PTPRC Gene

HGNC Family	Fibronectin type III domain containing, Phosphatases, CD molecules (CD)
Name	protein tyrosine phosphatase, receptor type, C
Description	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPTPRC, which encodes the CD45 protein, is a critical, evolutionarily conserved receptor‐type protein tyrosine phosphatase expressed on all nucleated hematopoietic cells. It plays a central role in initiating and modulating antigen receptor signaling by dephosphorylating key substrates—including the Src‐family kinases Lck and Fyn—to set activation thresholds in T cells. Its biochemical activity establishes a “gatekeeper” function at the immunological synapse by balancing kinase and phosphatase signals, and its proper conformation and dimerization (with structurally distinct D1 and D2 domains) are essential for ensuring rapid, regulated responses during lymphocyte activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "In addition to its well‐established role in T cell receptor signaling, CD45 influences diverse cytokine and adhesion receptor pathways. Its phosphatase activity negatively regulates signaling by JAK family kinases downstream of cytokine receptors (for example, modulating IL-6 and IL-4 responses), and it governs chemotactic responses—such as those mediated by CXCR4—to affect cellular migration. Moreover, alterations in CD45 expression or activity (including via modulation of its glycosylation state and interactions with galectins) impact disease processes, ranging from hematologic malignancies (where CD45 loss‐of‐function mutations can promote oncogenic signaling) to the modulation of inhibitory receptors like SLAMF7, and may even influence the cellular susceptibility to bacterial toxins."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "17"}]}, {"type": "t", "text": "Beyond its immediate signaling roles, CD45 is subject to extensive regulation at the transcriptional and post‐transcriptional levels. Alternative splicing of its variable exons produces distinct isoforms that characterize different lymphocyte subsets and activation states—such as naïve versus memory or regulatory T cells—and these isoforms help define immune cell identity and function. Moreover, interactions with the cytoskeleton (involving proteins like spectrin and ankyrin) further influence the spatial distribution and activity of CD45 at membrane microdomains, thereby fine-tuning downstream signaling events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "22"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Deepti Pradhan, Jon Morrow "}, {"type": "b", "children": [{"type": "t", "text": "The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1074-7613(02)00396-5"}], "href": "https://doi.org/10.1016/s1074-7613(02"}, {"type": "t", "text": "00396-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12354383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12354383"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christophe Blanchetot, Leon G Tertoolen, John Overvoorde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205810200"}], "href": "https://doi.org/10.1074/jbc.M205810200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12376545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12376545"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hyun-Joo Nam, Florence Poy, Haruo Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20041890"}], "href": "https://doi.org/10.1084/jem.20041890"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15684325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15684325"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alan Tong, Jason Nguyen, Kristen W Lynch "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of CD45 isoforms is controlled by the combined activity of basal and inducible splicing-regulatory elements in each of the variable exons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M508123200"}], "href": "https://doi.org/10.1074/jbc.M508123200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16172127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16172127"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Michaël Porcu, Maria Kleppe, Valentina Gianfelici, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-09-379958"}], "href": "https://doi.org/10.1182/blood-2011-09-379958"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22438252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22438252"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Andreas Rheinländer, Burkhart Schraven, Ursula Bommhardt "}, {"type": "b", "children": [{"type": "t", "text": "CD45 in human physiology and clinical medicine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imlet.2018.01.009"}], "href": "https://doi.org/10.1016/j.imlet.2018.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29366662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29366662"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Adam H Courtney, Alexey A Shvets, Wen Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD45 functions as a signaling gatekeeper in T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aaw8151"}], "href": "https://doi.org/10.1126/scisignal.aaw8151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31641081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31641081"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hideaki Ishikawa, Naohiro Tsuyama, Saeid Abroun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v99.6.2172"}], "href": "https://doi.org/10.1182/blood.v99.6.2172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11877294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11877294"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Cheng Zhou, Andrew Saxon, Ke Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.170.4.1887"}], "href": "https://doi.org/10.4049/jimmunol.170.4.1887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12574355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12574355"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "A Vogel, C P Strassburg, M P Manns "}, {"type": "b", "children": [{"type": "t", "text": "77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.gene.6363918"}], "href": "https://doi.org/10.1038/sj.gene.6363918"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12595907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12595907"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mai Zhang, Ajit Varki "}, {"type": "b", "children": [{"type": "t", "text": "Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycobiology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/glycob/cwh126"}], "href": "https://doi.org/10.1093/glycob/cwh126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15240561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15240561"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jennifer A Fulcher, Margaret H Chang, Shuo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.037507"}], "href": "https://doi.org/10.1074/jbc.M109.037507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19635795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19635795"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fernando Ruiz-Perez, Rezwanul Wahid, Christina S Faherty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1101006108"}], "href": "https://doi.org/10.1073/pnas.1101006108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21768350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21768350"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Mary C Clark, Mabel Pang, Daniel K Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-06-438234"}], "href": "https://doi.org/10.1182/blood-2012-06-438234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23065155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23065155"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Huaijian Guo, Mario-Ernesto Cruz-Munoz, Ning Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01107-14"}], "href": "https://doi.org/10.1128/MCB.01107-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25312647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25312647"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Angelino T Tromp, Michiel Van Gent, Pauline Abrial, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Microbiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41564-018-0159-x"}], "href": "https://doi.org/10.1038/s41564-018-0159-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29736038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29736038"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ricardo A Fernandes, Leon Su, Yoko Nishiga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immune receptor inhibition through enforced phosphatase recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-020-2851-2"}], "href": "https://doi.org/10.1038/s41586-020-2851-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33087934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33087934"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Nabila Seddiki, Brigitte Santner-Nanan, Stuart G Tangye, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Different proliferative potential and migratory characteristics of human CD4+ regulatory T cells that express either CD45RA or CD45RO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903781"}], "href": "https://doi.org/10.4049/jimmunol.0903781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20231690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20231690"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ni-Ting Chiou, Ganesh Shankarling, Kristen W Lynch "}, {"type": "b", "children": [{"type": "t", "text": "hnRNP L and hnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.12.025"}], "href": "https://doi.org/10.1016/j.molcel.2012.12.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23394998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23394998"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yuan Tian, Mariana Babor, Jerome Lane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-01728-5"}], "href": "https://doi.org/10.1038/s41467-017-01728-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29133794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29133794"}]}]}]}
Synonyms	CD45, CD45R, LY5, T200, L-CA, B220
Proteins	PTPRC_HUMAN
NCBI Gene ID	5788
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PTPRC has 14,399 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 136 datasets.

Click the + buttons to view associations for PTPRC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PTPRC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PTPRC gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPRC gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPRC gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PTPRC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PTPRC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PTPRC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PTPRC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving PTPRC protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PTPRC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PTPRC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PTPRC gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PTPRC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PTPRC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PTPRC gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PTPRC protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PTPRC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PTPRC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PTPRC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PTPRC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with PTPRC gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PTPRC gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PTPRC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PTPRC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PTPRC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PTPRC protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PTPRC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PTPRC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PTPRC gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PTPRC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PTPRC gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PTPRC gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving PTPRC gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving PTPRC gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PTPRC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PTPRC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PTPRC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PTPRC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PTPRC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PTPRC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PTPRC gene from the ENCODE Histone Modification Site Profiles dataset.