic variants in PTPRB have been linked to congenital heart defects such as hypoplastic left heart syndrome, as well as to predisposition for conditions like Graves’ disease and substance abuse vulnerability. These observations highlight not only the diverse physiological roles of PTPRB but also its potential as a biomarker and therapeutic target in multiple diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Matthew Wilson, Christer Hogstrand, Wolfgang Maret "}, {"type": "b", "children": [{"type": "t", "text": "Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase β activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C111.320796"}], "href": "https://doi.org/10.1074/jbc.C111.320796"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22275360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22275360"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sam Behjati, Patrick S Tarpey, Helen Sheldon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent PTPRB and PLCG1 mutations in angiosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2921"}], "href": "https://doi.org/10.1038/ng.2921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24633157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24633157"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Unknown Authors "}, {"type": "b", "children": [{"type": "t", "text": "Angiogenesis-related gene mutations drive a subset of angiosarcomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-RW2014-069"}], "href": "https://doi.org/10.1158/2159-8290.CD-RW2014-069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24795022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24795022"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Orisha K Yacyshyn, Patrick F H Lai, Kelly Forse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Angiogenesis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10456-008-9126-0"}], "href": "https://doi.org/10.1007/s10456-008-9126-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19116766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19116766"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sofie Mellberg, Anna Dimberg, Fuad Bahram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-123810"}], "href": "https://doi.org/10.1096/fj.08-123810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19136612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19136612"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Munemasa Mori, Yoji Murata, Takenori Kotani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.22122"}], "href": "https://doi.org/10.1002/jcp.22122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20301196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20301196"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kemala Isnainiasih Mantilidewi, Yoji Murata, Munemasa Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.529503"}], "href": "https://doi.org/10.1074/jbc.M113.529503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24451369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24451369"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dheeraj Soni, Sushil C Regmi, Dong-Mei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " entry regulates disassembly of adherens junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00008.2017"}], "href": "https://doi.org/10.1152/ajplung.00008.2017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28385807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28385807"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ana-Maria Rosca, Daniel Nicolae Mitroi, Valeriu Cismasiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR-377/VE-PTP axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13712"}], "href": "https://doi.org/10.1111/jcmm.13712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30044046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30044046"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hiroki Ishiguro, Jian-Ping Gong, F Scott Hall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of PTPRB gene polymorphism with drug addiction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30742"}], "href": "https://doi.org/10.1002/ajmg.b.30742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18361428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18361428"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xingyue Weng, Wei Chen, Wangxiong Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1554-9"}], "href": "https://doi.org/10.1038/s41419-019-1554-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31040266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31040266"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yangying Jia, Jianhai Chen, Jie Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel rare mutation in a conserved site of PTPRB causes human hypoplastic left heart syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.14234"}], "href": "https://doi.org/10.1111/cge.14234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36148623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36148623"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Wei Li, Haidong Jiang, Xu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000031501"}], "href": "https://doi.org/10.1097/MD.0000000000031501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36397361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36397361"}]}]}]}
Synonyms	HPTP-BETA, PTPB, VEPTP, HPTPB, R-PTP-BETA
Proteins	PTPRB_HUMAN
NCBI Gene ID	5787
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PTPRB has 6,192 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for PTPRB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PTPRB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPRB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPRB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PTPRB gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PTPRB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PTPRB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPRB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving PTPRB protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PTPRB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PTPRB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PTPRB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PTPRB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PTPRB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PTPRB protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PTPRB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PTPRB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PTPRB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PTPRB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PTPRB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PTPRB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PTPRB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PTPRB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PTPRB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PTPRB protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PTPRB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PTPRB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with PTPRB gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PTPRB gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PTPRB protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PTPRB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PTPRB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PTPRB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PTPRB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PTPRB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PTPRB protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PTPRB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PTPRB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PTPRB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PTPRB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PTPRB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PTPRB gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.